OASL - 2'-5'-oligoadenylate synthetase like Gene

Also Known as OASL1; OASLd; TRIP14; TRIP-14; p59OASL; p59 OASL; p59-OASL

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8638

About OASL

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:121,017,761-121,039,246 (from NCBI)

This gene has 11 transcripts (splice variants), 123 orthologues and 3 paralogues. Biased expression in bone marrow (RPKM 19.8), stomach (RPKM 11.1) and 13 other tissues.

Summary

Enables DNA binding activity and double-stranded RNA binding activity. Involved in several processes, including interleukin-27-mediated signaling pathway; negative regulation of viral genome replication; and positive regulation of RIG-I signaling pathway. Located in cytosol; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

OASL Products (5)

mRNA	Protein	Name
NM_001261825.2	NP_001248754.1	2'-5'-oligoadenylate synthase-like protein isoform c
NM_001395418.1	NP_001382347.1	2'-5'-oligoadenylate synthase-like protein isoform b
NM_001395419.1	NP_001382348.1	2'-5'-oligoadenylate synthase-like protein isoform d
NM_003733.4	NP_003724.1	2'-5'-oligoadenylate synthase-like protein isoform a
NM_198213.3	NP_937856.1	2'-5'-oligoadenylate synthase-like protein isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
NOT enables 2'-5'-oligoadenylate synthetase activity	IDA IDA: Inferred from direct assay	9826176	GOA
enables DNA binding	IDA IDA: Inferred from direct assay	9826176	GOA
enables double-stranded RNA binding	IDA IDA: Inferred from direct assay	9826176	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	30833792	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in defense response to virus	IDA IDA: Inferred from direct assay	21478870	GOA
involved in interleukin-27-mediated signaling pathway	IEP IEP: Inferred from expression pattern	32270034	GOA
involved in negative regulation of viral genome replication	IDA IDA: Inferred from direct assay	18931074	GOA
involved in positive regulation of RIG-I signaling pathway	IDA IDA: Inferred from direct assay	25925578	GOA
involved in response to virus	IDA IDA: Inferred from direct assay	18931074	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	9826176	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	9826176	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OASL Protein Structure

OAS1_C

ubiquitin

0
100
200
300
400
514 a.a.

Protein Preferred Names	Protein Names
2'-5'-oligoadenylate synthase-like protein	2'-5'-OAS-RP

OASL Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	OASL	Q15646	LARP7	Homo sapiens	Q4G0J3	Anti Tag CoIP	33961781
Intra	OASL	Q15646	LARP7	Homo sapiens	Q4G0J3	Pull Down	30833792

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Microphthalmia With Limb Anomalies	Waardenburg Anophthalmia Syndrome Ophthalmoacromelic Syndrome OAS MLA Anophthalmia-Syndactyly Anophthalmia-Syndactyly Syndrome Anophthalmos With Limb Anomalies Anophthalmia Waardenburg Syndrome Anophthalmos-Syndactyly Ophthalmo-Acromelic Syndrome Anophthalmia-Waardenburg Syndrome Anophthalmos-Limb Anomalies Syndrome Syndactyly-Anophthalmos Syndrome Microphthalmia, With Limb Anomalies
West Nile Fever
Aicardi-Goutieres Syndrome	Aicardi Goutieres Syndrome Cree Encephalitis Aicardi-Goutières Syndrome Encephalopathy With Basal Ganglia Calcification Ags Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid Pseudotoxoplasmosis Syndrome Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis Aicardi-Goutieres Syndrome 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09730	OASL Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26120	Oasl Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	OASL	VGNC	VGNC:32392
Canis familiaris	OASL	VGNC	VGNC:44089
Mus musculus	OASL	MGD	MGI:2180849
Rattus norvegicus	OASL	RGD	RGD:1308586
Macaca mulatta	OASL	VGNC	VGNC:75572
Others	OASL	NCBI