LRRK2 - leucine rich repeat kinase 2 Gene

Also Known as PARK8; RIPK7; ROCO2; AURA17; DARDARIN

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 120892

About LRRK2

Cytogenetic location: 12q12 Genomic coordinates (GRCh38): 12:40,224,997-40,369,285 (from NCBI)

This gene has 21 transcripts (splice variants), 191 orthologues, 23 paralogues and is associated with 3 phenotypes. Broad expression in lung (RPKM 31.3), appendix (RPKM 7.6) and 15 other tissues.

Summary

This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a Ras domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8. [provided by RefSeq, Jul 2008]

LRRK2 Products (12)

mRNA	Protein	Name
XR_007063041.1
NM_198578.4	NP_940980.4	leucine-rich repeat serine/threonine-protein kinase 2
XM_024448833.2	XP_024304601.1	leucine-rich repeat serine/threonine-protein kinase 2 isoform X5
XM_011537877.4	XP_011536179.1	leucine-rich repeat serine/threonine-protein kinase 2 isoform X2
XM_047428278.1	XP_047284234.1	leucine-rich repeat serine/threonine-protein kinase 2 isoform X4
XM_047428277.1	XP_047284233.1	leucine-rich repeat serine/threonine-protein kinase 2 isoform X3
XM_017018787.2	XP_016874276.1	leucine-rich repeat serine/threonine-protein kinase 2 isoform X9
XM_017018786.3	XP_016874275.1	leucine-rich repeat serine/threonine-protein kinase 2 isoform X8
XM_011537881.4	XP_011536183.1	leucine-rich repeat serine/threonine-protein kinase 2 isoform X7
XM_005268629.5	XP_005268686.1	leucine-rich repeat serine/threonine-protein kinase 2 isoform X1
XM_011537882.4	XP_011536184.1	leucine-rich repeat serine/threonine-protein kinase 2 isoform X10
XM_047428279.1	XP_047284235.1	leucine-rich repeat serine/threonine-protein kinase 2 isoform X6

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables GTP binding	IDA IDA: Inferred from direct assay	16980962	GOA
enables GTP-dependent protein kinase activity	IDA IDA: Inferred from direct assay	17260967	GOA
enables GTP-dependent protein kinase activity	IMP IMP: Inferred from mutant phenotype	17200152	GOA
enables GTPase activator activity	IDA IDA: Inferred from direct assay	17442267	GOA
enables GTPase activity	IDA IDA: Inferred from direct assay	21048939	GOA
enables JUN kinase kinase kinase activity	IDA IDA: Inferred from direct assay	19302196	GOA
enables MAP kinase kinase kinase activity	IDA IDA: Inferred from direct assay	19302196	GOA
enables SNARE binding	IPI IPI: Inferred from physical interaction	21307259	GOA
enables actin binding	IPI IPI: Inferred from physical interaction	21307259	GOA
enables clathrin binding	IPI IPI: Inferred from physical interaction	21307259	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	16321986	GOA
enables kinase activity	IDA IDA: Inferred from direct assay	17114044	GOA
enables kinase activity	IMP IMP: Inferred from mutant phenotype	23916833	GOA
enables magnesium ion binding	IMP IMP: Inferred from mutant phenotype	28720718	GOA
enables peroxidase inhibitor activity	IDA IDA: Inferred from direct assay	21850687	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16321986	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	16321986	GOA
enables protein kinase A binding	IPI IPI: Inferred from physical interaction	24464040	GOA
enables protein kinase activity	IDA IDA: Inferred from direct assay	16269541	GOA
enables protein serine/threonine kinase activity	EXP EXP: Inferred from Experiment	26751287	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	17200152	GOA
enables protein serine/threonine kinase activity	IMP IMP: Inferred from mutant phenotype	28720718	GOA
enables signaling receptor complex adaptor activity	IDA IDA: Inferred from direct assay	22899650	GOA
enables small GTPase binding	IPI IPI: Inferred from physical interaction	21048939	GOA
enables syntaxin-1 binding	IPI IPI: Inferred from physical interaction	21307259	GOA
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	21370995	GOA
enables tubulin binding	IDA IDA: Inferred from direct assay	21159966	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in GTP metabolic process	IDA IDA: Inferred from direct assay	21048939	GOA
involved in Golgi organization	IMP IMP: Inferred from mutant phenotype	24510904	GOA
involved in JNK cascade	IDA IDA: Inferred from direct assay	19302196	GOA
involved in MAPK cascade	IDA IDA: Inferred from direct assay	17200152	GOA
involved in Rho protein signal transduction	IDA IDA: Inferred from direct assay	25500533	GOA
involved in Wnt signalosome assembly	IPI IPI: Inferred from physical interaction	22899650	GOA
involved in calcium-mediated signaling	IMP IMP: Inferred from mutant phenotype	25416817	GOA
involved in cellular response to dopamine	IMP IMP: Inferred from mutant phenotype	23628791	GOA
involved in cellular response to manganese ion	IMP IMP: Inferred from mutant phenotype	23628791	GOA
involved in cellular response to oxidative stress	IMP IMP: Inferred from mutant phenotype	21362567	GOA
involved in cellular response to reactive oxygen species	IMP IMP: Inferred from mutant phenotype	24576675	GOA
involved in cellular response to starvation	IMP IMP: Inferred from mutant phenotype	24211199	GOA
involved in determination of adult lifespan	IMP IMP: Inferred from mutant phenotype	19692353	GOA
involved in endocytosis	IGI IGI: Inferred from genetic interaction	24576675	GOA
involved in endocytosis	IMP IMP: Inferred from mutant phenotype	24576675	GOA
involved in endoplasmic reticulum organization	IMP IMP: Inferred from mutant phenotype	25201882	GOA
involved in exploration behavior	IMP IMP: Inferred from mutant phenotype	20659558	GOA
involved in intracellular distribution of mitochondria	IMP IMP: Inferred from mutant phenotype	21159966	GOA
involved in lysosome organization	IMP IMP: Inferred from mutant phenotype	25416817	GOA
involved in mitochondrion localization	IMP IMP: Inferred from mutant phenotype	22764206	GOA
involved in mitochondrion organization	IMP IMP: Inferred from mutant phenotype	22764206	GOA
acts upstream of or within negative regulation of GTPase activity	IDA IDA: Inferred from direct assay	22423108	GOA
involved in negative regulation of autophagosome assembly	IMP IMP: Inferred from mutant phenotype	23916833	GOA
involved in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	21857923	GOA
involved in negative regulation of macroautophagy	IMP IMP: Inferred from mutant phenotype	19640926	GOA
involved in negative regulation of protein binding	IMP IMP: Inferred from mutant phenotype	23949442	GOA
involved in negative regulation of protein processing	IDA IDA: Inferred from direct assay	21370995	GOA
involved in negative regulation of protein targeting to mitochondrion	IDA IDA: Inferred from direct assay	21370995	GOA
involved in negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation	IDA IDA: Inferred from direct assay	21850687	GOA
involved in neuromuscular junction development	IMP IMP: Inferred from mutant phenotype	21159966	GOA
involved in neuron projection morphogenesis	IMP IMP: Inferred from mutant phenotype	17114044	GOA
involved in olfactory bulb development	IMP IMP: Inferred from mutant phenotype	21168496	GOA
involved in peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	19576176	GOA
involved in peptidyl-threonine phosphorylation	IDA IDA: Inferred from direct assay	21048939	GOA
involved in peptidyl-threonine phosphorylation	IMP IMP: Inferred from mutant phenotype	23949442	GOA
involved in phosphorylation	IMP IMP: Inferred from mutant phenotype	23916833	GOA
involved in positive regulation of MAP kinase activity	IMP IMP: Inferred from mutant phenotype	21857923	GOA
involved in positive regulation of autophagy	IMP IMP: Inferred from mutant phenotype	22012985	GOA
involved in positive regulation of canonical Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	22899650	GOA
involved in positive regulation of dopamine receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	20659558	GOA
involved in positive regulation of programmed cell death	IDA IDA: Inferred from direct assay	17200152	GOA
involved in positive regulation of protein autoubiquitination	IDA IDA: Inferred from direct assay	16352719	GOA
involved in positive regulation of protein binding	IDA IDA: Inferred from direct assay	21370995	GOA
involved in positive regulation of protein kinase activity	IDA IDA: Inferred from direct assay	19302196	GOA
involved in positive regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	22012985	GOA
involved in positive regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	20659558	GOA
involved in positive regulation of protein ubiquitination	IDA IDA: Inferred from direct assay	16352719	GOA
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	16269541	GOA
involved in protein autophosphorylation	IMP IMP: Inferred from mutant phenotype	16980962	GOA
involved in protein localization to endoplasmic reticulum exit site	IMP IMP: Inferred from mutant phenotype	25201882	GOA
involved in protein phosphorylation	IMP IMP: Inferred from mutant phenotype	23628791	GOA
involved in regulation of CAMKK-AMPK signaling cascade	IMP IMP: Inferred from mutant phenotype	22012985	GOA
involved in regulation of autophagy	IMP IMP: Inferred from mutant phenotype	24211199	GOA
involved in regulation of branching morphogenesis of a nerve	IMP IMP: Inferred from mutant phenotype	21168496	GOA
involved in regulation of dendritic spine morphogenesis	IMP IMP: Inferred from mutant phenotype	21168496	GOA
involved in regulation of locomotion	IMP IMP: Inferred from mutant phenotype	19692353	GOA
involved in regulation of lysosomal lumen pH	IMP IMP: Inferred from mutant phenotype	22012985	GOA
involved in regulation of membrane potential	IMP IMP: Inferred from mutant phenotype	21159966	GOA
involved in regulation of mitochondrial depolarization	IMP IMP: Inferred from mutant phenotype	22736029	GOA
involved in regulation of neuroblast proliferation	IMP IMP: Inferred from mutant phenotype	21168496	GOA
involved in regulation of neuron maturation	IMP IMP: Inferred from mutant phenotype	21168496	GOA
involved in regulation of protein stability	IMP IMP: Inferred from mutant phenotype	26014385	GOA
involved in regulation of reactive oxygen species metabolic process	IMP IMP: Inferred from mutant phenotype	24576675	GOA
involved in regulation of retrograde transport, endosome to Golgi	IGI IGI: Inferred from genetic interaction	23395371	GOA
involved in regulation of synaptic vesicle exocytosis	IMP IMP: Inferred from mutant phenotype	23949442	GOA
involved in response to oxidative stress	IMP IMP: Inferred from mutant phenotype	19692353	GOA
involved in tangential migration from the subventricular zone to the olfactory bulb	IMP IMP: Inferred from mutant phenotype	21168496	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	23395371	GOA
located in Golgi-associated vesicle	IDA IDA: Inferred from direct assay	24510904	GOA
part of Wnt signalosome	IDA IDA: Inferred from direct assay	22899650	GOA
located in amphisome	IDA IDA: Inferred from direct assay	19640926	GOA
located in autolysosome	IDA IDA: Inferred from direct assay	19640926	GOA
located in axon	IDA IDA: Inferred from direct assay	17120249	GOA
located in caveola neck	IDA IDA: Inferred from direct assay	19640926	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	16321986	GOA
located in cytoplasm	IMP IMP: Inferred from mutant phenotype	26014385	GOA
located in cytoplasmic side of mitochondrial outer membrane	IDA IDA: Inferred from direct assay	16269541	GOA
located in cytosol	IDA IDA: Inferred from direct assay	21850687	GOA
located in dendrite	IDA IDA: Inferred from direct assay	17120249	GOA
located in dendrite cytoplasm	IDA IDA: Inferred from direct assay	21696411	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	19640926	GOA
located in endoplasmic reticulum exit site	IDA IDA: Inferred from direct assay	25201882	GOA
located in growth cone	IDA IDA: Inferred from direct assay	19625296	GOA
located in microvillus	IDA IDA: Inferred from direct assay	19640926	GOA
located in mitochondrial membrane	IDA IDA: Inferred from direct assay	22736029	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	21850687	GOA
located in multivesicular body, internal vesicle	IDA IDA: Inferred from direct assay	19640926	GOA
located in neuron projection	IDA IDA: Inferred from direct assay	19625296	GOA
located in neuronal cell body	IDA IDA: Inferred from direct assay	21048939	GOA
located in perikaryon	IDA IDA: Inferred from direct assay	17120249	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	22899650	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LRRK2 Protein Structure

