2-Methyl-5-acetylphenol
2-Methyl-5-acetylphenol is a hydroxylated methylacetophenone that exists in the aerial parts of Cannabis sativa subsp. sativa. 2-Methyl-5-acetylphenol exhibits strong binding affinity to HIPK2. 2-Methyl-5-acetylphenol cannot reverse MPP+ (1-methyl-4-phenyl-pyridinium ion)-induced neuronal cytotoxicity. 2-Methyl-5-acetylphenol can be used for Parkinson's disease research.
For research use only. We do not sell to patients.
- CAS No.: 33414-49-2
- Formula: C9H10O2
- Molecular Weight:150.17
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
HIPK2 |
In Vitro
2-Methyl-5-acetylphenol (Compound 9) (12.5-100 μM; treatment for 24 h) fails to reverse MPP+-induced cytotoxicity in SH-SY5Y cells at concentrations ranging from 12.5 to 100 μM; instead, it exacerbates such cytotoxicity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human neuroblastoma SH-SY5Y cells
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Concentration:12.5, 25, 50, 100 μM
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Incubation Time:24 h
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Result:Recorded cell viability of 97.83%, 99.78%, 98.17%, and 96.25% when applied alone at 12.5, 25, 50, and 100 μM, respectively.
Detected cell viability of 33.75%, 38.41%, 38.98%, and 39.27% when applied in combination with 1.8 mM MPP⁺ at 12.5, 25, 50, and 100 μM, respectively.
Calculated rescue effect of -24.29%, -13.84%, -12.56%, and -11.91% at 12.5, 25, 50, and 100 μM, respectively.
Chemical Information
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CAS No. 33414-49-2
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Appearance Solid
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Molecular Weight 150.17
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Formula C9H10O2
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Color Off-white to light yellow
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SMILES
CC1=C(C=C(C=C1)C(=O)C)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (273 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
2-Methyl-5-acetylphenol Related Classifications
HY-W152736 Related Classifications
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