OASL - 2'-5'-oligoadenylate synthetase like Gene

Homo sapiens

Also known as OASL1; OASLd; TRIP14; TRIP-14; p59OASL; p59 OASL; p59-OASL

Gene ID: 8638 | Gene type: protein coding

About OASL

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:121,017,761-121,039,246 (from NCBI)

This gene has 11 transcripts (splice variants), 123 orthologues and 3 paralogues. Biased expression in bone marrow (RPKM 19.8), stomach (RPKM 11.1) and 13 other tissues.

Summary

Enables DNA binding activity and double-stranded RNA binding activity. Involved in several processes, including interleukin-27-mediated signaling pathway; negative regulation of viral genome replication; and positive regulation of RIG-I signaling pathway. Located in cytosol; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

OASL Products(5)

mRNA	Protein	Name
NM_001261825.2	NP_001248754.1	2'-5'-oligoadenylate synthase-like protein isoform c
NM_001395418.1	NP_001382347.1	2'-5'-oligoadenylate synthase-like protein isoform b
NM_001395419.1	NP_001382348.1	2'-5'-oligoadenylate synthase-like protein isoform d
NM_003733.4	NP_003724.1	2'-5'-oligoadenylate synthase-like protein isoform a
NM_198213.3	NP_937856.1	2'-5'-oligoadenylate synthase-like protein isoform b

OASL Protein Structure

OAS1_C

ubiquitin

0
100
200
300
400
514 a.a.

Protein Preferred Names

Protein Names

2'-5'-oligoadenylate synthase-like protein

2'-5'-OAS-RP

Related Diseases

Diseases

Alias

Microphthalmia With Limb Anomalies

Waardenburg Anophthalmia Syndrome	Ophthalmoacromelic Syndrome
OAS	MLA
Anophthalmia-Syndactyly	Anophthalmia-Syndactyly Syndrome
Anophthalmos With Limb Anomalies	Anophthalmia Waardenburg Syndrome
Anophthalmos-Syndactyly	Ophthalmo-Acromelic Syndrome
Anophthalmia-Waardenburg Syndrome	Anophthalmos-Limb Anomalies Syndrome
Syndactyly-Anophthalmos Syndrome	Microphthalmia, With Limb Anomalies

West Nile Fever

Aicardi-Goutieres Syndrome

Aicardi Goutieres Syndrome	Cree Encephalitis
Aicardi-Goutières Syndrome	Encephalopathy With Basal Ganglia Calcification
Ags	Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid
Pseudotoxoplasmosis Syndrome	Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis
Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis	Aicardi-Goutieres Syndrome 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09730	OASL Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	OASL	VGNC	VGNC:32392
Canis familiaris	OASL	VGNC	VGNC:44089
Mus musculus	OASL	MGD	MGI:2180849
Rattus norvegicus	OASL	RGD	RGD:1308586
Macaca mulatta	OASL	VGNC	VGNC:75572

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