LRR_8

LRR_1

LRR_4

Roc

Pkinase

0
400
800
1200
1600
2000
2400
2527 a.a.

Protein Preferred Names	Protein Names
leucine-rich repeat serine/threonine-protein kinase 2	augmented in rheumatoid arthritis 17

LRRK2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	LRRK2	Q5S007	CSNK1A1	Homo sapiens	P48729-1	Protein Kinase Assay	25500533
Intra	LRRK2	Q5S007	AP3B1	Homo sapiens	O00203	Anti Tag CoIP	27424887
Intra	LRRK2	Q5S007	AP3B1	Homo sapiens	O00203	TAP	24725412
Intra	LRRK2	Q5S007	USP39	Homo sapiens	Q53GS9	Anti Tag CoIP	31046837
Intra	LRRK2	Q5S007	RAB1B	Homo sapiens	Q9H0U4	Anti Tag CoIP	31046837
Intra	LRRK2	Q5S007	RAB1B	Homo sapiens	Q9H0U4	Protein Kinase Assay	26824392
Intra	LRRK2	Q5S007	RAB1B	Homo sapiens	Q9H0U4	Protein Kinase Assay	32227113
Intra	LRRK2	Q5S007	CFAP20	Homo sapiens	Q9Y6A4	Anti Tag CoIP	31046837
Intra	LRRK2	Q5S007	RPS11	Homo sapiens	P62280	TAP	24725412
Intra	LRRK2	Q5S007	RPS11	Homo sapiens	P62280	Anti Tag CoIP	31046837
Intra	LRRK2	Q5S007	RPS11	Homo sapiens	P62280	Protein Kinase Assay	24725412
Intra	LRRK2	Q5S007	PPP2R2A	Homo sapiens	P63151	Anti Tag CoIP	31046837
Intra	LRRK2	Q5S007	PPP2R2A	Homo sapiens	P63151	Pull Down	26894577
Intra	LRRK2	Q5S007	PPP2R2A	Homo sapiens	P63151	Anti Tag CoIP	26894577
Intra	LRRK2	Q5S007	LRRK1	Homo sapiens	Q38SD2	Anti Tag CoIP	20144646
Intra	LRRK2	Q5S007	ZRANB2	Homo sapiens	O95218	Anti Tag CoIP	23075850
Intra	LRRK2	Q5S007	RPL34	Homo sapiens	P49207	Anti Tag CoIP	31046837
Intra	LRRK2	Q5S007	PAK6	Homo sapiens	Q9NQU5	Protein Array	24510904
Intra	LRRK2	Q5S007	OPA1	Homo sapiens	O60313	Anti Tag CoIP	31046837
Intra	LRRK2	Q5S007	OPA1	Homo sapiens	O60313	Anti Tag CoIP	24282027
Intra	LRRK2	Q5S007	TTC27	Homo sapiens	Q6P3X3	Anti Tag CoIP	31046837
Intra	LRRK2	Q5S007	WSB1	Homo sapiens	Q9Y6I7	Anti Tag CoIP	27273569
Intra	LRRK2	Q5S007	WSB1	Homo sapiens	Q9Y6I7	Y2H	27273569
Intra	LRRK2	Q5S007	MRPL19	Homo sapiens	P49406	Anti Tag CoIP	31046837
Intra	LRRK2	Q5S007	AHCYL1	Homo sapiens	O43865	Anti Tag CoIP	31046837
Intra	LRRK2	Q5S007	LARP7	Homo sapiens	Q4G0J3	Anti Tag CoIP	31046837
Intra	LRRK2	Q5S007	NDUFAF7	Homo sapiens	Q7L592	Protein Array	24510904
Intra	LRRK2	Q5S007	LARP4	Homo sapiens	Q71RC2	Anti Tag CoIP	31046837
Intra	LRRK2	Q5S007	CDC37	Homo sapiens	Q16543	Anti Tag CoIP	23075850
Intra	LRRK2	Q5S007	CDC37	Homo sapiens	Q16543	Affinity Chrom	16321986
Intra	LRRK2	Q5S007	CDC37	Homo sapiens	Q16543	Anti Tag CoIP	31046837
Intra	LRRK2	Q5S007	CDC37	Homo sapiens	Q16543	Anti Tag CoIP	20642453
Intra	LRRK2	Q5S007	CDC37	Homo sapiens	Q16543	Anti Tag CoIP	22612223
Intra	LRRK2	Q5S007	NUP133	Homo sapiens	Q8WUM0	TAP	24725412
Intra	LRRK2	Q5S007	NUP133	Homo sapiens	Q8WUM0	Anti Tag CoIP	31046837
Intra	LRRK2	Q5S007	AKT1	Homo sapiens	P31749	Pull Down	21658387
Intra	LRRK2	Q5S007	AKT1	Homo sapiens	P31749	Protein Kinase Assay	21658387
Intra	LRRK2	Q5S007	SNAPIN	Homo sapiens	O95295	Anti Bait CoIP	23949442
Intra	LRRK2	Q5S007	SNAPIN	Homo sapiens	O95295	Protein Kinase Assay	23949442
Intra	LRRK2	Q5S007	YWHAH	Homo sapiens	Q04917	Anti Tag CoIP	29541021
Intra	LRRK2	Q5S007	YWHAH	Homo sapiens	Q04917	Pull Down	20642453
Intra	LRRK2	Q5S007	YWHAH	Homo sapiens	Q04917	Anti Tag CoIP	23075850
Intra	LRRK2	Q5S007	YWHAH	Homo sapiens	Q04917	Anti Tag CoIP	20642453
Intra	LRRK2	Q5S007	YWHAH	Homo sapiens	Q04917	Anti Tag CoIP	31046837
Intra	LRRK2	Q5S007	SQSTM1	Homo sapiens	Q13501	Anti Tag CoIP	29519959
Intra	LRRK2	Q5S007	SQSTM1	Homo sapiens	Q13501	Pull Down	29519959
Intra	LRRK2	Q5S007	SQSTM1	Homo sapiens	Q13501	IF	29519959
Intra	LRRK2	Q5S007	SQSTM1	Homo sapiens	Q13501	Protein Kinase Assay	29519959
Intra	LRRK2	Q5S007	SQSTM1	Homo sapiens	Q13501	PLA	29519959
Intra	LRRK2	Q5S007	SQSTM1	Homo sapiens	Q13501	Anti Bait CoIP	29519959
Intra	LRRK2	Q5S007	MFN2	Homo sapiens	O95140	Anti Tag CoIP	24282027
Intra	LRRK2	Q5S007	YWHAZ	Homo sapiens	P63104	Anti Tag CoIP	20642453
Intra	LRRK2	Q5S007	YWHAZ	Homo sapiens	P63104	Pull Down	20642453
Intra	LRRK2	Q5S007	YWHAZ	Homo sapiens	P63104	Anti Tag CoIP	23075850
Intra	LRRK2	Q5S007	YWHAZ	Homo sapiens	P63104	Protein Array	24510904
Intra	LRRK2	Q5S007	YWHAZ	Homo sapiens	P63104	Anti Tag CoIP	31046837
Intra	LRRK2	Q5S007	TUBB	Homo sapiens	P07437	Anti Tag CoIP	24947832
Intra	LRRK2	Q5S007	TUBB	Homo sapiens	P07437	Y2H	24275654
Intra	LRRK2	Q5S007	TUBB	Homo sapiens	P07437	Pull Down	24275654
Intra	LRRK2	Q5S007	TUBB	Homo sapiens	P07437	Anti Tag CoIP	31046837
Intra	LRRK2	Q5S007	RPS3	Homo sapiens	P23396	Protein Kinase Assay	24725412
Intra	LRRK2	Q5S007	RPS3	Homo sapiens	P23396	Anti Tag CoIP	31046837
Intra	LRRK2	Q5S007	RPS3	Homo sapiens	P23396	TAP	24725412
Intra	LRRK2	Q5S007	TUBB4B	Homo sapiens	P68371	Anti Tag CoIP	31046837
Intra	LRRK2	Q5S007	TUBB4B	Homo sapiens	P68371	Y2H	24275654
Intra	LRRK2	Q5S007	CORO1C	Homo sapiens	Q9ULV4	Anti Tag CoIP	33938021
Intra	LRRK2	Q5S007	RPS13	Homo sapiens	P62277	Anti Tag CoIP	31046837
Intra	LRRK2	Q5S007	RPS13	Homo sapiens	P62277	Protein Kinase Assay	24725412
Intra	LRRK2	Q5S007	HSPA8	Homo sapiens	P11142	Anti Tag CoIP	17400507
Intra	LRRK2	Q5S007	HSPA8	Homo sapiens	P11142	Anti Tag CoIP	29519959
Intra	LRRK2	Q5S007	HSPA8	Homo sapiens	P11142	Anti Tag CoIP	24510904
Intra	LRRK2	Q5S007	HSPA8	Homo sapiens	P11142	Anti Tag CoIP	24947832
Intra	LRRK2	Q5S007	RPS18	Homo sapiens	P62269	Anti Tag CoIP	31046837
Intra	LRRK2	Q5S007	RPS16	Homo sapiens	P62249	TAP	24725412
Intra	LRRK2	Q5S007	RPS16	Homo sapiens	P62249	Anti Tag CoIP	31046837
Intra	LRRK2	Q5S007	RPS23	Homo sapiens	P62266	Protein Kinase Assay	24725412
Intra	LRRK2	Q5S007	RPS23	Homo sapiens	P62266	TAP	24725412
Intra	LRRK2	Q5S007	RPS20	Homo sapiens	P60866	Anti Tag CoIP	31046837
Intra	LRRK2	Q5S007	RPS20	Homo sapiens	P60866	TAP	24725412
Intra	LRRK2	Q5S007	RPL30	Homo sapiens	P62888	Anti Tag CoIP	31046837
Intra	LRRK2	Q5S007	RPL23A	Homo sapiens	P62750	Protein Kinase Assay	24725412
Intra	LRRK2	Q5S007	RPL23A	Homo sapiens	P62750	TAP	24725412
Intra	LRRK2	Q5S007	VDAC1	Homo sapiens	P21796	Anti Tag CoIP	31046837
Intra	LRRK2	Q5S007	EEF1A2	Homo sapiens	Q05639	Protein Kinase Assay	19559761
Intra	LRRK2	Q5S007	EEF1A2	Homo sapiens	Q05639	Anti Tag CoIP	31046837
Intra	LRRK2	Q5S007	TUBB4A	Homo sapiens	P04350	Anti Tag CoIP	31046837
Intra	LRRK2	Q5S007	TUBB4A	Homo sapiens	P04350	Y2H	24275654
Intra	LRRK2	Q5S007	TUBB4A	Homo sapiens	P04350	Pull Down	24275654
Intra	LRRK2	Q5S007	SLC25A5	Homo sapiens	P05141	TAP	24725412
Intra	LRRK2	Q5S007	BAG2	Homo sapiens	O95816	Protein Array	24510904
