2. Protein Tyrosine Kinase/RTK Cell Cycle/DNA Damage Neuronal Signaling
  3. DYRK CDK Tau Protein
  4. DYRK2-IN-2 hydrochloride

DYRK2-IN-2 hydrochloride is a selective DYRK2 inhibitor with an IC50 of 40.3 nM. DYRK2-IN-2 hydrochloride shows weaker inhibitory activity against DYRK1A (IC50 = 1842 nM), DYRK1B (IC50 = 1335 nM), DYRK4 (IC50 = 1931 nM), DYRK3 (IC50 = 112 nM) and CLK (IC50 = 540-6496 nM). DYRK2-IN-2 hydrochloride inhibits the phosphorylation of Thr212 in Tau protein. DYRK2-IN-2 hydrochloride is applicable for neuronal research.

For research use only. We do not sell to patients.

DYRK2-IN-2 hydrochloride

DYRK2-IN-2 hydrochloride Chemical Structure

Size Price Stock Quantity
5 mg In-stock
10 mg In-stock
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 Customer Validation

Other Forms of DYRK2-IN-2 hydrochloride:

DYRK2-IN-2 hydrochloride Related Antibodies

Top Publications Citing Use of Products

View All DYRK Isoform Specific Products:

View All Isoforms
DYRK1 DYRK2 DYRK3 DYRK4 HIPK PRP4

View All CDK Isoform Specific Products:

View All Isoforms
CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85 CDK10 CDK15 CDK17 CDK18 CDK20 PITSLRE

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

DYRK2-IN-2 hydrochloride is a selective DYRK2 inhibitor with an IC50 of 40.3 nM. DYRK2-IN-2 hydrochloride shows weaker inhibitory activity against DYRK1A (IC50 = 1842 nM), DYRK1B (IC50 = 1335 nM), DYRK4 (IC50 = 1931 nM), DYRK3 (IC50 = 112 nM) and CLK (IC50 = 540-6496 nM). DYRK2-IN-2 hydrochloride inhibits the phosphorylation of Thr212 in Tau protein. DYRK2-IN-2 hydrochloride is applicable for neuronal research[1].

IC50 & Target[1]

DYRK2

40.3 nM (IC50)

DYRK1A

1842 nM (IC50)

DYRK1B

1335 nM (IC50)

DYRK4

1931 nM (IC50)

DYRK3

112 nM (IC50)

CLK1

1128 nM (IC50)

CLK2

4290 nM (IC50)

CLK3

6496 nM (IC50)

CLK4

536.9 nM (IC50)

In Vitro

DYRK2-IN-3 (Compound C17) (up to 10 μM) hydrochloride potently and selectively inhibits recombinant DYRK2 with an IC50 of 0.0403 μM; it shows weak activity against other kinases of the DYRK and CLK families, and no activity against CDK5/p25, CK1ε or GSK3β[1].
DYRK2-IN-3 (1-30 μM; 6 h) hydrochloride potently and dose-dependently inhibits Thr212-Tau phosphorylation in SH-SY5Y cells expressing 4R-Tau[1].
DYRK2-IN-3 (48 h) hydrochloride exhibits cytotoxicity against HT22 cells, with an IC50 of 14.7 μM following 48 h of exposure[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DYRK2-IN-2 hydrochloride Related Antibodies

Western Blot Analysis[1]

Cell Line: SH-SY5Y cells expressing human 4R-Tau
Concentration: 1-30 μM
Incubation Time: 6 h
Result: Efficiently and dose-dependently inhibited phosphorylation of Tau at the Thr212 site.
Induced a distinct second band in total Tau staining at the highest tested concentration.
Molecular Weight

420.95

Formula

C21H25ClN2O3S
Appearance

Solid

SMILES

COC1=CC2=C(SC[C@H]3CCNC3)C4=C(N=C2C=C1)C(CO)=CC(OC)=C4.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

DYRK2-IN-2 hydrochloride Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DYRK2-IN-2DYRKCDKTau ProteinDual specificity tyrosine phosphorylation regulated kinaseDual specificity tyrosine regulated kinaseCyclin dependent kinaseDYRK1BTauCLK family kinasesSH-SY5Y cellsDYRK1ADYRK34R-TauHT22 cellsDYRK2DYRK4Inhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
DYRK2-IN-2 hydrochloride
Cat. No.:
HY-402805A
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.