2435721-30-3
Chemical Structure
PROTAC CDK9 degrader-2
- CAS No.: 2435721-30-3
- Formula:C39H36N6O10
- Molecular Weight:748.74
IUPAC Name: 8-(4-(((5,7-dihydroxy-4-oxo-2-phenyl-4H-chromen-8-yl)oxy)methyl)-1H-1,2,3-triazol-1-yl)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)octanamide
InChIKey: MRRHEHIWXXJQQL-UHFFFAOYSA-N
SMILES: O=C(C=C(C1=CC=CC=C1)O2)C3=C2C(OCC4=CN(CCCCCCCC(NC5=C(C(N(C6C(NC(CC6)=O)=O)C7=O)=O)C7=CC=C5)=O)N=N4)=C(O)C=C3O
Biological Activity: PROTAC CDK9 degrader-2 is a PROTAC degrader targeting CDK9, with an IC50 of 523 nM. PROTAC CDK9 degrader-2 selectively degrades CDK9 via the cereblon-dependent ubiquitin-proteasome pathway and inhibits the proliferation of cancer cells overexpressing CDK9. PROTAC CDK9 degrader-2 can be used for cancer research[1].
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PROTAC CDK9 degrader-2 | 99.22% | PROTAC CDK9 degrader-2 is a PROTAC degrader targeting CDK9, with an IC50 of 523 nM. PROTAC CDK9 degrader-2 selectively degrades CDK9 via the cereblon-dependent ubiquitin-proteasome pathway and inhibits the proliferation of cancer cells overexpressing CDK9. PROTAC CDK9 degrader-2 can be used for cancer research. | ||||||||||||||||||||
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