country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

HIPK2 - homeodomain interacting protein kinase 2 Gene

Also Known as PRO0593

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 28996

About HIPK2

Cytogenetic location: 7q34 Genomic coordinates (GRCh38): 7:139,561,570-139,777,998 (from NCBI)

This gene has 3 transcripts (splice variants), 213 orthologues and 12 paralogues. Ubiquitous expression in brain (RPKM 22.7), kidney (RPKM 17.9) and 24 other tissues.

Summary

This gene encodes a conserved serine/threonine kinase that is a member of the homeodomain-interacting protein kinase family. The encoded protein interacts with homeodomain transcription factors and many Other transcription factors such as p53, and can function as both a corepressor and a coactivator depending on the transcription factor and its subcellular localization. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

HIPK2 Products (2)

mRNA	Protein	Name
NM_001113239.3	NP_001106710.1	homeodomain-interacting protein kinase 2 isoform 2
NM_022740.5	NP_073577.3	homeodomain-interacting protein kinase 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	14647468	GOA
enables SMAD binding	IPI IPI: Inferred from physical interaction	12874272	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12220523	GOA
enables protein kinase activity	IDA IDA: Inferred from direct assay	19448668	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	33591310	GOA
enables transcription corepressor activity	IDA IDA: Inferred from direct assay	12874272	GOA
enables virion binding	IPI IPI: Inferred from physical interaction	14990717	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA damage response, signal transduction by p53 class mediator	IDA IDA: Inferred from direct assay	14647468	GOA
involved in SMAD protein signal transduction	IDA IDA: Inferred from direct assay	12874272	GOA
involved in negative regulation of BMP signaling pathway	IMP IMP: Inferred from mutant phenotype	12874272	GOA
involved in negative regulation of ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	21628596	GOA
involved in peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	33591310	GOA
involved in positive regulation of JNK cascade	IMP IMP: Inferred from mutant phenotype	14678985	GOA
involved in positive regulation of angiogenesis	IDA IDA: Inferred from direct assay	19046997	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	14647468	GOA
involved in positive regulation of transforming growth factor beta receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	14678985	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	19448668	GOA

Cellular Component GO Annotation	Evidence	References	Source
colocalizes with PML body	IDA IDA: Inferred from direct assay	14647468	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	33591310	GOA
located in cytoplasmic stress granule	IDA IDA: Inferred from direct assay	33591310	GOA
located in nuclear body	IDA IDA: Inferred from direct assay	12874272	GOA
located in nucleus	IDA IDA: Inferred from direct assay	12220523	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HIPK2 Protein Structure

Pkinase

0
200
400
600
800
1000
1198 a.a.

Protein Preferred Names	Protein Names
homeodomain-interacting protein kinase 2	hHIPk2

HIPK2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	HIPK2	Q9H2X6	MECP2	Homo sapiens	P51608	Anti Bait CoIP	19820693
Intra	HIPK2	Q9H2X6	TP63	Homo sapiens	Q9H3D4	Protein Kinase Assay	21602882
Intra	HIPK2	Q9H2X6	DCAF7	Homo sapiens	P61962	Anti Tag CoIP	20940704
Intra	HIPK2	Q9H2X6	DCAF7	Homo sapiens	P61962	Y2H	20940704
Intra	HIPK2	Q9H2X6	DCAF7	Homo sapiens	P61962	Pull Down	20940704
Intra	HIPK2	Q9H2X6	EP300	Homo sapiens	Q09472	Pull Down	16917507
Intra	HIPK2	Q9H2X6	RUNX1	Homo sapiens	Q01196	Pull Down	16917507
Intra	HIPK2	Q9H2X6	RUNX1	Homo sapiens	Q01196	Anti Bait CoIP	16917507
Intra	HIPK2	Q9H2X6	RUNX1	Homo sapiens	Q01196	Protein Kinase Assay	16917507

Cross: Cross-species interaction Intra: Intraspecies interaction

HIPK2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82168	HIPK2 Antibody (YA1913)	WB, ICC/IF, IP, FC	Human, Mouse

Related Diseases

Diseases	Alias
Keratoacanthoma	Ka - [Keratoacanthoma] Well-Differentiated Squamous Cell Carcinoma
Encephalopathy, Neonatal Severe, Due To Mecp2 Mutations	Severe Congenital Encephalopathy Due To Mecp2 Mutation Severe Neonatal-Onset Encephalopathy With Microcephaly Encephalopathy, Neonatal Severe Neonatal Severe Encephalopathy Due To Mecp2 Mutations Mecp2-Related Severe Neonatal Encephalopathy Methyl-Cytosine Phosphate Guanine Binding Protein 2 Related Severe Neonatal Encephalopathy Severe Neonatal Encephalopathy Due To Mecp2 Mutations ENS-MECP2 Encephalopathy, Neonatal, Severe
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (13)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100464	tBID	Inhibitor	98.24%	Unkown
HY-U00439A	Protein kinase inhibitor 1 hydrochloride	Inhibitor	98.0%	Unkown
HY-135906	CK2/ERK8-IN-1		99.0%	Unkown
HY-128439	BT173	Inhibitor	98.71%	Unkown
HY-U00439	Protein kinase inhibitor 1	Inhibitor	≥99.0%	Unkown
HY-122670	VS-II-173		/	Unkown
HY-177416	MU1787	Inhibitor	99.84%	Unkown
HY-179378	XRF-1021	Inhibitor	/	Unkown
HY-E70830	HIPK2 Recombinant Human Active Protein Kinase		/	Unkown
HY-RS06182	HIPK2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W152736	2-Methyl-5-acetylphenol		90%	Unkown
HY-RS16856	Hipk2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23297	Hipk2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	HIPK2	MGD	MGI:1314872
Macaca mulatta	HIPK2	VGNC	VGNC:73391
Rattus norvegicus	HIPK2	RGD	RGD:1309349
Bos taurus	HIPK2	VGNC	VGNC:58380
Canis familiaris	HIPK2	VGNC	VGNC:41694
Felis catus	HIPK2	VGNC	VGNC:62820
Others	HIPK2	NCBI