HIPK2
HIPK2 is the best-characterized homeodomain-interacting protein kinase and a nuclear regulator of cell-fate decisions. Its defining activity is phosphorylation of p53 at Tyr90, a modification that promotes apoptotic gene induction after genotoxic stress. HIPK2 also binds homeodomain transcription factors through its interaction domain, recruits and phosphorylates the CtBP corepressor to relieve repression, and participates in Wnt-β-catenin and TGF-β signaling, with documented roles in eye and neural development. Its abundance is controlled by SUMOylation, ubiquitination, and proteasomal degradation. Because it links DNA damage to apoptosis, HIPK2 is a recurring topic in chemosensitization studies. Recombinant HIPK2 supports these and inhibitor-discovery applications.
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HIPK2 Recombinant Proteins (1)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
