1. MAPK/ERK Pathway
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    MAP3K
  3. TAK1/MAP4K2 inhibitor 1

TAK1/MAP4K2 inhibitor 1 

Cat. No.: HY-77251 Purity: 99.70%
Handling Instructions

TAK1/MAP4K2 inhibitor 1 is a potent dual TGFβ-activated kinase 1 (TAK1) and mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2) inhibitor, with IC50s of 41.1 nM and 18.2 nM, respectively.

For research use only. We do not sell to patients.

TAK1/MAP4K2 inhibitor 1 Chemical Structure

TAK1/MAP4K2 inhibitor 1 Chemical Structure

CAS No. : 1315330-11-0

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 450 In-stock
Estimated Time of Arrival: December 31
5 mg USD 370 In-stock
Estimated Time of Arrival: December 31
10 mg USD 475 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1280 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

TAK1/MAP4K2 inhibitor 1 is a potent dual TGFβ-activated kinase 1 (TAK1) and mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2) inhibitor, with IC50s of 41.1 nM and 18.2 nM, respectively.

IC50 & Target[1]

TAK1

41.1 nM (IC50)

MAP4K2

18.2 nM (IC50)

In Vivo

TAK1/MAP4K2 inhibitor 1 has moderate terminal elimination half-life (t1/2=2.94 h for mice (1 mg/kg, iv))[1].

Molecular Weight

552.59

Formula

C₂₉H₃₁F₃N₆O₂

CAS No.

1315330-11-0

SMILES

CC(N1)=CC2=C1N=CN=C2OC3=C(C)C=CC(C(NC4=CC=C(CN5CCN(CC)CC5)C(C(F)(F)F)=C4)=O)=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (90.48 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8097 mL 9.0483 mL 18.0966 mL
5 mM 0.3619 mL 1.8097 mL 3.6193 mL
10 mM 0.1810 mL 0.9048 mL 1.8097 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.75 mg/mL (4.98 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.75 mg/mL (4.98 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

TAK1/MAP4K2 inhibitor 1MAP4KMAP3KMAPK Kinase Kinase KinaseMAP kinase kinase kinase, MEKK, MAPKKKInhibitorinhibitorinhibit

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Product name:
TAK1/MAP4K2 inhibitor 1
Cat. No.:
HY-77251
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