RBL1 - RB transcriptional corepressor like 1 Gene

Homo sapiens

Also known as PRB1; p107; CP107

Gene ID: 5933 | Gene type: protein coding

About RBL1

Cytogenetic location: 20q11.23 Genomic coordinates (GRCh38): 20:36,996,349-37,095,997 (from NCBI)

This gene has 4 transcripts (splice variants), 194 orthologues and 2 paralogues. Ubiquitous expression in lymph node (RPKM 3.5), bone marrow (RPKM 2.8) and 25 other tissues.

Summary

The protein encoded by this gene is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and the product of this gene can form a complex with adenovirus E1A protein and SV40 large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is thought that the protein encoded by this gene may also be a tumor suppressor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

RBL1 Products(4)

mRNA	Protein	Name
NM_001323281.2	NP_001310210.1	retinoblastoma-like protein 1 isoform c
NM_001323282.2	NP_001310211.1	retinoblastoma-like protein 1 isoform c
NM_002895.5	NP_002886.2	retinoblastoma-like protein 1 isoform a
NM_183404.4	NP_899662.1	retinoblastoma-like protein 1 isoform b

RBL1 Protein Structure

DUF3452

RB_A

RB_B

Rb_C

0
200
400
600
800
1000
1068 a.a.

Protein Preferred Names

Protein Names

retinoblastoma-like protein 1

107 kDa retinoblastoma-associated protein

Related Diseases

Diseases

Alias

Retinoblastoma

RB	Trilateral Retinoblastoma
RB1	Retinoblastoma, Trilateral
Neuroblastoma Of Retina	Rb - Retinoblastoma
Eye Cancer, Retinoblastoma	Retinal Cancer
Retinal Tumor	Glioma, Retinal
Non-Hereditary Retinoblastoma	Childhood Cancer Retinoblastoma
Malignant Neoplasm Of Retina	Retinal Neoplasms

Bilateral Retinoblastoma

Retinal Cancer

Malignant Neoplasm Of Retina	Retinal Neoplasms
Malignant Retinal Neoplasm	Malignant Tumor Of Retina
Neoplasm Of Retina	Retinal Tumor
Retinal Neoplasm	Cancer Of The Retina
Malignant Retinal Tumour	Malignant Tumour Of Retina
Primary Malignant Neoplasm Of Retina

Cecal Benign Neoplasm

Cecal Neoplasms	Cecum Neoplasm
Neoplasm Of Caecum	Cecal Neoplasm
Cecum Carcinoma	Malignant Neoplasm Of Cecum

Cecum Adenoma

Caecum Adenoma

Papilloma

Papillomatosis

Familial Retinoblastoma

Hereditary Retinoblastoma

Retinoblastoma

Unilateral Retinoblastoma

Ocular Cancer

Eye Neoplasm	Eye Carcinoma
Eye Cancer	Eye Neoplasms
Malignant Eye Neoplasm	Neoplasm Of Eye
Neoplasm Of Eye Proper	Ocular Tumor
Carcinoma Of Eye	Ocular Carcinoma
Malignant Tumor Of Eye

Intraocular Retinoblastoma

Pediatric Intraocular Retinoblastoma

Focal Epithelial Hyperplasia

Heck'S Disease	Heck Disease
Multifocal Epithelial Hyperplasia

Retinal Disease

Retinal Diseases	Retinal Disorder
Retinal Disorders

Osteogenic Sarcoma

Osteosarcoma	OSRC
Osteosarcoma, Somatic	Neoplasms, Bone Tissue
Bone Tissue Neoplasm	Osteoid Sarcoma
Skeletal Sarcoma	Osteosarcoma Of Bone
Bone Sarcoma

Epidermodysplasia Verruciformis 1

Epidermodysplasia Verruciformis	Epidermodysplasia Verruciformis, Susceptibility To, 1
Lutz-Lewandowsky Epidermodysplasia Verruciformis	EV1
Lewandowsky-Lutz Syndrome	Ev

Sensory System Disease

Eye Disease

Eye Diseases	Abnormality Of The Eye
Toxoplasma Oculopathy

Nervous System Disease

Abnormality Of The Nervous System	Nervous System Diseases
Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-105024	FPL 62064	Inhibitor	98.46%	Unkown
HY-RS11729	RBL1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	RBL1	VGNC	VGNC:69260
Bos taurus	RBL1	VGNC	VGNC:33781
Rattus norvegicus	RBL1	RGD	RGD:1595511
Mus musculus	RBL1	MGD	MGI:103300
Macaca mulatta	RBL1	VGNC	VGNC:76679
Canis familiaris	RBL1	VGNC	VGNC:45402

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