MAP4K2 - mitogen-activated protein kinase kinase kinase kinase 2 Gene

Homo sapiens

Also known as GCK; BL44; RAB8IP

Gene ID: 5871 | Gene type: protein coding

About MAP4K2

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:64,784,918-64,803,214 (from NCBI)

This gene has 13 transcripts (splice variants), 101 orthologues and 35 paralogues. Broad expression in spleen (RPKM 10.3), lymph node (RPKM 8.4) and 24 other tissues.

Summary

The protein encoded by this gene is a member of the serine/threonine protein kinase family. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. This kinase can be activated by TNF-alpha, and has been shown to specifically activate MAP kinases. This kinase is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1/MEKK1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

MAP4K2 Products(2)

mRNA	Protein	Name
NM_001307990.2	NP_001294919.1	mitogen-activated protein kinase kinase kinase kinase 2 isoform 2
NM_004579.5	NP_004570.2	mitogen-activated protein kinase kinase kinase kinase 2 isoform 1

MAP4K2 Protein Structure

Pkinase

CNH

0
200
400
600
820 a.a.

Protein Preferred Names

Protein Names

mitogen-activated protein kinase kinase kinase kinase 2

B lymphocyte serine/threonine protein kinase	MAPK/ERK kinase kinase kinase 2
MEK kinase kinase 2	MEKKK 2
Rab8 interacting protein	germinal centre kinase (GC kinase)

Recombinant MAP4K2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76946	MAP4K2 Protein, Human (sf9, His-GST)	Q12851-2 (M1-Y812)	≥95%

Related Diseases

Diseases

Alias

Acute Kidney Failure

Acute Renal Failure	Renal Failure Acute
Acute Kidney Injury	Kidney Failure, Acute
Pre-Renal Acute Kidney Injury	Nontraumatic Acute Kidney Injury
Aki - [Acute Kidney Injury]	Arf - [Acute Kidney Failure]
Acute Kidney Disease	Acute Kidney Impairment
Acute Ischaemic Renal Failure	Acute Hypoxic Kidney Failure
Acute Kidney Shutdown	Acute Renal Oedema
Acute Renal Impairment	Acute Kidney Collapse
Acute Necrotising Kidney	Acute Renal Suppression

Cerebral Cavernous Malformations

Cerebral Cavernous Malformation	Cavernous Malformations Of Cns And Retina
Cerebral Cavernous Malformation 1	Cavernous Angiomatous Malformations
Cerebral Capillary Malformations	CCM
Hyperkeratotic Cutaneous Capillary-Venous Malformations Associated With Cerebral Capillary Malformations	Familial Cavernous Angioma
Familial Cerebral Cavernous Malformation	Cerebral Cavernous Malformations 1
Cavernous Angioma, Familial	Cam
Cerebral Cavernous Malformations-1	Cavernoma
Cavernous Angioma	Central Nervous System Cavernous Hemangioma
Cerebral Cavernous Hemangioma	Familial Cavernous Hemangioma
Familial Cavernous Malformation	Familial Cerebral Cavernous Angioma
Intracerebral Cavernous Hemangioma	CCM1
Cavernous Hemangioma Of The Brain	Cerebral Cavernoma
Cerebral Cavernous Malformations, Type 1	Hemangioma, Cavernous, Central Nervous System
Hemangioma, Cavernous	Angioma, Cavernous

Cerebral Cavernous Malformations 3

Cerebral Cavernous Malformation 3	CCM3
Cerebral Cavernous Malformations-3	Cavernous Angiomatous Malformations
Cavernous Hemangioma Of The Brain	Cerebral Capillary Malformations
Cerebral Cavernoma	Familial Cavernous Angioma
Cerebral Cavernous Malformations, Type 3

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15434	NG25	Inhibitor	99.35%	Unkown
HY-123714	TL4-12		99.82%	Unkown
HY-77251	TAK1/MAP4K2 inhibitor 1	Inhibitor	99.58%	Unkown
HY-148061	DB1113		99.28%	Unkown
HY-15434A	NG25 trihydrochloride	Inhibitor	/	Unkown
HY-148065	FMF-06-098-1		/	Unkown
HY-RS08074	MAP4K2 Human Pre-designed siRNA Set A		/	Unkown
HY-RS08075	Map4k2 Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS08076	Map4k2 Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	MAP4K2	VGNC	VGNC:81465
Felis catus	MAP4K2	VGNC	VGNC:82021
Bos taurus	MAP4K2	VGNC	VGNC:31205
Canis familiaris	MAP4K2	VGNC	VGNC:42982
Mus musculus	MAP4K2	MGD	MGI:1346883
Rattus norvegicus	MAP4K2	RGD	RGD:1308199
Others	MAP4K2	NCBI

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