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LARP7 - La ribonucleoprotein 7, transcriptional regulator Gene

Also Known as ALAZS; PIP7S; hLARP7; HDCMA18P

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 51574

About LARP7

Cytogenetic location: 4q25 Genomic coordinates (GRCh38): 4:112,637,143-112,657,586 (from NCBI)

This gene has 39 transcripts (splice variants), 223 orthologues, 6 paralogues and is associated with 3 phenotypes. Ubiquitous expression in lymph node (RPKM 17.7), thyroid (RPKM 16.5) and 25 other tissues.

Summary

This gene encodes a protein which is found in the 7SK snRNP (small nuclear ribonucleoprotein). This snRNP complex inhibits a cyclin-dependent kinase, positive transcription elongation factor b, which is required for paused RNA polymerase II at a promoter to begin transcription elongation. A pseudogene of this gene is located on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2012]

LARP7 Products (12)

mRNA	Protein	Name
NM_001267039.4	NP_001253968.2	la-related protein 7 isoform 1
NM_001370974.1	NP_001357903.1	la-related protein 7 isoform 3
NM_001370975.1	NP_001357904.1	la-related protein 7 isoform 3
NM_001370976.1	NP_001357905.1	la-related protein 7 isoform 4
NM_001370977.1	NP_001357906.1	la-related protein 7 isoform 4
NM_001370978.1	NP_001357907.1	la-related protein 7 isoform 1
NM_001370979.1	NP_001357908.1	la-related protein 7 isoform 5
NM_001370980.1	NP_001357909.1	la-related protein 7 isoform 5
NM_001370981.1	NP_001357910.1	la-related protein 7 isoform 6
NM_001370982.1	NP_001357911.1	la-related protein 7 isoform 6
NM_015454.3	NP_056269.1	la-related protein 7 isoform 1
NM_016648.4	NP_057732.2	la-related protein 7 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables 7SK snRNA binding	IDA IDA: Inferred from direct assay	18249148	GOA
enables U6 snRNA binding	IDA IDA: Inferred from direct assay	32017898	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18281698	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in U6 2'-O-snRNA methylation	IMP IMP: Inferred from mutant phenotype	32017898	GOA
involved in box C/D sno(s)RNA 3'-end processing	IMP IMP: Inferred from mutant phenotype	32017898	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	18483487	GOA
involved in negative regulation of viral transcription	IMP IMP: Inferred from mutant phenotype	18249148	GOA
involved in positive regulation of protein localization to Cajal body	IDA IDA: Inferred from direct assay	28254838	GOA
involved in positive regulation of snRNA transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	28254838	GOA
involved in regulation of mRNA splicing, via spliceosome	IMP IMP: Inferred from mutant phenotype	32017898	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of 7SK snRNP	IDA IDA: Inferred from direct assay	18249148	GOA
located in nucleus	IDA IDA: Inferred from direct assay	28254838	GOA
part of ribonucleoprotein complex	IDA IDA: Inferred from direct assay	19906723	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LARP7 Protein Structure

RRM_1

RRM_3

0
100
200
300
400
500
582 a.a.

Protein Preferred Names	Protein Names
la-related protein 7	La ribonucleoprotein domain family member 7

LARP7 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	LARP7	Q4G0J3	CDK9	Homo sapiens	P50750	Anti Tag CoIP	35271311
Intra	LARP7	Q4G0J3	CDK9	Homo sapiens	P50750	Pull Down	18483487
Intra	LARP7	Q4G0J3	CDK9	Homo sapiens	P50750	Anti Tag CoIP	33961781
Intra	LARP7	Q4G0J3	CDK9	Homo sapiens	P50750	TAP	18281698
Intra	LARP7	Q4G0J3	CDK9	Homo sapiens	P50750	Anti Bait CoIP	18483487
Intra	LARP7	Q4G0J3	CDK9	Homo sapiens	P50750	Anti Bait CoIP	18281698
Intra	LARP7	Q4G0J3	HEXIM1	Homo sapiens	O94992	Anti Tag CoIP	35271311
Intra	LARP7	Q4G0J3	HEXIM1	Homo sapiens	O94992	Anti Bait CoIP	18281698
Intra	LARP7	Q4G0J3	HEXIM1	Homo sapiens	O94992	TAP	18281698
Intra	LARP7	Q4G0J3	HEXIM1	Homo sapiens	O94992	Anti Tag CoIP	33961781
Intra	LARP7	Q4G0J3	HEXIM1	Homo sapiens	O94992	Anti Bait CoIP	18483487
Intra	LARP7	Q4G0J3	DDX21	Homo sapiens	Q9NR30	Anti Tag CoIP	33961781
Intra	LARP7	Q4G0J3	OASL	Homo sapiens	Q15646	Pull Down	30833792
Intra	LARP7	Q4G0J3	LRRK2	Homo sapiens	Q5S007	Protein Array	29513927

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Alazami Syndrome	Microcephalic Primordial Dwarfism, Alazami Type ALAZS Facial Dysmorphism, Intellectual Disability, And Primordial Dwarfism Facial Dysmorphism Intellectual Disability And Primordial Dwarfism
Smith-Lemli-Opitz Syndrome	SLOS Rsh Syndrome 7-Dehydrocholesterol Reductase Deficiency Slo Syndrome Rutledge Lethal Multiple Congenital Anomaly Syndrome Lethal Acrodysgenital Syndrome Polydactyly, Sex Reversal, Renal Hypoplasia, And Unilobar Lung Smith-Opitz-Inborn Syndrome Polydactyly, Sex Reversal, Renal Hypoplasia, And Unilobular Lung Smith Lemli Opitz Syndrome Smith-Lemli-Opitz Syndrome, Type Ii
Coffin-Siris Syndrome 9	Mrd27 CSS9 Mental Retardation, Autosomal Dominant 27 Autosomal Dominant Mental Retardation 27 Autosomal Dominant Non-Syndromic Intellectual Disability 27 Coffin-Siris Syndrome, Type 9
Isolated Growth Hormone Deficiency, Type Ia	Ighd Ia Primordial Dwarfism Isolated Growth Hormone Deficiency Type Ia Sexual Ateleiotic Dwarfism Pituitary Dwarfism I IGHD1A Illig-Type Growth Hormone Deficiency Growth Hormone Deficiency, Isolated, Type Ia Congenital Ighd Type Ia Congenital Isolated Gh Deficiency Type Ia Congenital Isolated Growth Hormone Deficiency Type Ia Pituitary Dwarfism 1 Growth Hormone Deficiency, Isolated, Autosomal Recessive Autosomal Recessive Isolated Growth Hormone Deficiency Isolated Growth Hormone Deficiency Type 1a Congenital Ighd Congenital Isolated Gh Deficiency Congenital Isolated Growth Hormone Deficiency Growth Hormone Deficiency, Isolated Autosomal Recessive Illig Type Growth Hormone Deficiency Non-Acquired Isolated Growth Hormone Deficiency Growth Hormone Deficiency, Isolated, 1a Growth Hormone Deficiency Isolated Autosomal Recessive Dwarfism, Primordial Dwarfism

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07531	LARP7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20441	Larp7 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26950	Larp7 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	LARP7	VGNC	VGNC:42591
Rattus norvegicus	LARP7	RGD	RGD:1592474
Felis catus	LARP7	VGNC	VGNC:63196
Macaca mulatta	LARP7	VGNC	VGNC:74118
Mus musculus	LARP7	MGD	MGI:107634
Bos taurus	LARP7	VGNC	VGNC:30794
Others	LARP7	NCBI