MAP3K1 - mitogen-activated protein kinase kinase kinase 1 Gene

Also Known as MEKK; MEKK1; SRXY6; MEKK 1; MAPKKK1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4214

About MAP3K1

Cytogenetic location: 5q11.2 Genomic coordinates (GRCh38): 5:56,815,549-56,896,152 (from NCBI)

This gene has 2 transcripts (splice variants), 161 orthologues, 35 paralogues and is associated with 105 phenotypes. Ubiquitous expression in spleen (RPKM 8.6), skin (RPKM 8.4) and 25 other tissues.

Summary

The protein encoded by this gene is a serine/threonine kinase and is part of some signal transduction cascades, including the ERK and JNK kinase pathways as well as the NF-kappa-B pathway. The encoded protein is activated by autophosphorylation and requires magnesium as a cofactor in phosphorylating Other proteins. This protein has E3 Ligase activity conferred by a plant homeodomain (PHD) in its N-terminus and phospho-kinase activity conferred by a kinase domain in its C-terminus. [provided by RefSeq, Mar 2012]

MAP3K1 Products (1)

mRNA	Protein	Name
NM_005921.2	NP_005912.1	mitogen-activated protein kinase kinase kinase 1

MAP3K1 Protein Structure

Pkinase

0
300
600
900
1200
1512 a.a.

Protein Preferred Names	Protein Names
mitogen-activated protein kinase kinase kinase 1	MAP/ERK kinase kinase 1

MAP3K1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MAP3K1	Q13233	DCAF7	Homo sapiens	P61962	TAP	14743216
Intra	MAP3K1	Q13233	DCAF7	Homo sapiens	P61962	Anti Tag CoIP	20940704
Intra	MAP3K1	Q13233	BRAF	Homo sapiens	P15056	Protein Kinase Assay	16810323
Intra	MAP3K1	Q13233	BRAF	Homo sapiens	P15056	Anti Bait CoIP	16888650
Intra	MAP3K1	Q13233	MAP2K4	Homo sapiens	P45985	Protein Kinase Assay	9808624
Intra	MAP3K1	Q13233	MAP2K4	Homo sapiens	P45985	Pull Down	9808624
Intra	MAP3K1	Q13233	MAP4K2	Homo sapiens	Q12851	Anti Bait CoIP	11784851

Cross: Cross-species interaction Intra: Intraspecies interaction

MAP3K1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P810138	MEK kinase-1 Antibody (YA9482)	WB, IP	human

Related Diseases

Diseases	Alias
46,Xy Sex Reversal 6	SRXY6 46,Xy Sex Reversal, Partial Or Complete, Map3k1-Related 46,Xy Gonadal Dysgenesis, Partial Or Complete, Map3k1-Related 46xy Sex Reversal 6 46,Xy Gonadal Dysgenesis Partial Or Complete Map3k1-Related 46,Xy Sex Reversal Partial Or Complete Map3k1-Related
46,Xy Partial Gonadal Dysgenesis	46,Xy Pgd 46,Xy Partial Testicular Dysgenesis
46,Xy Sex Reversal	Swyer Syndrome Pure Gonadal Dysgenesis 46,Xy Gonadal Dysgenesis, Xy Female Type Gonadal Dysgenesis, 46,Xy 46,Xy Cgd 46,Xy Complete Gonadal Dysgenesis 46,Xy Pure Gonadal Dysgenesis 46 Xy Gonadal Dysgenesis 46, Xy Cgd 46, Xy Complete Gonadal Dysgenesis 46, Xy Pure Gonadal Dysgenesis Xy Pure Gonadal Dysgenesis Female With 46,Xy Karyotype Xy Females
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Gonadal Dysgenesis	Gonadal Dysgenesis Syndrome Turner Syndrome
Ciliary Dyskinesia, Primary, 5	Primary Ciliary Dyskinesia 5 CILD5 Ciliary Dyskinesia, Primary, 5, Without Situs Inversus Primary Ciliary Dyskinesia 5 Without Situs Inversus Ics5 Immotile Cilia Syndrome 5 Primary Ciliary Dyskinesia 5 With Or Without Situs Inversus Dyskinesia, Ciliary, Primary, Type 5
Uterine Corpus Endometrial Carcinoma
Breast Mucoepidermoid Carcinoma	Mucoepidermoid Carcinoma Of Breast Mucoepidermoid Carcinoma Of The Breast
Hypertrophy Of Breast	Breasts Enlarged Large Breast Hypertrophy Of Breast Nos Hypertrophy Of Male Breast Hypertrophic Breast Excessive Development Of Breast Macromastia Mastoplastia
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Breast Lobular Carcinoma	Cancer, Breast, Lobular Lobular Breast Carcinoma
Persistent Mullerian Duct Syndrome	Persistent Müllerian Duct Syndrome Pmds Persistent Oviduct Syndrome Persistent Muellerian Duct Syndrome Female Genital Ducts In Otherwise Normal Male Hernia Uteri Inguinale Persistent Mullerian Duct Syndrome, Types 1 And 2 Persistent Mullerian Derivatives
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Disorder Of Sexual Development	Disorder Of Sex Development Disorders Of Sex Development Sex Development Disorder Sex Differentiation Disease Dsd Sex Differentiation Disorders
Cryptorchidism, Unilateral Or Bilateral	Cryptorchidism Undescended Testicle Undescended Testis Cryptorchism Undescended Testicles CRYPTO Impaired Testicular Descent Cryptosporidiosis Retained Testis Unilateral Cryptorchidism Unilateral Undescended Testis Nondescent Unilateral Testicle Unilateral Cryptorchism Ectopic Testis, Unilateral Bilateral Cryptorchidism Bilateral Cryptorchism Bilateral Nondescent Testicle Bilateral Undescended Testes Bilateral Ectopic Testes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-136848	SM1-71	Inhibitor	96.09%	Unkown
HY-Y1322	Triphenyl phosphate		99.67%	Unkown
HY-RS08046	MAP3K1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17349	Map3k1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23803	Map3k1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	MAP3K1	VGNC	VGNC:81458
Mus musculus	MAP3K1	MGD	MGI:1346872
Canis familiaris	MAP3K1	VGNC	VGNC:42966
Bos taurus	MAP3K1	VGNC	VGNC:31188
Rattus norvegicus	MAP3K1	RGD	RGD:620966
Felis catus	MAP3K1	VGNC	VGNC:97493
Others	MAP3K1	NCBI