DYRKs-IN-2
DYRKs-IN-2 (Example 132) is a potent DYRKs inhibitor with IC50s of 30.6 nM and 12.8 nM for DYRK1B and DYRK1A, respectively. DYRKs-IN-2 has antitumor activity.
For research use only. We do not sell to patients.
- CAS No.: 1386980-04-6
- Formula: C32H38ClN9O3
- Molecular Weight:632.16
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 30.6 nM (DYRK1B) and 12.8 nM (DYRK1A)[2]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| SW-620 | EC50 |
0.18 μM
Compound: 27
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Cytotoxicity against human SW620 cells
Cytotoxicity against human SW620 cells
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[PMID: 24239188] |
DYRKs-IN-2 (Example 132) has an EC50 of 22.8 nM for SW620 cell line[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1386980-04-6
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Molecular Weight 632.16
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Formula C32H38ClN9O3
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SMILES
O=C(C1=CC2=CN=C(NCCCN3CCN(C)CC3)N=C2NC1=O)NC4=CC(C(NC(C5=CC=CC=C5)CCN)=O)=CC=C4Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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