1. Autophagy
  2. LRRK2

LRRK2 inhibitor 1 

Cat. No.: HY-111493
Handling Instructions

LRRK2 inhibitor 1 is a potent, selective and oral LRRK2 inhibitor with an pIC50 of 6.8 nM.

For research use only. We do not sell to patients.

LRRK2 inhibitor 1 Chemical Structure

LRRK2 inhibitor 1 Chemical Structure

CAS No. : 1802525-61-6

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Customer Review

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

LRRK2 inhibitor 1 is a potent, selective and oral LRRK2 inhibitor with an pIC50 of 6.8 nM.

IC50 & Target

pIC50: 6.8 nM (LRRK2)[1]

Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (157.26 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5162 mL 12.5808 mL 25.1617 mL
5 mM 0.5032 mL 2.5162 mL 5.0323 mL
10 mM 0.2516 mL 1.2581 mL 2.5162 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.08 mg/mL (5.23 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.23 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.23 mM); Clear solution

References
Molecular Weight

397.43

Formula

C₂₀H₂₃N₅O₄

CAS No.

1802525-61-6

SMILES

CCOC1=NC(NC2=C(OC)C=C(C(N3CCOCC3)=O)C=C2)=NC4=C1C=CN4

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
LRRK2 inhibitor 1
Cat. No.:
HY-111493
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LRRK2 inhibitor 1

Cat. No.: HY-111493