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DCAF7 - DDB1 and CUL4 associated factor 7 Gene

Also Known as AN11; HAN11; WDR68; SWAN-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10238

About DCAF7

Cytogenetic location: 17q23.3 Genomic coordinates (GRCh38): 17:63,550,477-63,594,266 (from NCBI)

This gene has 19 transcripts (splice variants) and 246 orthologues. Ubiquitous expression in kidney (RPKM 18.2), brain (RPKM 17.9) and 25 other tissues.

Summary

This gene encodes a protein with multiple WD40 repeats which facilitate protein-protein interactions and thereby enable the assembly of multiprotein complexes. This protein has been shown to function as a scaffold protein for protein complexes involved in kinase signaling. This highly conserved gene is present in eukaryotic Plants, fungi, and Animals. The ortholog of this gene was first identified in Plants as a key regulator of anthocyanin biosynthesis and flower pigmentation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

DCAF7 Products (1)

mRNA	Protein	Name
NM_005828.5	NP_005819.3	DDB1- and CUL4-associated factor 7

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14593110	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of Cul4-RING E3 ubiquitin ligase complex	IDA IDA: Inferred from direct assay	16949367	GOA
located in nuclear matrix	IDA IDA: Inferred from direct assay	21328542	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	21328542	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
DDB1- and CUL4-associated factor 7	WD repeat-containing protein 68

DCAF7 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	DCAF7	P61962	DYRK1A	Homo sapiens	Q13627	IF	20940704
Intra	DCAF7	P61962	DYRK1A	Homo sapiens	Q13627	Proximity Labelling	35016035
Intra	DCAF7	P61962	DYRK1A	Homo sapiens	Q13627	TAP	27705803
Intra	DCAF7	P61962	DYRK1A	Homo sapiens	Q13627	Anti Tag CoIP	35016035
Intra	DCAF7	P61962	DYRK1A	Homo sapiens	Q13627	Anti Tag CoIP	20940704
Intra	DCAF7	P61962	DYRK1A	Homo sapiens	Q13627	Anti Tag CoIP	33961781
Intra	DCAF7	P61962	DYRK1A	Homo sapiens	Q13627	TAP	27173435
Intra	DCAF7	P61962	ATN1	Homo sapiens	Q86V38	Y2H Array	32814053
Intra	DCAF7	P61962	ATN1	Homo sapiens	Q86V38	Y2H Pooling	32814053
Intra	DCAF7	P61962	ATN1	Homo sapiens	Q86V38	Validated Y2H	32814053
Intra	DCAF7	P61962	LAMP2	Homo sapiens	P13473-2	Validated Y2H	32814053
Intra	DCAF7	P61962	LAMP2	Homo sapiens	P13473-2	Y2H Array	32814053
Intra	DCAF7	P61962	LAMP2	Homo sapiens	P13473-2	Y2H Pooling	32814053
Intra	DCAF7	P61962	KLK6	Homo sapiens	Q92876	Y2H Pooling	32814053
Intra	DCAF7	P61962	KLK6	Homo sapiens	Q92876	Validated Y2H	32814053
Intra	DCAF7	P61962	KLK6	Homo sapiens	Q92876	Y2H Array	32814053
Intra	DCAF7	P61962	HIPK2	Homo sapiens	Q9H2X6	Anti Tag CoIP	20940704
Intra	DCAF7	P61962	HIPK2	Homo sapiens	Q9H2X6	Anti Tag CoIP	33961781
Intra	DCAF7	P61962	HIPK2	Homo sapiens	Q9H2X6	IF	20940704
Intra	DCAF7	P61962	TARDBP	Homo sapiens	Q13148	Validated Y2H	32814053
Intra	DCAF7	P61962	TARDBP	Homo sapiens	Q13148	Y2H Array	32814053
Intra	DCAF7	P61962	TARDBP	Homo sapiens	Q13148	Y2H Pooling	32814053
Intra	DCAF7	P61962	MAP3K1	Homo sapiens	Q13233	IF	20940704
Intra	DCAF7	P61962	DYRK1B	Homo sapiens	Q9Y463	TAP	27705803
Intra	DCAF7	P61962	DYRK1B	Homo sapiens	Q9Y463	Anti Tag CoIP	35016035
Intra	DCAF7	P61962	DYRK1B	Homo sapiens	Q9Y463	Anti Tag CoIP	20940704
Intra	DCAF7	P61962	DYRK1B	Homo sapiens	Q9Y463	Anti Tag CoIP	33961781
Intra	DCAF7	P61962	CASP6	Homo sapiens	P55212	Y2H Pooling	32814053
Intra	DCAF7	P61962	CASP6	Homo sapiens	P55212	Validated Y2H	32814053
Intra	DCAF7	P61962	CASP6	Homo sapiens	P55212	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Noonan Syndrome 4	NS4 Noonan Syndrome, Type 4
Abdominal Obesity-Metabolic Syndrome 3	AOMS3 Central Obesity, Type 2 Diabetes, Hypertension, And Early-Onset Coronary Artery Disease Obesity, Abdominal, Metabolic Syndrome, Type 3
Intellectual Developmental Disorder, Autosomal Dominant 7	MRD7 Mental Retardation, Autosomal Dominant 7 Autosomal Dominant Non-Syndromic Intellectual Disability 7 Dyrk1a Syndrome Autosomal Dominant Intellectual Developmental Disorder 7 Autosomal Dominant Mental Retardation 7 Mental Retardation, Autosomal Dominant, Type 7
Epidermodysplasia Verruciformis 1	Epidermodysplasia Verruciformis Epidermodysplasia Verruciformis, Susceptibility To, 1 Lutz-Lewandowsky Epidermodysplasia Verruciformis EV1 Lewandowsky-Lutz Syndrome Ev

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03567	DCAF7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20389	Dcaf7 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26898	Dcaf7 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	DCAF7	RGD	RGD:1305140
Bos taurus	DCAF7	VGNC	VGNC:27907
Mus musculus	DCAF7	MGD	MGI:1919083
Macaca mulatta	DCAF7	VGNC	VGNC:71820
Felis catus	DCAF7	VGNC	VGNC:61360
Canis familiaris	DCAF7	VGNC	VGNC:39796
Others	DCAF7	NCBI