WSB1 - WD repeat and SOCS box containing 1 Gene

Also Known as SWIP1; WSB-1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 26118

About WSB1

Cytogenetic location: 17q11.1 Genomic coordinates (GRCh38): 17:27,294,114-27,315,926 (from NCBI)

This gene has 17 transcripts (splice variants), 214 orthologues and 1 paralogue. Ubiquitous expression in spleen (RPKM 64.5), lung (RPKM 63.6) and 25 other tissues.

Summary

This gene encodes a member of the WD-protein subfamily. This protein shares a high sequence identity to mouse and chick proteins. It contains several WD-repeats spanning most of the protein and an SOCS box in the C-terminus. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

WSB1 Products (3)

mRNA Protein Name
NM_001348350.2 NP_001335279.1 WD repeat and SOCS box-containing protein 1 isoform 3
NM_015626.10 NP_056441.6 WD repeat and SOCS box-containing protein 1 isoform 1
NM_134265.4 NP_599027.1 WD repeat and SOCS box-containing protein 1 isoform 2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
18093972 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WSB1 Protein Structure

WD40

WD40: WD domain, G-beta repeat (161 - 199)

WD40

WD40: WD domain, G-beta repeat (207 - 242)

WD40

WD40: WD domain, G-beta repeat (249 - 284)

WD40

WD40: WD domain, G-beta repeat (308 - 338)

WD40

WD40: WD domain, G-beta repeat (356 - 378)

SOCS_box

SOCS_box: SOCS box (384 - 420)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 421 a.a.
Protein Preferred Names Protein Names

WD repeat and SOCS box-containing protein 1

  • SOCS box-containing WD protein SWiP-1

WSB1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
WSB1 Q9Y6I7 VHL Homo sapiens P40337-2
Validated Y2H
32814053
Intra
WSB1 Q9Y6I7 VHL Homo sapiens P40337-2
Y2H Array
32814053
Intra
WSB1 Q9Y6I7 VHL Homo sapiens P40337-2
Y2H Pooling
32814053
Cross
WSB1 Q9Y6I7 Hipk2 Mus musculus Q9QZR5
Anti Tag CoIP
18093972
Cross
WSB1 Q9Y6I7 Hipk2 Mus musculus Q9QZR5
Pull Down
18093972
Intra
WSB1 Q9Y6I7 LRRK2 Homo sapiens Q5S007
Confocal
27273569
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-141482 WSB1 Degrader 1 Inhibitor 99.81% Unkown
HY-RS15849 WSB1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20350 Wsb1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26859 Wsb1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus WSB1 MGD MGI:1926139
Macaca mulatta WSB1 VGNC VGNC:79186
Felis catus WSB1 VGNC VGNC:67091
Canis familiaris WSB1 VGNC VGNC:48435
Bos taurus WSB1 VGNC VGNC:36971
Rattus norvegicus WSB1 RGD RGD:1307835
Others WSB1 NCBI