MAP4K2 - mitogen-activated protein kinase kinase kinase kinase 2 Gene

Also Known as GCK; BL44; RAB8IP

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5871

About MAP4K2

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:64,784,918-64,803,214 (from NCBI)

This gene has 13 transcripts (splice variants), 101 orthologues and 35 paralogues. Broad expression in spleen (RPKM 10.3), lymph node (RPKM 8.4) and 24 other tissues.

Summary

The protein encoded by this gene is a member of the serine/threonine protein kinase family. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. This kinase can be activated by TNF-alpha, and has been shown to specifically activate MAP kinases. This kinase is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1/MEKK1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

MAP4K2 Products (2)

mRNA Protein Name
NM_001307990.2 NP_001294919.1 mitogen-activated protein kinase kinase kinase kinase 2 isoform 2
NM_004579.5 NP_004570.2 mitogen-activated protein kinase kinase kinase kinase 2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables ATP binding IDA
IDA: Inferred from direct assay
11784851 GOA
enables mitogen-activated protein kinase kinase kinase binding IPI
IPI: Inferred from physical interaction
17584736 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11784851 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
11784851 GOA
Biological Process GO Annotation Evidence References Source
involved in intracellular signal transduction IDA
IDA: Inferred from direct assay
11784851 GOA
involved in positive regulation of JNK cascade IDA
IDA: Inferred from direct assay
17584736 GOA
involved in positive regulation of JUN kinase activity IDA
IDA: Inferred from direct assay
17584736 GOA
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
11784851 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAP4K2 Protein Structure

Pkinase

Pkinase: Protein kinase domain (16 - 272)

CNH

CNH: CNH domain (492 - 789)

  • 0
  • 200
  • 400
  • 600
  • 820 a.a.
Protein Preferred Names Protein Names

mitogen-activated protein kinase kinase kinase kinase 2

  • B lymphocyte serine/threonine protein kinase

  • MAPK/ERK kinase kinase kinase 2

  • MEK kinase kinase 2

  • MEKKK 2

  • Rab8 interacting protein

  • germinal centre kinase (GC kinase)

MAP4K2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MAP4K2 Q12851 MAP3K1 Homo sapiens Q13233
Anti Bait CoIP
11784851
Intra
MAP4K2 Q12851 POT1 Homo sapiens Q9NUX5
Pull Down
21044950
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant MAP4K2 Proteins

Cat. No. Product Name Accession Purity
HY-P76946 MAP4K2 Protein, Human (sf9, His-GST) Q12851-2 (M1-Y812) ≥ 85%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Acute Kidney Failure

  • Acute Renal Failure

  • Renal Failure Acute

  • Acute Kidney Injury

  • Kidney Failure, Acute

  • Pre-Renal Acute Kidney Injury

  • Nontraumatic Acute Kidney Injury

  • Aki - [Acute Kidney Injury]

  • Arf - [Acute Kidney Failure]

  • Acute Kidney Disease

  • Acute Kidney Impairment

  • Acute Ischaemic Renal Failure

  • Acute Hypoxic Kidney Failure

  • Acute Kidney Shutdown

  • Acute Renal Oedema

  • Acute Renal Impairment

  • Acute Kidney Collapse

  • Acute Necrotising Kidney

  • Acute Renal Suppression
Cerebral Cavernous Malformations

  • Cerebral Cavernous Malformation

  • Cavernous Malformations Of Cns And Retina

  • Cerebral Cavernous Malformation 1

  • Cavernous Angiomatous Malformations

  • Cerebral Capillary Malformations

  • CCM

  • Hyperkeratotic Cutaneous Capillary-Venous Malformations Associated With Cerebral Capillary Malformations

  • Familial Cavernous Angioma

  • Familial Cerebral Cavernous Malformation

  • Cerebral Cavernous Malformations 1

  • Cavernous Angioma, Familial

  • Cam

  • Cerebral Cavernous Malformations-1

  • Cavernoma

  • Cavernous Angioma

  • Central Nervous System Cavernous Hemangioma

  • Cerebral Cavernous Hemangioma

  • Familial Cavernous Hemangioma

  • Familial Cavernous Malformation

  • Familial Cerebral Cavernous Angioma

  • Intracerebral Cavernous Hemangioma

  • CCM1

  • Cavernous Hemangioma Of The Brain

  • Cerebral Cavernoma

  • Cerebral Cavernous Malformations, Type 1

  • Hemangioma, Cavernous, Central Nervous System

  • Hemangioma, Cavernous

  • Angioma, Cavernous
Cerebral Cavernous Malformations 3

  • Cerebral Cavernous Malformation 3

  • CCM3

  • Cerebral Cavernous Malformations-3

  • Cavernous Angiomatous Malformations

  • Cavernous Hemangioma Of The Brain

  • Cerebral Capillary Malformations

  • Cerebral Cavernoma

  • Familial Cavernous Angioma

  • Cerebral Cavernous Malformations, Type 3
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (11)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15434 NG25 Inhibitor 98.68% Unkown
HY-148065 FMF-06-098-1 Inhibitor 98.77% Unkown
HY-77251 TAK1/MAP4K2 inhibitor 1 Inhibitor 99.91% Unkown
HY-123714 TL4-12 99.82% Unkown
HY-148061 DB1113 99.86% Unkown
HY-148063 DB0614 99.92% Unkown
HY-137343 DB-0646 Degrader 98.0% Unkown
HY-15434A NG25 trihydrochloride Inhibitor / Unkown
HY-RS08074 MAP4K2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08075 Map4k2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08076 Map4k2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta MAP4K2 VGNC VGNC:81465
Felis catus MAP4K2 VGNC VGNC:82021
Bos taurus MAP4K2 VGNC VGNC:31205
Canis familiaris MAP4K2 VGNC VGNC:42982
Mus musculus MAP4K2 MGD MGI:1346883
Rattus norvegicus MAP4K2 RGD RGD:1308199
Others MAP4K2 NCBI