PROTAC CDK9 degrader-7
Based on 1 Customer Validation
PROTAC CDK9 degrader-7 is a PROTAC targeting to CDK9 sepcifically. PROTAC CDK9 degrader-7 mediates CDK9 degradation via the proteasome.
For research use only. We do not sell to patients.
- Purity: 99.62%
- CAS No.: 2935587-90-7
- Formula: C43H50Cl2N8O9
- Molecular Weight:893.81
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MOLM-13 | IC50 |
0.12 μM
Compound: 15f
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Anticancer activity against human MOLM-13 cells assessed as cell growth inhibition measured after 48 hrs by MTS assay
Anticancer activity against human MOLM-13 cells assessed as cell growth inhibition measured after 48 hrs by MTS assay
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[PMID: 37071962] |
PROTAC CDK9 degrader-7 (compound 15f) shows the great potency with an IC50 of 40 nM in the Molm-13 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MV411 cells
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Concentration:0.01 μM, 0.05 μM, 0.1 μM, 0.5 μM, 1 μM, 5 μM
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Incubation Time:6 h
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Result:Significantly decreased the protein level of MCL2, and almostly and competely degraded CKD9 at low concentration as 0.1 μM.
Chemical Information
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CAS No. 2935587-90-7
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Appearance Solid
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Molecular Weight 893.81
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Formula C43H50Cl2N8O9
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Color White to off-white
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SMILES
O=C(NCCCCCCCCCCCC(N1CCC(CC1)NC(C2=NNC=C2NC(C3=C(C=CC=C3Cl)Cl)=O)=O)=O)COC4=CC=CC5=C4C(N(C5=O)C6CCC(NC6=O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (111.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (269 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.1188 mL | 5.5940 mL | 11.1881 mL | 27.9702 mL |
| 5 mM | 0.2238 mL | 1.1188 mL | 2.2376 mL | 5.5940 mL | |
| 10 mM | 0.1119 mL | 0.5594 mL | 1.1188 mL | 2.7970 mL | |
| 15 mM | 0.0746 mL | 0.3729 mL | 0.7459 mL | 1.8647 mL | |
| 20 mM | 0.0559 mL | 0.2797 mL | 0.5594 mL | 1.3985 mL | |
| 25 mM | 0.0448 mL | 0.2238 mL | 0.4475 mL | 1.1188 mL | |
| 30 mM | 0.0373 mL | 0.1865 mL | 0.3729 mL | 0.9323 mL | |
| 40 mM | 0.0280 mL | 0.1399 mL | 0.2797 mL | 0.6993 mL | |
| 50 mM | 0.0224 mL | 0.1119 mL | 0.2238 mL | 0.5594 mL | |
| 60 mM | 0.0186 mL | 0.0932 mL | 0.1865 mL | 0.4662 mL | |
| 80 mM | 0.0140 mL | 0.0699 mL | 0.1399 mL | 0.3496 mL | |
| 100 mM | 0.0112 mL | 0.0559 mL | 0.1119 mL | 0.2797 mL |
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