Intra	LRRK2	Q5S007	SLC25A6	Homo sapiens	P12236	Anti Tag CoIP	21370995
Intra	LRRK2	Q5S007	SLC25A6	Homo sapiens	P12236	TAP	24725412
Intra	LRRK2	Q5S007	RPS27	Homo sapiens	P42677	Anti Tag CoIP	31046837
Intra	LRRK2	Q5S007	RPS27	Homo sapiens	P42677	TAP	24725412
Intra	LRRK2	Q5S007	RPS27	Homo sapiens	P42677	Protein Kinase Assay	24725412
Intra	LRRK2	Q5S007	YWHAE	Homo sapiens	P62258	Anti Tag CoIP	24947832
Intra	LRRK2	Q5S007	YWHAE	Homo sapiens	P62258	Anti Tag CoIP	23075850
Intra	LRRK2	Q5S007	YWHAE	Homo sapiens	P62258	Anti Tag CoIP	31046837
Intra	LRRK2	Q5S007	YWHAE	Homo sapiens	P62258	TAP	24725412
Intra	LRRK2	Q5S007	YWHAE	Homo sapiens	P62258	Anti Tag CoIP	20642453
Intra	LRRK2	Q5S007	BAG5	Homo sapiens	Q9UL15	Protein Array	24510904
Intra	LRRK2	Q5S007	BAG5	Homo sapiens	Q9UL15	Anti Tag CoIP	24510904
Intra	LRRK2	Q5S007	BAG5	Homo sapiens	Q9UL15	Anti Tag CoIP	24947832
Intra	LRRK2	Q5S007	TUBB6	Homo sapiens	Q9BUF5	Anti Tag CoIP	31046837
Intra	LRRK2	Q5S007	RPL14	Homo sapiens	P50914	TAP	24725412
Intra	LRRK2	Q5S007	RPL14	Homo sapiens	P50914	Protein Kinase Assay	24725412
Intra	LRRK2	Q5S007	RPL13	Homo sapiens	P26373	TAP	24725412
Intra	LRRK2	Q5S007	RPL13	Homo sapiens	P26373	Anti Tag CoIP	31046837
Intra	LRRK2	Q5S007	RPL13	Homo sapiens	P26373	Protein Kinase Assay	24725412
Intra	LRRK2	Q5S007	RPL10A	Homo sapiens	P62906	Anti Tag CoIP	31046837
Intra	LRRK2	Q5S007	RPL10A	Homo sapiens	P62906	Protein Kinase Assay	24725412
Intra	LRRK2	Q5S007	RPL10A	Homo sapiens	P62906	TAP	24725412
Intra	LRRK2	Q5S007	STUB1	Homo sapiens	Q9UNE7	Protein Array	24510904
Intra	LRRK2	Q5S007	STUB1	Homo sapiens	Q9UNE7	Anti Tag CoIP	31046837
Intra	LRRK2	Q5S007	PPP1CA	Homo sapiens	P62136	Anti Bait CoIP	23937259
Intra	LRRK2	Q5S007	PPP1CA	Homo sapiens	P62136	PPase Assay	23937259
Intra	LRRK2	Q5S007	PPP1CA	Homo sapiens	P62136	Confocal	23937259
Intra	LRRK2	Q5S007	SEC16A	Homo sapiens	O15027	Confocal	25201882
Intra	LRRK2	Q5S007	SEC16A	Homo sapiens	O15027	Anti Tag CoIP	25201882
Intra	LRRK2	Q5S007	SEC16A	Homo sapiens	O15027	Anti Tag CoIP	31046837
Intra	LRRK2	Q5S007	LDHB	Homo sapiens	P07195	TAP	24725412
Intra	LRRK2	Q5S007	LDHB	Homo sapiens	P07195	Protein Kinase Assay	24725412
Intra	LRRK2	Q5S007	SLC25A4	Homo sapiens	P12235	TAP	24725412
Intra	LRRK2	Q5S007	YWHAB	Homo sapiens	P31946	Pull Down	20642453
Intra	LRRK2	Q5S007	YWHAB	Homo sapiens	P31946	Anti Tag CoIP	20642453
Intra	LRRK2	Q5S007	YWHAB	Homo sapiens	P31946	Protein Array	24510904
Intra	LRRK2	Q5S007	YWHAG	Homo sapiens	P61981	Anti Tag CoIP	23075850
Intra	LRRK2	Q5S007	YWHAG	Homo sapiens	P61981	ITC	28202711
Intra	LRRK2	Q5S007	YWHAG	Homo sapiens	P61981	Pull Down	20642453
Intra	LRRK2	Q5S007	YWHAG	Homo sapiens	P61981	FPS	28202711
Intra	LRRK2	Q5S007	YWHAG	Homo sapiens	P61981	Anti Tag CoIP	20642453
Intra	LRRK2	Q5S007	YWHAG	Homo sapiens	P61981	Anti Tag CoIP	24947832
Intra	LRRK2	Q5S007	YWHAQ	Homo sapiens	P27348	Anti Tag CoIP	24947832
Intra	LRRK2	Q5S007	YWHAQ	Homo sapiens	P27348	Anti Tag CoIP	23075850
Intra	LRRK2	Q5S007	YWHAQ	Homo sapiens	P27348	Anti Tag CoIP	31046837
Intra	LRRK2	Q5S007	YWHAQ	Homo sapiens	P27348	Pull Down	20642453
Intra	LRRK2	Q5S007	YWHAQ	Homo sapiens	P27348	Anti Tag CoIP	20642453
Intra	LRRK2	Q5S007	YWHAQ	Homo sapiens	P27348	SPR	24351927
Intra	LRRK2	Q5S007	MAPT	Homo sapiens	P10636-8	Protein Kinase Assay	24113872
Intra	LRRK2	Q5S007	MAPT	Homo sapiens	P10636-8	Pull Down	22303461
Intra	LRRK2	Q5S007	MAPT	Homo sapiens	P10636-8	Protein Kinase Assay	22303461
Intra	LRRK2	Q5S007	RPP25	Homo sapiens	Q9BUL9	Y2H Pooling	32814053
Intra	LRRK2	Q5S007	RPP25	Homo sapiens	Q9BUL9	Validated Y2H	32814053
Intra	LRRK2	Q5S007	RPP25	Homo sapiens	Q9BUL9	Y2H Array	32814053
Intra	LRRK2	Q5S007	RAB29	Homo sapiens	O14966	IF	24510904
Intra	LRRK2	Q5S007	RAB29	Homo sapiens	O14966	Protein Array	24510904
Intra	LRRK2	Q5S007	RAB29	Homo sapiens	O14966	Anti Tag CoIP	24510904
Intra	LRRK2	Q5S007	RPS15	Homo sapiens	P62841	Protein Kinase Assay	26824392
Intra	LRRK2	Q5S007	RPS15	Homo sapiens	P62841	Protein Kinase Assay	24725412
Intra	LRRK2	Q5S007	RPS15	Homo sapiens	P62841	Anti Bait CoIP	24725412
Intra	LRRK2	Q5S007	RPS15	Homo sapiens	P62841	Anti Tag CoIP	24725412
Intra	LRRK2	Q5S007	RPS15	Homo sapiens	P62841	Anti Tag CoIP	24947832
Intra	LRRK2	Q5S007	GSK3B	Homo sapiens	P49841	Pull Down	24165324
Intra	LRRK2	Q5S007	GSK3B	Homo sapiens	P49841	Anti Tag CoIP	24165324
Intra	LRRK2	Q5S007	NEK1	Homo sapiens	Q96PY6	Protein Array	24510904
Cross	LRRK2	Q5S007	Dnm1	Mus musculus	P39053	Pull Down	21307259
Cross	LRRK2	Q5S007	Dnm1	Mus musculus	P39053	Pull Down	24687852
Intra	LRRK2	Q5S007	RAB5B	Homo sapiens	P61020	Protein Kinase Assay	25605758
Intra	LRRK2	Q5S007	RAB5B	Homo sapiens	P61020	Confocal	18445495
Intra	LRRK2	Q5S007	RAB5B	Homo sapiens	P61020	Protein Kinase Assay	27314038
Intra	LRRK2	Q5S007	RAB5B	Homo sapiens	P61020	Y2H	18445495
Intra	LRRK2	Q5S007	RAC1	Homo sapiens	P63000	Anti Tag CoIP	21454543
Intra	LRRK2	Q5S007	BCL2	Homo sapiens	P10415-1	Protein Kinase Assay	25446991
Intra	LRRK2	Q5S007	RPS2	Homo sapiens	P15880	Protein Kinase Assay	24725412
Intra	LRRK2	Q5S007	RPS2	Homo sapiens	P15880	Anti Tag CoIP	31046837
Intra	LRRK2	Q5S007	RPS2	Homo sapiens	P15880	TAP	24725412
Intra	LRRK2	Q5S007	MAP2K6	Homo sapiens	P52564	Anti Tag CoIP	20067578
Intra	LRRK2	Q5S007	SFN	Homo sapiens	P31947	Anti Tag CoIP	31046837
Intra	LRRK2	Q5S007	SFN	Homo sapiens	P31947	X-Ray Diffraction	28202711
Intra	LRRK2	Q5S007	SFN	Homo sapiens	P31947	Protein Array	24510904
Intra	LRRK2	Q5S007	PRKACA	Homo sapiens	P17612	Protein Kinase Assay	24351927
Intra	LRRK2	Q5S007	MAP2K7	Homo sapiens	O14733	Anti Tag CoIP	20067578
Intra	LRRK2	Q5S007	FADD	Homo sapiens	Q13158	Anti Tag CoIP	19176810
Intra	LRRK2	Q5S007	AGO2	Homo sapiens	Q9UKV8	Anti Bait CoIP	20671708
Intra	LRRK2	Q5S007	AGO2	Homo sapiens	Q9UKV8	Anti Tag CoIP	17400507
Intra	LRRK2	Q5S007	MSN	Homo sapiens	P26038	Protein Kinase Assay	22363216
Intra	LRRK2	Q5S007	MSN	Homo sapiens	P26038	Protein Kinase Assay	22952686
Intra	LRRK2	Q5S007	MSN	Homo sapiens	P26038	Anti Tag CoIP	31046837
Intra	LRRK2	Q5S007	MSN	Homo sapiens	P26038	Protein Kinase Assay	25009464
Intra	LRRK2	Q5S007	MSN	Homo sapiens	P26038	Protein Kinase Assay	24695735
Intra	LRRK2	Q5S007	MSN	Homo sapiens	P26038	Protein Kinase Assay	20642453
Intra	LRRK2	Q5S007	MSN	Homo sapiens	P26038	Protein Kinase Assay	26824392
Intra	LRRK2	Q5S007	MSN	Homo sapiens	P26038	Protein Kinase Assay	24904275
