CDK9-IN-48
CDK9-IN-48 is a CDK9 inhibitor with an IC50 of 1.37 nM. CDK9-IN-48 inhibits the proliferation of various cancer cells. CDK9-IN-48 can be used in the research of cancers such as acute myeloid leukemia and prostate cancer.
For research use only. We do not sell to patients.
- CAS No.: 2987897-20-9
- Formula: C23H24FN5O3S
- Molecular Weight:469.53
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
CDK9 1.37 nM (IC50) |
CDK9-IN-48 (Example 18) (0.00000256-1 μM, 3 days) potently inhibits the proliferation of MOLM-13 acute myeloid leukemia cells, LNCaP prostate cancer cells, and MV-4-11 acute myeloid leukemia cells, with IC50 values of 0.645, 2.34, and 2.24 nM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:MOLM-13, LNCaP, MV-4-11 cell
-
Concentration:0.00000256-1μM, starting with 1 μM, a 5-fold serial dilution was performed to obtain 9 concentrations
-
Incubation Time:2 days (post-compound addition, 37°C, 5% CO2)
-
Result:Potently inhibited MOLM-13 cell proliferation with an IC50 of 0.645 nM.
Inhibited LNCaP cell proliferation with an IC50 of 2.34 nM.
Inhibited MV-4-11 cell proliferation with an IC50 of 2.24 nM.
Chemical Information
-
CAS No. 2987897-20-9
-
Molecular Weight 469.53
-
Formula C23H24FN5O3S
-
SMILES
CN1C(C(C)(O)C)=C2C=C(C3=C(F)C=NC(NC4=CC(CS(C)(=O)=O)=CC=N4)=C3)C=CC2=N1
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz