1. Cell Cycle/DNA Damage
  2. CDK
  3. CDK9-IN-9

CDK9-IN-9 

Cat. No.: HY-130001
Handling Instructions

CDK9-IN-9 (example 2) is a potent and selective CDK9 inhibitor with an IC50 of 1.8 nM. CDK9-IN-9 inhibits CDK2 with an IC50 of 155 nM. CDK9-IN-9 has anti-cancer activity.

For research use only. We do not sell to patients.

CDK9-IN-9 Chemical Structure

CDK9-IN-9 Chemical Structure

CAS No. : 2246956-84-1

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Description

CDK9-IN-9 (example 2) is a potent and selective CDK9 inhibitor with an IC50 of 1.8 nM. CDK9-IN-9 inhibits CDK2 with an IC50 of 155 nM. CDK9-IN-9 has anti-cancer activity[1].

IC50 & Target[1]

CDK9

1.8 nM (IC50)

CDK2

155 nM (IC50)

In Vitro

CDK9-IN-9 (example 2) inhibits the proliferation of HeLa, HeLa-MaTu-ADR, NCI-H460, DU145, Caco-2, B16F10, A2780 and MOLM-13 cells with IC50s of 4.4 nM, 5.3 nM, 9.2 nM, 4.5 nM, 8.4 nM, 1.2 nM, 1.2 nM, 2.0 nM, respectively[1].

Molecular Weight

459.51

Formula

C₂₂H₂₃F₂N₅O₂S

CAS No.

2246956-84-1

SMILES

CS(CC1=CC2=CC(NC3=NC=C(C(C4=CC=C(C(NCCCCO2)=C4)F)=N3)F)=C1)(=O)=N

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

CDK9-IN-9CDKCyclin dependent kinaseCDK9CDK2anti-canceractivityInhibitorinhibitorinhibit

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CDK9-IN-9
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