Intra	LRRK2	Q5S007	MSN	Homo sapiens	P26038	Protein Kinase Assay	27357661
Intra	LRRK2	Q5S007	CUEDC1	Homo sapiens	Q9NWM3	Protein Array	24510904
Intra	LRRK2	Q5S007	MAP2K3	Homo sapiens	P46734	Anti Tag CoIP	20067578
Intra	LRRK2	Q5S007	MAP2K3	Homo sapiens	P46734	CoIP	20173330
Intra	LRRK2	Q5S007	ARFGAP1	Homo sapiens	Q8N6T3-2	Protein Kinase Assay	22363216
Intra	LRRK2	Q5S007	ARFGAP1	Homo sapiens	Q8N6T3-2	Anti Tag CoIP	22363216
Intra	LRRK2	Q5S007	DVL1	Homo sapiens	O14640-2	Anti Tag CoIP	19625296
Intra	LRRK2	Q5S007	DVL1	Homo sapiens	O14640-2	Confocal	19625296
Intra	LRRK2	Q5S007	DVL1	Homo sapiens	O14640-2	Y2H	19625296
Cross	LRRK2	Q5S007	Spag9	Mus musculus	Q58A65	CoIP	20173330
Intra	LRRK2	Q5S007	RAB38	Homo sapiens	P57729	Pull Down	31552791
Intra	LRRK2	Q5S007	SH3GL1	Homo sapiens	Q99961	Anti Tag CoIP	31046837
Intra	LRRK2	Q5S007	SH3GL1	Homo sapiens	Q99961	Protein Kinase Assay	22998870
Intra	LRRK2	Q5S007	SPATA22	Homo sapiens	Q8NHS9	Y2H Array	32814053
Intra	LRRK2	Q5S007	SPATA22	Homo sapiens	Q8NHS9	Y2H Pooling	32814053
Intra	LRRK2	Q5S007	SPATA22	Homo sapiens	Q8NHS9	Validated Y2H	32814053
Intra	LRRK2	Q5S007	TUBB2A	Homo sapiens	Q13885	Y2H	24275654
Intra	LRRK2	Q5S007	TUBB2A	Homo sapiens	Q13885	Anti Tag CoIP	31046837
Intra	LRRK2	Q5S007	RGS2	Homo sapiens	P41220	Anti Tag CoIP	24794857
Intra	LRRK2	Q5S007	RGS2	Homo sapiens	P41220	Confocal	24794857
Intra	LRRK2	Q5S007	RGS2	Homo sapiens	P41220	Protein Kinase Assay	24794857
Intra	LRRK2	Q5S007	CHGB	Homo sapiens	P05060	Protein Array	24510904
Intra	LRRK2	Q5S007	DNM1	Homo sapiens	Q05193	Confocal	24282027
Intra	LRRK2	Q5S007	DNM1	Homo sapiens	Q05193	Y2H	24282027
Intra	LRRK2	Q5S007	DNM1	Homo sapiens	Q05193	Anti Tag CoIP	24282027
Intra	LRRK2	Q5S007	GAK	Homo sapiens	O14976	IF	24510904
Intra	LRRK2	Q5S007	GAK	Homo sapiens	O14976	Confocal	24510904
Intra	LRRK2	Q5S007	GAK	Homo sapiens	O14976	Protein Array	24510904
Intra	LRRK2	Q5S007	NFATC2	Homo sapiens	Q13469	Anti Bait CoIP	21983832
Intra	LRRK2	Q5S007	PPP1R8	Homo sapiens	Q12972	Anti Tag CoIP	31046837
Intra	LRRK2	Q5S007	PPP1R8	Homo sapiens	Q12972	Protein Array	24510904
Intra	LRRK2	Q5S007	ARHGEF7	Homo sapiens	Q14155	Anti Tag CoIP	25500533
Intra	LRRK2	Q5S007	ARHGEF7	Homo sapiens	Q14155	Anti Tag CoIP	21048939
Intra	LRRK2	Q5S007	ARHGEF7	Homo sapiens	Q14155	GTPase Assay	21048939
Intra	LRRK2	Q5S007	ECHS1	Homo sapiens	P30084	Protein Array	24510904
Intra	LRRK2	Q5S007	ECHS1	Homo sapiens	P30084	Anti Tag CoIP	31046837
Intra	LRRK2	Q5S007	RAB8A	Homo sapiens	P61006	Anti Tag CoIP	31046837
Intra	LRRK2	Q5S007	RAB8A	Homo sapiens	P61006	Anti Tag CoIP	26824392
Intra	LRRK2	Q5S007	RAB8A	Homo sapiens	P61006	Protein Kinase Assay	26824392
Intra	LRRK2	Q5S007	RAB8A	Homo sapiens	P61006	Protein Kinase Assay	32227113
Intra	LRRK2	Q5S007	DNM1L	Homo sapiens	O00429	Anti Bait CoIP	22228096
Intra	LRRK2	Q5S007	DNM1L	Homo sapiens	O00429	Anti Tag CoIP	31046837
Intra	LRRK2	Q5S007	DNM1L	Homo sapiens	O00429	Anti Tag CoIP	29541021
Intra	LRRK2	Q5S007	DNM1L	Homo sapiens	O00429	Pull Down	29541021
Intra	LRRK2	Q5S007	DNM1L	Homo sapiens	O00429	Confocal	22639965
Intra	LRRK2	Q5S007	RAB10	Homo sapiens	P61026	Anti Tag CoIP	31046837
Intra	LRRK2	Q5S007	RAB10	Homo sapiens	P61026	Protein Kinase Assay	26824392
Intra	LRRK2	Q5S007	DVL3	Homo sapiens	Q92997	Anti Tag CoIP	19625296
Intra	LRRK2	Q5S007	DVL3	Homo sapiens	Q92997	Confocal	19625296
Intra	LRRK2	Q5S007	DVL2	Homo sapiens	O14641	Anti Tag CoIP	31046837
Intra	LRRK2	Q5S007	DVL2	Homo sapiens	O14641	Y2H	19625296
Intra	LRRK2	Q5S007	TCF25	Homo sapiens	Q9BQ70	Anti Tag CoIP	31046837
Intra	LRRK2	Q5S007	BAG3	Homo sapiens	O95817	Protein Array	24510904
Intra	LRRK2	Q5S007	PRDX3	Homo sapiens	P30048	Anti Tag CoIP	24459295
Intra	LRRK2	Q5S007	PRDX3	Homo sapiens	P30048	Anti Tag CoIP	31046837
Intra	LRRK2	Q5S007	PRDX3	Homo sapiens	P30048	Confocal	21850687
Intra	LRRK2	Q5S007	PRDX3	Homo sapiens	P30048	Protein Kinase Assay	21850687
Intra	LRRK2	Q5S007	PRDX3	Homo sapiens	P30048	Anti Tag CoIP	21850687
Intra	LRRK2	Q5S007	PRDX3	Homo sapiens	P30048	Y2H	21850687
Intra	LRRK2	Q5S007	PRDX3	Homo sapiens	P30048	Anti Bait CoIP	21850687
Intra	LRRK2	Q5S007	MATK	Homo sapiens	P42679	Protein Array	24510904
Cross	LRRK2	Q5S007	Atp2a2	Mus musculus	O55143	Anti Bait CoIP	31046837
Cross	LRRK2	Q5S007	Stub1	Mus musculus	Q9WUD1	Anti Tag CoIP	19196961
Cross	LRRK2	Q5S007	Ckmt1	Mus musculus	P30275	Anti Tag CoIP	21370995
Cross	LRRK2	Q5S007	Ckmt1	Mus musculus	P30275	Pull Down	21370995
Intra	LRRK2	Q5S007	SH3GL2	Homo sapiens	Q99962	Protein Kinase Assay	22998870
Intra	LRRK2	Q5S007	SH3GL2	Homo sapiens	Q99962	Protein Kinase Assay	25501810
Intra	LRRK2	Q5S007	MAPT	Homo sapiens	P10636-2	Protein Kinase Assay	24113872
Intra	LRRK2	Q5S007	CDC42	Homo sapiens	P60953	Anti Tag CoIP	21048939
Intra	LRRK2	Q5S007	CDC42	Homo sapiens	P60953	Confocal	21048939
Cross	LRRK2	Q5S007	Rab5b	Mus musculus	P61021	Pull Down	18445495
Cross	LRRK2	Q5S007	Mfn1	Mus musculus	Q811U4	Anti Tag CoIP	24282027
Intra	LRRK2	Q5S007	LRP6	Homo sapiens	O75581	Anti Tag CoIP	22899650
Intra	LRRK2	Q5S007	LRP6	Homo sapiens	O75581	Y2H	22899650
Intra	LRRK2	Q5S007	LRP6	Homo sapiens	O75581	Y2H	27013965
Intra	LRRK2	Q5S007	P46821-PRO_0000018605	Homo sapiens	P46821-PRO_0000018605	Protein Kinase Assay	24754922
Intra	LRRK2	Q5S007	P46821-PRO_0000018605	Homo sapiens	P46821-PRO_0000018605	Pull Down	24754922
Intra	LRRK2	Q5S007	RAB32	Homo sapiens	Q13637	Anti Tag CoIP	25360523
Intra	LRRK2	Q5S007	RAB32	Homo sapiens	Q13637	IF	25360523
Intra	LRRK2	Q5S007	SNCA	Homo sapiens	P37840	Anti Bait CoIP	23183827
Intra	LRRK2	Q5S007	SNCA	Homo sapiens	P37840	Confocal	23183827
Intra	LRRK2	Q5S007	SNCA	Homo sapiens	P37840	Anti Tag CoIP	23183827
Cross	LRRK2	Q5S007	Ywhag	Rattus norvegicus	P61983	Far-WB	24351927
Cross	LRRK2	Q5S007	Ywhag	Rattus norvegicus	P61983	FPS	24351927
Cross	LRRK2	Q5S007	Ywhag	Rattus norvegicus	P61983	SPR	24351927
Cross	LRRK2	Q5S007	Arfgap1	Rattus norvegicus	Q62848	Confocal	22363216
Cross	LRRK2	Q5S007	Arfgap1	Rattus norvegicus	Q62848	Comigration in SDS	22363216
Cross	LRRK2	Q5S007	Arfgap1	Rattus norvegicus	Q62848	Anti Tag CoIP	22363216
Cross	LRRK2	Q5S007	Arfgap1	Rattus norvegicus	Q62848	GTPase Assay	22363216
Cross	LRRK2	Q5S007	phoA	Escherichia coli	P00634	PPase Assay	23937259
Cross	LRRK2	Q5S007	Prkar2b	Rattus norvegicus	P12369	Anti Tag CoIP	24464040
Cross	LRRK2	Q5S007	Rab29	Rattus norvegicus	Q63481	Confocal	23395371
Cross	LRRK2	Q5S007	MBP	Bos taurus	P02687	Protein Kinase Assay	21658387

