DCAF7 - DDB1 and CUL4 associated factor 7 Gene

Homo sapiens

Also known as AN11; HAN11; WDR68; SWAN-1

Gene ID: 10238 | Gene type: protein coding

About DCAF7

Cytogenetic location: 17q23.3 Genomic coordinates (GRCh38): 17:63,550,477-63,594,266 (from NCBI)

This gene has 19 transcripts (splice variants) and 246 orthologues. Ubiquitous expression in kidney (RPKM 18.2), brain (RPKM 17.9) and 25 other tissues.

Summary

This gene encodes a protein with multiple WD40 repeats which facilitate protein-protein interactions and thereby enable the assembly of multiprotein complexes. This protein has been shown to function as a scaffold protein for protein complexes involved in kinase signaling. This highly conserved gene is present in eukaryotic Plants, fungi, and Animals. The ortholog of this gene was first identified in Plants as a key regulator of anthocyanin biosynthesis and flower pigmentation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

DCAF7 Products(1)

mRNA	Protein	Name
NM_005828.5	NP_005819.3	DDB1- and CUL4-associated factor 7

Protein Preferred Names

Protein Names

DDB1- and CUL4-associated factor 7

WD repeat-containing protein 68

Related Diseases

Diseases

Alias

Noonan Syndrome 4

NS4	Noonan Syndrome, Type 4

Abdominal Obesity-Metabolic Syndrome 3

AOMS3	Central Obesity, Type 2 Diabetes, Hypertension, And Early-Onset Coronary Artery Disease
Obesity, Abdominal, Metabolic Syndrome, Type 3

Intellectual Developmental Disorder, Autosomal Dominant 7

MRD7	Mental Retardation, Autosomal Dominant 7
Autosomal Dominant Non-Syndromic Intellectual Disability 7	Dyrk1a Syndrome
Autosomal Dominant Intellectual Developmental Disorder 7	Autosomal Dominant Mental Retardation 7
Mental Retardation, Autosomal Dominant, Type 7

Epidermodysplasia Verruciformis 1

Epidermodysplasia Verruciformis	Epidermodysplasia Verruciformis, Susceptibility To, 1
Lutz-Lewandowsky Epidermodysplasia Verruciformis	EV1
Lewandowsky-Lutz Syndrome	Ev

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03567	DCAF7 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	DCAF7	RGD	RGD:1305140
Bos taurus	DCAF7	VGNC	VGNC:27907
Mus musculus	DCAF7	MGD	MGI:1919083
Macaca mulatta	DCAF7	VGNC	VGNC:71820
Felis catus	DCAF7	VGNC	VGNC:61360
Canis familiaris	DCAF7	VGNC	VGNC:39796
Others	DCAF7	NCBI

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