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Hipk2 - homeodomain interacting protein kinase 2 Gene

Also Known as Stank; 1110014O20Rik; B230339E18Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 15258

Summary

Enables RNA polymerase II-specific DNA-binding transcription factor binding activity; protein serine/threonine kinase activity; and transcription corepressor activity. Contributes to transcription coactivator activity. Involved in several processes, including camera-type eye morphogenesis; protein phosphorylation; and regulation of transcription, DNA-templated. Acts upstream of or within several processes, including adult walking behavior; cell surface receptor signaling pathway; and intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator. Located in cytoplasm and nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; metanephros; paraxial mesenchyme; and sensory organ. Orthologous to human HIPK2 (homeodomain interacting protein kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Hipk2 Products (4)

mRNA	Protein	Name
NM_001136065.2	NP_001129537.1	homeodomain-interacting protein kinase 2 isoform 1
NM_001294143.1	NP_001281072.1	homeodomain-interacting protein kinase 2 isoform 3
NM_001294144.1	NP_001281073.1	homeodomain-interacting protein kinase 2 isoform 4
NM_010433.2	NP_034563.2	homeodomain-interacting protein kinase 2 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
NOT enables DNA binding	IDA IDA: Inferred from direct assay	9748262	MGI
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	16407227	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9748262	MGI
enables protein kinase activity	IDA IDA: Inferred from direct assay	9748262	MGI
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	16407227	MGI
contributes to transcription coactivator activity	IMP IMP: Inferred from mutant phenotype	16407227	MGI
enables transcription corepressor activity	IDA IDA: Inferred from direct assay	9748262	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within adult locomotory behavior	IMP IMP: Inferred from mutant phenotype	17159989	MGI
acts upstream of or within adult walking behavior	IMP IMP: Inferred from mutant phenotype	17159989	MGI
acts upstream of or within anterior/posterior pattern specification	IGI IGI: Inferred from genetic interaction	16537918	MGI
acts upstream of cell population proliferation	IGI IGI: Inferred from genetic interaction	16537918	MGI
involved in embryonic camera-type eye morphogenesis	IMP IMP: Inferred from mutant phenotype	20579985	MGI
involved in embryonic retina morphogenesis in camera-type eye	IMP IMP: Inferred from mutant phenotype	20579985	MGI
acts upstream of or within gene expression	IGI IGI: Inferred from genetic interaction	31582725	MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IGI IGI: Inferred from genetic interaction	16537918	MGI
involved in iris morphogenesis	IMP IMP: Inferred from mutant phenotype	20579985	MGI
involved in lens induction in camera-type eye	IMP IMP: Inferred from mutant phenotype	20579985	MGI
acts upstream of or within lung morphogenesis	IGI IGI: Inferred from genetic interaction	31582725	MGI
acts upstream of or within negative regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	17159989	MGI
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9748262	MGI
acts upstream of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	17159989	MGI
involved in neuron differentiation	IMP IMP: Inferred from mutant phenotype	20579985	MGI
involved in peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	16407227	MGI
involved in peptidyl-threonine phosphorylation	IDA IDA: Inferred from direct assay	16407227	MGI
involved in positive regulation of DNA binding	IDA IDA: Inferred from direct assay	9748262	MGI
involved in positive regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	16407227	MGI
acts upstream of or within positive regulation of cell population proliferation	IGI IGI: Inferred from genetic interaction	16537918	MGI
involved in positive regulation of protein binding	IDA IDA: Inferred from direct assay	16407227	MGI
acts upstream of or within positive regulation of protein phosphorylation	IGI IGI: Inferred from genetic interaction	20360400	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	17159989	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	16407227	MGI
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	9748262	MGI
acts upstream of protein phosphorylation	IGI IGI: Inferred from genetic interaction	20360400	MGI
acts upstream of or within respiratory system process	IGI IGI: Inferred from genetic interaction	31582725	MGI
involved in retina layer formation	IMP IMP: Inferred from mutant phenotype	20579985	MGI
acts upstream of or within smoothened signaling pathway	IGI IGI: Inferred from genetic interaction	16537918	MGI
acts upstream of or within thyroid gland development	IGI IGI: Inferred from genetic interaction	31582725	MGI
acts upstream of or within transforming growth factor beta receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	17159989	MGI
acts upstream of or within voluntary musculoskeletal movement	IMP IMP: Inferred from mutant phenotype	17159989	MGI

Cellular Component GO Annotation	Evidence	References	Source
part of RNA polymerase II transcription regulator complex	IMP IMP: Inferred from mutant phenotype	16407227	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	11078605	MGI
located in nucleus	IDA IDA: Inferred from direct assay	9748262	MGI
part of protein-containing complex	IDA IDA: Inferred from direct assay	16870469	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
homeodomain-interacting protein kinase 2	nuclear body-associated kinase 1 sialophorin tail-associated nuclear serine/threonine-protein kinase

Hipk2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	Hipk2	Q9QZR5	WSB1	Homo sapiens	Q9Y6I7	Pull Down	18093972
Cross	Hipk2	Q9QZR5	MECP2	Homo sapiens	P51608	Anti Bait CoIP	19820693
Intra	Hipk2	Q9QZR5	Nlk	Mus musculus	O54949	Y2H	15082531
Intra	Hipk2	Q9QZR5	Myb	Mus musculus	P06876	Y2H	15082531
Intra	Hipk2	Q9QZR5	Mef2c	Mus musculus	Q8CFN5	Anti Bait CoIP	23565059

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (13)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100464	tBID	Inhibitor	98.24%	Unkown
HY-U00439A	Protein kinase inhibitor 1 hydrochloride	Inhibitor	98.0%	Unkown
HY-135906	CK2/ERK8-IN-1		99.0%	Unkown
HY-128439	BT173	Inhibitor	98.71%	Unkown
HY-U00439	Protein kinase inhibitor 1	Inhibitor	≥99.0%	Unkown
HY-122670	VS-II-173		/	Unkown
HY-177416	MU1787	Inhibitor	/	Unkown
HY-179378	XRF-1021	Inhibitor	/	Unkown
HY-E70830	HIPK2 Recombinant Human Active Protein Kinase		/	Unkown
HY-RS06182	HIPK2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W152736	2-Methyl-5-acetylphenol		90%	Unkown
HY-RS16856	Hipk2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23297	Hipk2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hipk2	NCBI	NCBI:28996