Cross: Cross-species interaction Intra: Intraspecies interaction

LRRK2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P810542	Phospho-LRRK2 (Ser935) Antibody (YA9811)	WB, ICC/IF, FC	Human, Mouse
HY-P83076	LRRK2 Antibody (YA2821)	WB, IHC-P, ICC/IF	Human, Mouse
HY-P83076A	Phospho-LRRK2(Ser935) Antibody (YA3424)	WB, ICC/IF	Human, Mouse
HY-P84632	LRRK2 Antibody (YA4329)	ICC/IF, FC, ELISA	Human
HY-P84632A	LRRK2 Antibody (YA4329)(PBS only)	ICC/IF, FC, ELISA	Human
HY-P84633	LRRK2 Antibody (YA4330)	IHC-P, FC, ELISA	Human
HY-P84633A	LRRK2 Antibody (YA4330)(PBS only)	IHC-P, FC, ELISA	Human

Related Diseases

Diseases	Alias
Postencephalitic Parkinson Disease	Postencephalitic Parkinsonism Parkinson Disease, Postencephalitic
Machado-Joseph Disease	SCA3 MJD Spinocerebellar Ataxia 3 Azorean Disease Spinocerebellar Ataxia Type 3 Azorean Neurologic Disease Spinopontine Atrophy Nigrospinodentatal Degeneration Spinocerebellar Atrophy Spinocerebellar Atrophy Iii Spinocerebellar Atrophy Type 3 Azorean Ataxia Azorean Disease Of The Nervous System Machado Disease Nigro-Spino-Dentatal Degeneration With Nuclear Ophthalmoplegia Disease, Machado-Joseph Ataxia, Spinocerebellar
Athetosis
Charcot-Marie-Tooth Disease	Cmt Hmsn Hereditary Motor And Sensory Neuropathy Pma Cmt - Charcot-Marie-Tooth Disease Charcot Marie Tooth Disease Charcot-Marie-Tooth Hereditary Neuropathy Charcot-Marie-Tooth Syndrome Peroneal Muscular Atrophy Hereditary Motor And Sensory Neuropathies
Peripheral Nervous System Disease	Peripheral Neuropathy Peripheral Nerve Disease Peripheral Nerve Disorders Neuropathy, Peripheral Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation
Aphasia
Dementia	Dementias Presenile Dementia Alzheimer Type Dementia Alzheimer Sclerosis Alzheimer Disease Dementia Alzheimer Dementia Primary Degenerative Alzheimer Type Dementia End Stage Alzheimer'S Dementia Alzheimer'S Type Atypical Dementia Alzheimer Type Presenile Dementia Early Onset Alzheimer Dementia Dementia In Alzheimer Disease Type 2 Dementia In Alzheimer Disease With Early Onset Early Onset Alzheimer Type Dementia, Uncomplicated Primary Degenerative Alzheimer Type Dementia, Early Onset Primary Degenerative Alzheimer Type Dementia, Presenile Onset, Uncomplicated Alzheimer Disease Dementia With Early Onset Presenile Sclerosis Presenile Brain Sclerosis Presenile Alzheimer Brain Sclerosis Late Onset Alzheimer Dementia Dementia In Alzheimer Disease Type 1 Dementia In Alzheimer Disease With Late Onset Primary Degenerative Alzheimer Type Dementia, Late Onset Sdat - [Senile Dementia, Alzheimer Type] Alzheimer Disease Dementia With Late Onset Late Onset Alzheimer Brain Sclerosis Senile Alzheimer Brain Disease Senile Alzheimer Brain Sclerosis Senile Primary Degenerative Alzheimer Type Dementia Senile Dementia Of The Alzheimer Type Arteriosclerotic Dementia Strategic-Infarct Dementia Post Stroke Dementia Vascular Cognitive Impairment Vascular Dementia Dementia Of The Lewy Body Type Dementia With Lewy Bodies Sdlt - [Senile Dementia Of The Lewy Body Type] Senile Dementia Of The Lewy Body Type Alcohol-Related Dementia Alcoholic Dementia Nos Alcohol-Induced Dementia Alcoholic Brain Syndrome Chronic Alcoholic Brain Syndrome Alcohol Dementia Late Onset Alcoholic Psychosis Residual And Late-Onset Alcohol-Induced Psychotic Disorder Mental And Behavioural Disorders Due To Use Of Sedatives Or Hypnotics, Residual And Late-Onset Psychotic Disorder Late-Onset Psychoactive Substance-Induced Psychotic Disorder Inhalant Dementia Volatile Solvents Dementia Dementia In Paralysis Agitans Pdd - [Parkinson Disease Dementia] Dementia Syndrome Of Parkinson Disease Dementia In Parkinson Disease Parkinson Related Dementia Dementia In Huntington Chorea Hiv - [Human Immunodeficiency Virus] Dementia Hiv- [Human Immunodeficiency Virus] Associated Cognitive Motor Complex Hiv- [Human Immunodeficiency Virus] Associated Dementia Complex Aids - [Acquired Immunodeficiency Syndrome] Dementia Complex Aids Related Dementia Dementia Due To Niacin Deficiency
Rem Sleep Behavior Disorder	Rem Sleep Behaviour Disorder Rapid Eye Movement Sleep Behavior Disorder Rapid Eye Movement Sleep Behaviour Disorder Rem - [Rapid Eye Movement] Behaviour Disorder
Frontotemporal Dementia	Pallidopontonigral Degeneration Frontotemporal Lobar Degeneration Semantic Dementia FTD Frontotemporal Lobe Dementia Multiple System Tauopathy With Presenile Dementia Dementia, Frontotemporal Frontotemporal Dementia With Parkinsonism Mstd Frontotemporal Lobar Degeneration With Tau Inclusions Ftld With Tau Inclusions Dementia, Frontotemporal, With Parkinsonism Fldem Ftdp17 Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex Ddpac Wilhelmsen-Lynch Disease Wld Ppnd Dementia, Frontotemporal, With Or Without Parkinsonism Semantic Primary Progressive Aphasia Semantic Variant Ppa Wilhemsen-Lynch Disease Frontotemporal Dementia-Amyotrophic Lateral Sclerosis Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17 Ftd-Als Ftld Pick Complex Pick Disease Of The Brain Frontotemporal Dementia With Parkinsonism-17 Grn-Related Frontotemporal Dementia Frontotemporal Dementia With Motor Neuron Disease Dementia In Fronto-Temporal Lobar Degeneration Ftd - [Frontotemporal Dementia] Temple Dementia Frontal Lobe Dementia
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Neuronal Ceroid Lipofuscinosis	Hereditary Ceroid Lipofuscinosis Batten Disease Ncl Neuronal Ceroid-Lipofuscinoses Lipofuscinosis, Ceroid, Neuronal Juvenile Neuronal Ceroid Lipofuscinosis Cerebromacular Dystrophy Cerebromacular Degeneration Ceroid-Lipofuscinosis Ncl - [Neuronal Ceroid Lipofuscinosis] Amaurotic Familial Idiocy Amaurotic Idiocy Amaurotic Idiot Neuronal Lipofuscinosis Pigmentary Retinal Lipoid Neuronal Heredodegeneration
Constipation
Kufor-Rakeb Syndrome	Park9 Krppd KRS Pallidopyramidal Degeneration With Supranuclear Upgaze Paresis And Dementia Autosomal Recessive Parkinson Disease 9 Parkinson Disease 9 Parkinson Disease 9, Autosomal Recessive, Juvenile-Onset Autosomal Recessive Juvenile Onset Parkinson Disease 9 Parkinson Disease Type 9 Pallidopyramidal Degeneration With Supranuclear Upgaze Paresis, And Dementia Park 9 Atp13a2-Related Juvenile Neuronal Ceroid Lipofuscinosis Cln12 Disease Juvenile Parkinsonism-Neuronal Ceroid Lipofuscinosis Parkinson Disease Autosomal Recessive 9
