1. Cell Cycle/DNA Damage
    PROTAC
  2. CDK
    PROTAC
  3. CDK9 Antagonist-1

CDK9 Antagonist-1 

Cat. No.: HY-112811
Handling Instructions

CDK9 Antagonist-1 (compounds 11c) is a potent and selective CDK9 degrader based on PROTAC, with an IC50 of 17 μM in MCF-7 cell lines. Natural product Wogonin binds ubiquitin E3 ligase cereblon (CRBN) via a linker to form PROTAC.

For research use only. We do not sell to patients.

CDK9 Antagonist-1 Chemical Structure

CDK9 Antagonist-1 Chemical Structure

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Description

CDK9 Antagonist-1 (compounds 11c) is a potent and selective CDK9 degrader based on PROTAC, with an IC50 of 17 μM in MCF-7 cell lines. Natural product Wogonin binds ubiquitin E3 ligase cereblon (CRBN) via a linker to form PROTAC[1].

IC50 & Target[1]

CDK9

17 μM (IC50, MCF-7 cells)

Molecular Weight

748.74

Formula

C₃₉H₃₆N₆O₁₀

SMILES

O=C(C=C(C1=CC=CC=C1)O2)C3=C2C(OCC4=CN(CCCCCCCC(NC5=C(C(N(C6C(NC(CC6)=O)=O)C7=O)=O)C7=CC=C5)=O)N=N4)=C(O)C=C3O

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Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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CDK9 Antagonist-1
Cat. No.:
HY-112811
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