PROTAC CDK9 degrader-6
Based on 1 publication(s) in Google Scholar
PROTAC CDK9 degrader-6 is a PROTAC targeting to CDK9 sepcifically. PROTAC CDK9 degrader-6 mediates CDK9 degradation via the proteasome. PROTAC CDK9 degrader-6 degrades CDK9 with DC50s of 0.10 μM and 0.14 μM for the CDK942 and CDK955 isoforms, respectively.
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- CAS. Nr.: 2935587-91-8
- Formel: C42H49Cl2N9O8
- Molecular Weight:878.80
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Publications Citing Use of MedChemExpress (MCE) PROTAC CDK9 degrader-6
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Biologische Aktivität
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CDK942 0.03 μM (DC50) |
CDK955 0.05 μM (DC50) |
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Cell Line
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Type | Value | Description | References |
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| MOLM-13 | IC50 |
42.08 μM
Compound: 16
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Anticancer activity against human MOLM-13 cells assessed as cell growth inhibition measured after 48 hrs by MTS assay
Anticancer activity against human MOLM-13 cells assessed as cell growth inhibition measured after 48 hrs by MTS assay
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[PMID: 37071962] |
| MV4-11 | EC50 |
0.2 μM
Compound: 16
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Anticancer activity against human MV4-11 cells assessed as cell growth inhibition for 6 hrs followed by compound washout measured after 24 hrs by Annexin V/Propidium iodide staining based flow cytometric analysis
Anticancer activity against human MV4-11 cells assessed as cell growth inhibition for 6 hrs followed by compound washout measured after 24 hrs by Annexin V/Propidium iodide staining based flow cytometric analysis
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[PMID: 37071962] |
PROTAC CDK9 degrader-6 (compound 16) (1 μM; 6 h) decreases the protein level of MCL2, and competely degrades CDK9 in MV411 cells[1].
PROTAC CDK9 degrader-6 (1 μM; 1-6 h) time-dependently decreases the protein level of MCL2, and CDK9, and remaines suppression for 24 h[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MV411 cells
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Concentration:1 μM
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Incubation Time:1 h, 2 h, 4 h, 6 h
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Result:Degraded CDK9 starting at 2 h incubation and reaching a plateau at 4 h.
Remained suppressed for 24 h with some recurrence at 48 h after finished treatment.
Chemical Information
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CAS. Nr. 2935587-91-8
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Molecular Weight 878.80
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Formel C42H49Cl2N9O8
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SMILES
O=C(NCCCCCCCCCCC(N1CCC(CC1)NC(C2=NNC=C2NC(C3=C(C=CC=C3Cl)Cl)=O)=O)=O)CNC4=CC=CC(C(N5C6CCC(NC6=O)=O)=O)=C4C5=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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J Med Chem
Identification of a Potent and Selective CDK9 Degrader as a Targeted Therapeutic Option for the Treatment of Small-Cell Lung Cancer. [Abstract]2025 Feb 13;68(3):2528-2550. PMID: 39895086
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Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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