2935587-91-8
Chemical Structure
PROTAC CDK9 degrader-6
- CAS No.: 2935587-91-8
- Formula:C42H49Cl2N9O8
- Molecular Weight:878.80
IUPAC Name: 4-(2,6-dichlorobenzamido)-N-(1-(11-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)acetamido)undecanoyl)piperidin-4-yl)-1H-pyrazole-3-carboxamide
InChIKey: SRUVBNFPTDBESG-UHFFFAOYSA-N
SMILES: O=C(NCCCCCCCCCCC(N1CCC(CC1)NC(C2=NNC=C2NC(C3=C(C=CC=C3Cl)Cl)=O)=O)=O)CNC4=CC=CC(C(N5C6CCC(NC6=O)=O)=O)=C4C5=O
Biological Activity: PROTAC CDK9 degrader-6 is a PROTAC targeting to CDK9 sepcifically. PROTAC CDK9 degrader-6 mediates CDK9 degradation via the proteasome. PROTAC CDK9 degrader-6 degrades CDK9 with DC50s of 0.10 μM and 0.14 μM for the CDK942 and CDK955 isoforms, respectively[1].
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PROTAC CDK9 degrader-6 | PROTAC CDK9 degrader-6 is a PROTAC targeting to CDK9 sepcifically. PROTAC CDK9 degrader-6 mediates CDK9 degradation via the proteasome. PROTAC CDK9 degrader-6 degrades CDK9 with DC50s of 0.10 μM and 0.14 μM for the CDK942 and CDK955 isoforms, respectively. | |||||||||||||||||||||
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