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DYRK1B - dual specificity tyrosine phosphorylation regulated kinase 1B Gene

Also Known as MIRK; AOMS3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9149

About DYRK1B

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:39,825,350-39,834,162 (from NCBI)

This gene has 8 transcripts (splice variants), 1 gene allele, 189 orthologues, 12 paralogues and is associated with 2 phenotypes. Broad expression in testis (RPKM 21.5), prostate (RPKM 4.7) and 23 other tissues.

Summary

This gene encodes a member of a family of nuclear-localized protein kinases. The encoded protein participates in the regulation of the cell cycle. Expression of this gene may be altered in tumor cells, and mutations in this gene were found to cause abdominal obesity-metabolic syndrome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

DYRK1B Products (3)

mRNA	Protein	Name
NM_004714.3	NP_004705.1	dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform p69
NM_006483.3	NP_006474.1	dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform p65
NM_006484.3	NP_006475.1	dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform p66

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11980910	GOA
enables protein kinase activity	IDA IDA: Inferred from direct assay	11980910	GOA
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	11980910	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in adipose tissue development	IMP IMP: Inferred from mutant phenotype	24827035	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	11980910	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	11980910	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DYRK1B Protein Structure

Pkinase

0
100
200
300
400
500
600
629 a.a.

Protein Preferred Names	Protein Names
dual specificity tyrosine-phosphorylation-regulated kinase 1B	dual specificity tyrosine-(Y)-phosphorylation regulated kinase 1B

DYRK1B Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	DYRK1B	Q9Y463	GSC2	Homo sapiens	O15499	Y2H Array	32296183
Intra	DYRK1B	Q9Y463	GSC2	Homo sapiens	O15499	Y2H Prey Pooling	32296183
Intra	DYRK1B	Q9Y463	TROAP	Homo sapiens	Q12815	TAP	23602568
Intra	DYRK1B	Q9Y463	TROAP	Homo sapiens	Q12815	Pull Down	32707033
Intra	DYRK1B	Q9Y463	TROAP	Homo sapiens	Q12815	Anti Tag CoIP	23602568
Intra	DYRK1B	Q9Y463	HSP90AB1	Homo sapiens	P08238	Pull Down	32707033
Intra	DYRK1B	Q9Y463	YWHAE	Homo sapiens	P62258	Crosslink	36931259
Intra	DYRK1B	Q9Y463	DCAF7	Homo sapiens	P61962	TAP	23602568
Intra	DYRK1B	Q9Y463	DCAF7	Homo sapiens	P61962	Pull Down	32707033
Intra	DYRK1B	Q9Y463	RB1	Homo sapiens	P06400	Pull Down	32707033
Intra	DYRK1B	Q9Y463	RB1	Homo sapiens	P06400	Anti Tag CoIP	23602568
Intra	DYRK1B	Q9Y463	RB1	Homo sapiens	P06400	TAP	23602568
Intra	DYRK1B	Q9Y463	MAP2K3	Homo sapiens	P46734	Anti Bait CoIP	11980910
Intra	DYRK1B	Q9Y463	PCBD2	Homo sapiens	Q9H0N5	Y2H	11980910
Intra	DYRK1B	Q9Y463	PCBD2	Homo sapiens	Q9H0N5	Anti Bait CoIP	11980910
Intra	DYRK1B	Q9Y463	HNF1A	Homo sapiens	P20823	Pull Down	11980910
Intra	DYRK1B	Q9Y463	HNF1A	Homo sapiens	P20823	Protein Kinase Assay	11980910
Intra	DYRK1B	Q9Y463	RANBP9	Homo sapiens	Q96S59	Anti Bait CoIP	14500717
Intra	DYRK1B	Q9Y463	RANBP9	Homo sapiens	Q96S59	Anti Tag CoIP	14500717
Intra	DYRK1B	Q9Y463	RANBP9	Homo sapiens	Q96S59	Y2H	14500717
Intra	DYRK1B	Q9Y463	LZTS2	Homo sapiens	Q9BRK4	Pull Down	32707033
Intra	DYRK1B	Q9Y463	LZTS2	Homo sapiens	Q9BRK4	Anti Tag CoIP	23602568
Intra	DYRK1B	Q9Y463	LZTS2	Homo sapiens	Q9BRK4	TAP	23602568
Intra	DYRK1B	Q9Y463	RBL1	Homo sapiens	P28749	Anti Tag CoIP	23602568
Intra	DYRK1B	Q9Y463	RBL1	Homo sapiens	P28749	TAP	23602568
Intra	DYRK1B	Q9Y463	RBL1	Homo sapiens	P28749	Pull Down	32707033
Intra	DYRK1B	Q9Y463	RBL1	Homo sapiens	P28749	BiFC	23602568

