NDUFAF7 - NADH:ubiquinone oxidoreductase complex assembly factor 7 Gene

Also Known as MidA; C2orf56; PRO1853

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55471

Summary

This gene encodes an assembly factor protein which helps in the assembly and stabilization of Complex I, a large multi-subunit enzyme in the mitochondrial respiratory chain. Complex I is involved in several physiological activities in the cell, including metabolite transport and ATP synthesis. The encoded protein is a methyltransferase which methylates Arg85 of a subunit of Complex I in the early stages of its assembly. A pseudogene related to this gene is located on chromosome 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
Ubiquitous expression in testis (RPKM 15.9), fat (RPKM 9.7) and 25 other tissues.

NDUFAF7 Products (1)

mRNA Protein Name
NG_053078.1 [RefSeqGene]

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables enzyme binding IPI
IPI: Inferred from physical interaction
20406883 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
24089531 GOA
enables protein-arginine omega-N symmetric methyltransferase activity IMP
IMP: Inferred from mutant phenotype
24089531 GOA
Biological Process GO Annotation Evidence References Source
involved in mitochondrial respiratory chain complex I assembly IMP
IMP: Inferred from mutant phenotype
20406883 GOA
involved in peptidyl-arginine methylation, to symmetrical-dimethyl arginine IMP
IMP: Inferred from mutant phenotype
24089531 GOA
Cellular Component GO Annotation Evidence References Source
located in mitochondrion IDA
IDA: Inferred from direct assay
20406883 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NDUFAF7 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NDUFAF7 Q7L592 LRRK2 Homo sapiens Q5S007
Protein Array
29513927
Cross: Cross-species interaction Intra: Intraspecies interaction