1042735-18-1
1042735-18-1
Chemical Structure
ABC1183
- CAS No.: 1042735-18-1
- Formula:C18H14N4OS
- Molecular Weight:334.39
IUPAC Name: 4-(4-amino-2-(p-tolylamino)thiazole-5-carbonyl)benzonitrile
InChIKey: CUDLEXBIVZPJBU-UHFFFAOYSA-N
SMILES: N#CC1=CC=C(C(C2=C(N)N=C(NC3=CC=C(C)C=C3)S2)=O)C=C1
Biological Activity:
ABC1183 is an orally active selective dual GSK3 and CDK9 inhibitor. ABC1183 inhibits GSK3β, GSK3α and CDK9/cyclin T1 with the IC50 values of 657 nM, 327 nM and 321 nM, respectively. ABC1183 has anti-inflammatory and anti-tumor activities[1].
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ABC1183 | 99.62% | ABC1183 is an orally active selective dual GSK3 and CDK9 inhibitor. ABC1183 inhibits GSK3β, GSK3α and CDK9/cyclin T1 with the IC50 values of 657 nM, 327 nM and 321 nM, respectively. ABC1183 has anti-inflammatory and anti-tumor activities. |
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ABC1183 (Standard) | ≥98% | ABC1183 (Standard) is the analytical standard of ABC1183 (HY-100950). This product is intended for research and analytical applications. ABC1183 is an orally active selective dual GSK3 and CDK9 inhibitor. ABC1183 inhibits GSK3β, GSK3α and CDK9/cyclin T1 with the IC50 values of 657 nM, 327 nM and 321 nM, respectively. ABC1183 has anti-inflammatory and anti-tumor activities. |
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References
Keywords