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Abdominal Obesity-Metabolic Syndrome 3	AOMS3 Central Obesity, Type 2 Diabetes, Hypertension, And Early-Onset Coronary Artery Disease Obesity, Abdominal, Metabolic Syndrome, Type 3
Intellectual Developmental Disorder, Autosomal Dominant 7	MRD7 Mental Retardation, Autosomal Dominant 7 Autosomal Dominant Non-Syndromic Intellectual Disability 7 Dyrk1a Syndrome Autosomal Dominant Intellectual Developmental Disorder 7 Autosomal Dominant Mental Retardation 7 Mental Retardation, Autosomal Dominant, Type 7
Abdominal Obesity-Metabolic Syndrome Quantitative Trait Locus 2	Abdominal Obesity-Metabolic Syndrome Abdominal Obesity Metabolic Syndrome Metabolic Syndrome X Aoms2 Aoms1
Liver Rhabdomyosarcoma	Rhabdomyosarcoma Of Liver
Down Syndrome	Trisomy 21 Complete Trisomy 21 Syndrome Down'S Syndrome Trisomy 21 Syndrome Down'S Syndrome - Trisomy 21 Downs Syndrome G Trisomy 47,Xx,+21 47,Xy,+21 Trisomy G Down Syndrome, Susceptibility To Chromosome 21 Trisomy Trisomy 21 Nos Abnormal Autosomes 21
Rhabdomyosarcoma
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (27)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12277	AZ191	Inhibitor	99.98%	Unkown
HY-115470	CLK-IN-T3	Inhibitor	99.78%	Unkown
HY-108476	INDY	Inhibitor	99.32%	Unkown
HY-112296	T025		99.64%	Unkown
HY-111380	EHT 1610	Inhibitor	98.93%	Unkown
HY-12838	RO5454948	Inhibitor	99.53%	Unkown
HY-155723	Leucettinib-92	Inhibitor	98.54%	Unkown
HY-146221	Dyrk1A-IN-5	Inhibitor	98.06%	Unkown
HY-117391	AZ-Dyrk1B-33	Inhibitor	99.78%	Unkown
HY-111379	EHT 5372	Inhibitor	98.12%	Unkown
HY-128758A	DYRKs-IN-1 hydrochloride	Inhibitor	98.29%	Unkown
HY-128758	DYRKs-IN-1	Inhibitor	/	Unkown
HY-402805	DYRK2-IN-2	Inhibitor	/	Unkown
HY-402805A	DYRK2-IN-2 hydrochloride	Inhibitor	/	Unkown
HY-128759	DYRKs-IN-2	Inhibitor	/	Unkown
HY-144614	JH-XVII-10		/	Unkown
HY-144617	JH-XIV-68-3	Inhibitor	/	Unkown
HY-146337	Dyrk1A/B-IN-1	Inhibitor	/	Unkown
HY-175477	UNC9750	Inhibitor	/	Unkown
HY-177416	MU1787	Inhibitor	99.84%	Unkown
HY-RS04097	DYRK1B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-108475	ProINDY	Inhibitor	/	Unkown
HY-119607	DYRKi	Inhibitor	/	Unkown
HY-181085	RD0448	Inhibitor	/	Unkown
HY-77324S	4-(Trifluoromethyl)aniline-d4	Inhibitor	99.23%	Unkown
HY-RS17311	Dyrk1b Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23766	Dyrk1b Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	DYRK1B	VGNC	VGNC:61686
Bos taurus	DYRK1B	VGNC	VGNC:28280
Macaca mulatta	DYRK1B	VGNC	VGNC:72016
Canis familiaris	DYRK1B	VGNC	VGNC:40156
Rattus norvegicus	DYRK1B	RGD	RGD:1307223
Mus musculus	DYRK1B	MGD	MGI:1330302
Others	DYRK1B	NCBI