2. Protein Tyrosine Kinase/RTK
  3. DYRK
  4. 2-Methyl-5-acetylphenol

2-Methyl-5-acetylphenol is a hydroxylated methylacetophenone that exists in the aerial parts of Cannabis sativa subsp. sativa. 2-Methyl-5-acetylphenol exhibits strong binding affinity to HIPK2. 2-Methyl-5-acetylphenol cannot reverse MPP+ (1-methyl-4-phenyl-pyridinium ion)-induced neuronal cytotoxicity. 2-Methyl-5-acetylphenol can be used for Parkinson's disease research.

For research use only. We do not sell to patients.

2-Methyl-5-acetylphenol

2-Methyl-5-acetylphenol Chemical Structure

CAS No. : 33414-49-2

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

2-Methyl-5-acetylphenol Related Antibodies

Top Publications Citing Use of Products

View All DYRK Isoform Specific Products:

View All Isoforms
DYRK1 DYRK2 DYRK3 DYRK4 HIPK PRP4

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

2-Methyl-5-acetylphenol is a hydroxylated methylacetophenone that exists in the aerial parts of Cannabis sativa subsp. sativa. 2-Methyl-5-acetylphenol exhibits strong binding affinity to HIPK2. 2-Methyl-5-acetylphenol cannot reverse MPP+ (1-methyl-4-phenyl-pyridinium ion)-induced neuronal cytotoxicity. 2-Methyl-5-acetylphenol can be used for Parkinson's disease research[1].

IC50 & Target[1]

HIPK2

 

In Vitro

2-Methyl-5-acetylphenol (Compound 9) (12.5-100 μM; treatment for 24 h) fails to reverse MPP+-induced cytotoxicity in SH-SY5Y cells at concentrations ranging from 12.5 to 100 μM; instead, it exacerbates such cytotoxicity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

2-Methyl-5-acetylphenol Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: human neuroblastoma SH-SY5Y cells
Concentration: 12.5, 25, 50, 100 μM
Incubation Time: 24 h
Result: Recorded cell viability of 97.83%, 99.78%, 98.17%, and 96.25% when applied alone at 12.5, 25, 50, and 100 μM, respectively.
Detected cell viability of 33.75%, 38.41%, 38.98%, and 39.27% when applied in combination with 1.8 mM MPP⁺ at 12.5, 25, 50, and 100 μM, respectively.
Calculated rescue effect of -24.29%, -13.84%, -12.56%, and -11.91% at 12.5, 25, 50, and 100 μM, respectively.
Molecular Weight

150.17

Formula

C9H10O2
CAS No.
Appearance

Solid

SMILES

CC1=C(C=C(C=C1)C(=O)C)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

2-Methyl-5-acetylphenol Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2-Methyl-5-acetylphenol33414-49-2DYRKDual specificity tyrosine phosphorylation regulated kinaseDual specificity tyrosine regulated kinaseSH-SY5Y cellsMPP+HIPK2neuronal cellsCannabis sativa subsp. sativaATP-binding pocketInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
2-Methyl-5-acetylphenol
Cat. No.:
HY-W152736
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.