Klippel-Feil Syndrome 1, Autosomal Dominant	KFS1 Cervical Vertebral Fusion Autosomal Dominant Kfs Cervical Vertebral Fusion, Autosomal Dominant Cervical Vertebral Fusion Congenital Congenital Klippel-Feil Segment Fused Cervical Segments Congenital Isolated Klippel-Feil Syndrome Klippel-Feil Malformation Klippel-Feil Sequence Klippel-Feil Syndrome, Type 1, Autosomal Dominant Klippel-Feil Syndrome, Autosomal Dominant
Sleep Disorder	Sleep Disorders Non-Organic Sleep Disorder
Meier-Gorlin Syndrome 3	MGORS3 Meier-Gorlin Syndrome, Type 3
Hereditary Late-Onset Parkinson Disease	Autosomal Dominant Late-Onset Parkinson Disease Lopd Hereditary Late Onset Parkinson Disease
Parkinson Disease 15, Autosomal Recessive Early-Onset	Parkinsonian-Pyramidal Syndrome Pallidopyramidal Syndrome Parkinson Disease 15, Autosomal Recessive PARK15 Pkps Pallido-Pyramidal Syndrome Parkinson'S Disease 15 Autosomal Recessive Early-Onset Parkinson Disease 15 Autosomal Recessive Early-Onset Parkinson'S Disease 15 Pallido-Pyramidal Disease Parkinson Disease 15 Parkinson Disease 15 Autosomal Recessive Pps Parkinson Disease, Type 15
Intellectual Developmental Disorder, Autosomal Dominant 55, With Seizures	MRD55 Mental Retardation, Autosomal Dominant 55, With Seizures Autosomal Dominant Mental Retardation 55 Autosomal Dominant Intellectual Developmental Disorder 55 Autosomal Dominant Intellectual Developmental Disorder-55 With Seizures Mental Retardation, Autosomal Dominant, Type 55, With Seizures
Hereditary Spastic Paraplegia	Familial Spastic Paraplegia Hereditary Spastic Paraparesis Strumpell-Lorrain Disease Hsp Spg Strümpell-Lorrain Disease Spastic Paraplegia, Hereditary French Settlement Disease Strumpell-Lorrain Syndrome Fsp Familial Spastic Paraparesis Spastic Paraplegia, Familial Spastic Paraplegia Hereditary Spastic Paraplegia 3, Autosomal Dominant Spastic Paraparesis Hereditary Spastic Paralysis Familial Spastic Paralysis Hereditary Spastic Ataxia
Rheumatoid Arthritis	RA Arthritis, Rheumatoid Rheumatoid Arthritis, Susceptibility To Arthritis Or Polyarthritis, Rheumatic Atrophic Arthritis Rheumatism Arthritis Rheumatoid Polyarthritis
Multiple System Atrophy 1	Multiple System Atrophy Shy-Drager Syndrome Msa MSA1 Multiple System Atrophy 1, Susceptibility To Sporadic Olivopontocerebellar Atrophy Multisystem Atrophy Msa1, Susceptibility To Multiple System Atrophy, Susceptibility To Opca Progressive Autonomic Failure With Multiple System Atrophy Sds
Parkinson Disease 1, Autosomal Dominant	Autosomal Dominant Parkinson Disease 1 PARK1 Parkinson Disease 1 Parkinson'S Disease 1 Atypical Parkinson Disease Parkinson Disease 1, Autosomal Dominant Lewy Body Autosomal Dominant Parkinson'S Disease 1 Lewy Body Parkinsonism Parkinson Disease Autosomal Dominant 1 Parkinson Disease Familial Type 1 Parkinson Disease, Type 1 Parkinson Disease, Familial, Type 1
Ciliary Dyskinesia, Primary, 43	CILD43 Primary Ciliary Dyskinesia 43 Ciliary Dyskinesia, Primary, 43, With Or Without Situs Inversus Primary Ciliary Dyskinesia 43 With Or Without Situs Inversus Ciliary Dyskinesia, Primary, 43 With Or Without Situs Inversus
Movement Disease	Movement Disorders Movement Disorder
Early-Onset Parkinson'S Disease	Early-Onset Parkinson Disease
Parkinson Disease 2, Autosomal Recessive Juvenile	Young-Onset Parkinson Disease PARK2 Pdj Autosomal Recessive Juvenile Parkinson Disease 2 Epdf Parkinson Disease, Juvenile, Type 2 Parkinson'S Disease 2 Autosomal Recessive Juvenile Parkinson Disease Early-Onset Parkinson Disease Parkinson Disease 2 Parkinson Disease, Juvenile, Autosomal Recessive Parkinsonism, Early-Onset, With Diurnal Fluctuation Autosomal Recessive Juvenile Parkinson'S Disease 2 Jp Juvenile Parkinsonism Parkinson Disease Autosomal Recessive, Early Onset Parkinsonism, Early Onset, With Diurnal Fluctuation Yopd Autosomal Recessive Early-Onset Parkinson Disease Type 2 Chromosome 6-Linked Autosomal Recessive Parkinsonism Early-Onset Parkinsonism With Diurnal Fluctuation Parkinsonism Young Adult Onset Parkinson Disease, Type 2 Parkinsonism, Juvenile
Vascular Parkinsonism
Dementia, Lewy Body	Lewy Body Dementia Lewy Body Disease Diffuse Lewy Body Disease Dementia With Lewy Bodies DLB Autosomal Dominant Diffuse Lewy Body Disease Cortical Lewy Body Disease Dementia, Lewy Body, Susceptibility To Lewy Body Dementia, Susceptibility To Senile Dementia Of The Lewy Body Type Dementia Of The Lewy Body Type Lbd Diffuse Lewy Body Disease With Gaze Palsy Dysphasic Dementia Hereditary Lewy Body Type Senile Dementia Lewy Body Variant Of Alzheimer Disease Lewy Bodies Lewy Body Dlbd - [Diffuse Lewy Body Disease] Clbd - [Cortical Lewy Body Disease]
3-Methylglutaconic Aciduria, Type Iii	Optic Atrophy 3-Methylglutaconic Aciduria Type 3 Costeff Syndrome Mga3 Costeff Optic Atrophy Syndrome Optic Atrophy Plus Syndrome Infantile Optic Atrophy With Chorea And Spastic Paraplegia 3-Methylglutaconic Aciduria Type Iii Autosomal Recessive Optic Atrophy Plus Syndrome Autosomal Recessive Optic Atrophy Type 3 Opa3 Defect MGCA3 Mga, Type Iii Iraqi Jewish Optic Atrophy Plus Mga Type Iii Optic Atrophy, Infantile, With Chorea And Spastic Paraplegia Iraqi-Jewish 'Optic Atrophy Plus' Optic Atrophy 3, Autosomal Recessive Opa3, Autosomal Recessive Opa3-Related 3-Methylglutaconic Aciduria Iraqi-Jewish Optic Atrophy Plus Atrophy Of Optic Disc 3-Alpha Methylglutaconic Aciduria Type Iii Optic Atrophy 3 Optic Atrophy Infantile With Chorea And Spastic Paraplegia Autosomal Recessive Opa3 Autosomal Recessive Optic Atrophy 3 3-Methylglutaconic Aciduria 3 3-Alpha-Methylglutaconic Aciduria Type 3 Optic Atrophy 3 Autosomal Recessive Atrophy, Optic Atrophy, Optic, Plus Syndrome Optic Nerve Atrophy Primary Optic Atrophy Oa - [Optic Atrophy] Second Cranial Nerve Atrophy Second Cranium Nerve Atrophy
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease
Parkinson Disease 3, Autosomal Dominant	Parkinson Disease 3 PARK3 Parkinson Disease 3, Autosomal Dominant Lewy Body Parkinson'S Disease 3 Autosomal Dominant Lewy Body Parkinson Disease 3 Autosomal Dominant Parkinson Disease 3 Parkinson Disease Type 3 Autosomal Dominant Parkinson Disease Parkinson Disease, Autosomal Dominant Parkinson Disease, Familial, Type 1
Choreatic Disease	Chorea Hereditary Chorea
Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex 1	Guam Disease Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex Of Guam Als-Pdc Lytico-Bodig Disease Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex 1, Susceptibility To Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex, Susceptibility To Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Of Guam Syndrome Parkinsonism-Dementia-Als Complex Pdals Amyotrophic Lateral Sclerosis, Parkinsonism/Dementia Complex Of Guam Parkinson-Dementia Complex Of Guam G-Pdc Guam Parkinsonism-Dementia Complex ALS-PDC1 Als/Pdc Of Guam Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic/Parkinsonism/Dementia Complex 1 Amyotrophic Lateral Sclerosis, Guam Form Parkinsonian Disorders
Parkinson Disease 8, Autosomal Dominant	Parkinson Disease 8 Autosomal Dominant Parkinson Disease 8 PARK8 Parkinson'S Disease 8 Autosomal Dominant Parkinson'S Disease 8 Parkinson Disease-8 Parkinson Disease, Type 8, Autosomal Dominant
Pick Disease Of Brain	Pick Disease Pick Disease Of The Brain Lobar Atrophy Of Brain Dementia With Lobar Atrophy And Neuronal Cytoplasmic Inclusions Pick'S Disease Behavioral Variant Of Frontotemporal Dementia Dementia In Pick'S Disease Lobar Atrophy Of The Brain Bvftd Bv-Ftd PIDB Picks Disease
Parkinsonism	Parkinsonism-Plus Idiopathic Parkinsonism Primary Parkinsonism Paralysis Agitans Syndrome Parkinsonian Syndrome Trembling Paralysis Paralysis Agitans Shaking Palsy Shaking Paralysis
Cerebellar Disease	Cerebellar Diseases Cerebellar Dysfunction Cerebellar Abnormality Cerebellar Disorders
Gerstmann-Straussler Disease	Gerstmann-Straussler-Scheinker Disease Gerstmann-Straussler-Scheinker Syndrome Prion Dementia Cerebral Amyloid Angiopathy, Prnp-Related GSD Gss Cerebellar Ataxia, Progressive Dementia, And Amyloid Deposits In Cns Amyloidosis, Cerebral, With Spongiform Encephalopathy Subacute Spongiform Encephalopathy, Gerstmann-Straussler Type Encephalopathy, Subacute Spongiform, Gerstmann-Straussler Type Amyloidosis Cerebral With Spongiform Encephalopathy Cerebellar Ataxia, Progressive Dementia, And Amyloid Deposits In The Central Nervous System Encephalopathy Subacute Spongiform Gerstmann-Straussler Type Gssd Gerstmann Straussler Scheinker Syndrome Cerebral Amyloidosis With Spongiform Encephalopathy Subacute Spongiform Encephalopathy Gerstmann-Straussler Type Gluthathione Synthetase Deficiency Gerstmann Straussler Syndrome
Creutzfeldt-Jakob Disease	Variant Creutzfeldt-Jakob Disease CJD Bovine Spongiform Encephalopathy Vcjd Inherited Creutzfeldt-Jakob Disease Creutzfeldt-Jakob Disease, Familial Creutzfeldt Jakob Disease Creutzfeldt-Jacob Disease Creutzfeldt Jacob Disease Sporadic Creutzfeldt-Jakob Disease Encephalopathy, Bovine Spongiform Creutzfeldt-Jakob Disease, Variant, Resistance To Creutzfeldt-Jakob Disease, Variant Creutzfeldt Jacob Syndrome Jakob-Creutzfeldt Disease Subacute Spongiform Encephalopathy Transmissible Virus Dementia New Variant Of Cjd Nv-Cjd Variant Cjd Variant Creutzfeldt-Jacob Disease Sporadic Cjd Inherited Cjd Acquired Creutzfeldt-Jakob Disease Variant Mcj Encephalopathy Bovine Spongiform Familial Creutzfeldt-Jakob Disease Creutzfeldt-Jakob Syndrome New Variant Creutzfeldt-Jakob Disease Creutzfeldt-Jakob Disease, Sporadic Acquired Cjd Scjd - [Sporadic Creutzfeldt-Jakob Disease] Idiopathic Creutzfeldt-Jakob Disease Creutzfeld-Jakob Disease Nos Vcjd - [Variant Creutzfeldt-Jakob Disease]
Gaucher'S Disease	Gaucher Disease Kerasin Thesaurismosis Glucocerebrosidase Deficiency Glucosylceramidase Deficiency Acid Beta-Glucosidase Deficiency Glucosylceramide Beta-Glucosidase Deficiency Acute Cerebral Gaucher Disease Cerebroside Lipidosis Syndrome Gaucher Splenomegaly Glucocerebrosidosis Glucosyl Cerebroside Lipidosis Kerasin Lipoidosis Lipoid Histiocytosis Glocucerebrosidase Deficiency Sphingolipidosis 1 Gaucher Syndrome Gauchers Disease Gd Glucosylceramide Lipidosis Kerasin Histiocytosis Gaucher Disease, Type 1 Gaucher Disease, Type 2
Tremor	Medicament-Induced Tremor Medication-Induced Postural Tremor
Mitochondrial Complex I Deficiency, Nuclear Type 1	Mitochondrial Complex I Deficiency Nadh:Q(1) Oxidoreductase Deficiency MC1DN1 Nadh-Coenzyme Q Reductase Deficiency Isolated Mitochondrial Respiratory Chain Complex I Deficiency Isolated Nadh-Coenzyme Q Reductase Deficiency Isolated Nadh-Coq Reductase Deficiency Isolated Nadh-Ubiquinone Reductase Deficiency Mitochondrial Nadh Dehydrogenase Component Of Complex I, Deficiency Of Nuclear Type Mitochondrial Complex I Deficiency 1 Isolated Complex I Deficiency Complex 1 Mitochondrial Respiratory Chain Deficiency Nadh Coenzyme Q Reductase Deficiency Complex I Mitochondrial Respiratory Chain Deficiency Deficiency Of Mitochondrial Nadh Dehydrogenase Component Of Complex I Nadh:Ubiquinone Oxidoreductase Deficiency Complex I, Mitochondrial Respiratory Chain, Deficiency Of
Autosomal Dominant Cerebellar Ataxia	Spinocerebellar Ataxia Adca Pierre Marie Cerebellar Ataxia Ataxia, Spinocerebellar Sca Autosomal Dominant Spinocerebellar Ataxia Spinocerebellar Ataxias
Von Economo'S Disease	Encephalitis Lethargica Von Economo Encephalitis Von Economo Disease
Supranuclear Palsy, Progressive, 1	Progressive Supranuclear Palsy Steele-Richardson-Olszewski Syndrome Supranuclear Palsy, Progressive Psp Progressive Supranuclear Ophthalmoplegia PSNP1 Familial Progressive Supranuclear Palsy Richardson'S Syndrome Psp Syndrome Progressive Supranuclear Palsy 1 Supranuclear Palsy Progressive Ophthalmoplegia, Supranuclear, Progressive Steele-Richardson-Olszewksi Syndrome
Essential Tremor	Benign Essential Tremor Familial Tremor Hereditary Essential Tremor Essential Hereditary Tremor Shaky Hand Syndrome Benign Essential Tremor Syndrome Tremor Hereditary Essential Essential Tremor, Susceptibility To Tremor, Hereditary Essential
Gaucher Disease, Type I	Glucocerebrosidase Deficiency Acid Beta-Glucosidase Deficiency Gba Deficiency GD1 Gd I Gaucher Disease, Noncerebral Juvenile Gaucher Disease Type 1 Gaucher Disease Type I Gaucher'S Disease Type I Gaucher Disease Gd 1 Non-Cerebral Juvenile Gaucher Disease GD Gaucher Disease 1 Adult Non-Neuronopathic Gaucher Disease Noncerebral Juvenile Gaucher Disease Type 1 Gaucher Disease Gaucher Disease, Type 1
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis
Striatonigral Degeneration
Toxic Encephalopathy	Neurotoxicity Neurotoxicity Syndromes Neurotoxicity Syndrome Encephalopathy, Toxic
Leprosy 3	Leprosy Leprosy, Susceptibility To, 3 Hansen'S Disease Leprosy, Susceptibility To Hansen Disease Infection Due To Mycobacterium Leprae LPRS3 Leprosy, Type 3 Anaesthesia Leprosy Anaesthetic Leprosy Maculoanaesthetic Leprosy Macular Leprosy Leprosy Unspecified
Sphingolipidosis	Sphingolipidoses

