ABC1183

Cat. No.: HY-100950 Purity: 99.19%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

ABC1183 is an orally active selective dual GSK3 and CDK9 inhibitor. ABC1183 inhibits GSK3β, GSK3α and CDK9/cyclin T1 with the IC₅₀ values of 657 nM, 327 nM and 321 nM, respectively. ABC1183 has anti-inflammatory and anti-tumor activities.

For research use only. We do not sell to patients.

ABC1183 Chemical Structure

CAS No. : 1042735-18-1

Size	Price	Stock	Quantity

Free Sample (0.1 - 0.5 mg)		Apply Now
Solid + Solvent
10 mM * 1 mL in DMSO ready for reconstitution	USD 83	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 83	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 75	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 120	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 250	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 400	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 640	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Biological Activity
Purity & Documentation
Customer Review

Description

In Vitro

ABC1183 (3 μM, 24 h) can block cell cycle progression and thus affect cell proliferation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis^[1]

Cell Line:	LNCaP human prostate cancer cells
Concentration:	3 μM
Incubation Time:	24 hours
Result:	Significantly reduced cells in the G1 and S phases and increased cells in the G2/M and sub-G1 cycle phases.

In Vivo

ABC1183 (oral gavage, 5 or 50 mg/kg) inhibits tumor proliferation through negative regulation of cell growth and pro-inflammatory signalling in male C57BL/6 mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male C57BL/6 mice with melanoma B16^[1]
Dosage:	5 mg/kg
Administration:	Oral gavage; 5 times per week; 22 days
Result:	Reduced tumor size and no observed toxicity. Decreased the expression levels of GSK3 α /β, pSer21/9 and GS pSer641 but no change of total GS expression.

Animal Model:	Male C57BL/6 mice infected crohn’s disease^[1]
Dosage:	50 mg/kg
Administration:	Oral gavage; everyday; 3 days
Result:	Reduced TNF-α by 65%, IL-6 by 30% and IL-1β by 45%.

Animal Model:	Male C57BL/6 mice with ulcerative colitis^[1]
Dosage:	50 mg/kg
Administration:	Oral gavage; once daily; 6 days
Result:	Increased the expression of the anti-inflammatory factor IL-10, while decreasing the pro-inflammatory factor IL-6.

Molecular Weight

334.39

Formula

C₁₈H₁₄N₄OS

CAS No.

1042735-18-1

Appearance

Solid

Color

Light yellow to yellow

SMILES

N#CC1=CC=C(C(C2=C(N)N=C(NC3=CC=C(C)C=C3)S2)=O)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (373.82 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.9905 mL	14.9526 mL	29.9052 mL
5 mM	0.5981 mL	2.9905 mL	5.9810 mL
10 mM	0.2991 mL	1.4953 mL	2.9905 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.19%

Select Batch:

Data Sheet (276 KB) SDS (251 KB)

COA (249 KB) HNMR (254 KB) RP-HPLC (197 KB) MS (69 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.9905 mL	14.9526 mL	29.9052 mL	74.7630 mL
	5 mM	0.5981 mL	2.9905 mL	5.9810 mL	14.9526 mL
	10 mM	0.2991 mL	1.4953 mL	2.9905 mL	7.4763 mL
	15 mM	0.1994 mL	0.9968 mL	1.9937 mL	4.9842 mL
	20 mM	0.1495 mL	0.7476 mL	1.4953 mL	3.7381 mL
	25 mM	0.1196 mL	0.5981 mL	1.1962 mL	2.9905 mL
	30 mM	0.0997 mL	0.4984 mL	0.9968 mL	2.4921 mL
	40 mM	0.0748 mL	0.3738 mL	0.7476 mL	1.8691 mL
	50 mM	0.0598 mL	0.2991 mL	0.5981 mL	1.4953 mL
	60 mM	0.0498 mL	0.2492 mL	0.4984 mL	1.2460 mL
	80 mM	0.0374 mL	0.1869 mL	0.3738 mL	0.9345 mL
	100 mM	0.0299 mL	0.1495 mL	0.2991 mL	0.7476 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ABC11831042735-18-1ABC 1183ABC-1183Inhibitorinhibitorinhibit

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