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-112809	GSK2646264	Inhibitor	99.74%	Phase 1

Pre-clinical Phase

Bioactive Molecules (65)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100411	MLi-2	Inhibitor	99.80%	Unkown
HY-13687	IKK 16	Inhibitor	99.88%	Unkown
HY-10875	LRRK2-IN-1	Inhibitor	99.04%	Unkown
HY-148030	XL01126	Inhibitor	98.90%	Unkown
HY-40294	Indazole	Inhibitor	99.83%	Unkown
HY-12477	PF-06447475	Inhibitor	99.94%	Unkown
HY-15796	GNE0877	Inhibitor	99.81%	Unkown
HY-13237	GSK2578215A	Inhibitor	99.82%	Unkown
HY-18163	GNE-7915	Inhibitor	99.81%	Unkown
HY-13687A	IKK 16 hydrochloride	Inhibitor	99.95%	Unkown
HY-13488	HG-10-102-01	Inhibitor	99.55%	Unkown
HY-120085	PFE-360	Inhibitor	99.10%	Unkown
HY-P5979	LRRKtide	Substrate	99.94%	Unkown
HY-15800A	CZC-25146	Inhibitor	99.10%	Unkown
HY-12282	GNE-9605	Inhibitor	99.51%	Unkown
HY-155150	JH-XII-03-02	Degrader	99.33%	Unkown
HY-111493	LRRK2 inhibitor 1	Inhibitor	99.80%	Unkown
HY-152107	LRRK2-IN-7	Inhibitor	98.03%	Unkown
HY-156429	MK-1468	Inhibitor	99.69%	Unkown
HY-B0792	CZC-54252	Inhibitor	98.05%	Unkown
HY-142647	EB-42486	Inhibitor	99.62%	Unkown
HY-163064	CC-3240	Degrader	99.24%	Unkown
HY-16936	JH-II-127	Inhibitor	98.0%	Unkown
HY-18163A	GNE-7915 tosylate	Inhibitor	99.06%	Unkown
HY-112855	PF-06454589	Inhibitor	99.91%	Unkown
HY-W107722	IN04		98.51%	Unkown
HY-148353	PF-06455943	Inhibitor	98.21%	Unkown
HY-75368	SRI-31255	Inhibitor	99.88%	Unkown
HY-174427	RN341	Inhibitor	/	Unkown
HY-174420	RN277	Inhibitor	/	Unkown
HY-152107A	(R,R)-LRRK2-IN-7	Inhibitor	/	Unkown
HY-145317	LRRK2-IN-2	Inhibitor	/	Unkown
HY-145318	LRRK2-IN-3	Inhibitor	/	Unkown
HY-180320	Lu AF58786	Inhibitor	/	Unkown
HY-165543	SRI-29132	Inhibitor	/	Unkown
HY-186110	PROTAC LRRK2 Degrader-5	Degrader	/	Unkown
HY-153058	LRRK2-IN-8	Inhibitor	/	Unkown
HY-144074	LRRK2-IN-4	Inhibitor	/	Unkown
HY-182928	LRRK2-IN-21	Inhibitor	/	Unkown
HY-153103	LRRK2/NUAK1/TYK2-IN-1	Inhibitor	/	Unkown
HY-184652	LRRK2/JNK3-IN-1	Inhibitor	/	Unkown
HY-175651	LRRK2-IN-20	Inhibitor	/	Unkown
HY-161571	LRRK2-IN-13	Inhibitor	/	Unkown
HY-134562	PF-06371900	Inhibitor	99.43%	Unkown
HY-158365	LRRK2-IN-14	Inhibitor	/	Unkown
HY-177016	LRRK2-IN-19	Inhibitor	/	Unkown
HY-151444	LRRK2-IN-6	Inhibitor	/	Unkown
HY-168041	LRRK2-IN-15	Inhibitor	/	Unkown
HY-161570	LRRK2-IN-12	Inhibitor	/	Unkown
HY-169576	LRRK2-IN-16	Inhibitor	/	Unkown
HY-184198	LRRK2-IN-22	Inhibitor	/	Unkown
HY-178796	PROTAC LRRK2 Degrader-4	Degrader	/	Unkown
HY-B0792A	CZC-54252 hydrochloride	Inhibitor	98.44%	Unkown
HY-171801	PROTAC LRRK2 Degrader-1	Degrader	/	Unkown
HY-151441	LRRK2-IN-5	Inhibitor	/	Unkown
HY-172952	LRRK2-IN-17	Inhibitor	/	Unkown
HY-178797	PROTAC LRRK2 Degrader-3	Degrader	/	Unkown
HY-162699	LY2023-001	Inhibitor	/	Unkown
HY-171802	PROTAC LRRK2 Degrader-2	Degrader	/	Unkown
HY-156167	LRRK2-IN-10	Inhibitor	/	Unkown
HY-181046	Multi-kinase-IN-14	Inhibitor	/	Unkown
HY-P10636	Nictide		/	Unkown
HY-169900	FX 2149	Inhibitor	/	Unkown
HY-15800	CZC-25146 hydrochloride	Inhibitor	/	Unkown
HY-149187	LRRK2-IN-9	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	LRRK2	VGNC	VGNC:97488
Rattus norvegicus	LRRK2	RGD	RGD:1561168
Bos taurus	LRRK2	VGNC	VGNC:31038
Mus musculus	LRRK2	MGD	MGI:1913975
Canis familiaris	LRRK2	VGNC	VGNC:42823
Macaca mulatta	LRRK2	VGNC	VGNC:81447
Others	LRRK2	NCBI