1. Protein Tyrosine Kinase/RTK
  2. DYRK
  3. INDY

INDY 

Cat. No.: HY-108476
Handling Instructions

INDY is a potent and ATP-competitive Dyrk1A and Dyrk1B inhibitor with IC50s of 0.24 μM and 0.23 μM, respectively. INDY binds in the ATP pocket of the enzyme and has a Ki value of 0.18 μM for Dyrk1A. INDY sharply reduces the self-renewal capacity of normal and tumorigenic cells in primary Glioblastoma (GBM) cell lines and neural progenitor cells.

For research use only. We do not sell to patients.

INDY Chemical Structure

INDY Chemical Structure

CAS No. : 1169755-45-6

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Description

INDY is a potent and ATP-competitive Dyrk1A and Dyrk1B inhibitor with IC50s of 0.24 μM and 0.23 μM, respectively. INDY binds in the ATP pocket of the enzyme and has a Ki value of 0.18 μM for Dyrk1A. INDY sharply reduces the self-renewal capacity of normal and tumorigenic cells in primary Glioblastoma (GBM) cell lines and neural progenitor cells[1][2].

IC50 & Target

IC50: 0.24 μM (Dyrk1A) and 0.23 μM (Dyrk1B)[1]
Ki: 0.18 μM (Dyrk1A)[1]

In Vitro

INDY (0.3-30 μM; 20 hours) mildly inhibits tau-phosphorylation at 3 μM, and nearly completely inhibits at 30 μM[1].
INDY effectively reverses the aberrant tau-phosphorylation and rescues the repressed NFAT (nuclear factor of activated T cell) signalling induced by Dyrk1A (dual-specificity tyrosine-(Y)-phosphorylation-regulated kinase 1A) overexpression[1].

Western Blot Analysis[1]

Cell Line: COS7 cells transfected with either EGFP-Dyrk1A and EGFP-tau
Concentration: 0.3, 1, 3, 10, 30 μM
Incubation Time: 20 hours
Result: Mildly inhibited tau-phosphorylation at 3 μM, and nearly completely inhibited at 30 μM.
In Vivo

ProINDY (2.5 μM) recoveres apparently normal development of the Xenopus embryo[1].

Molecular Weight

235.30

Formula

C₁₂H₁₃NO₂S

CAS No.

1169755-45-6

SMILES

CC(/C=C1SC2=CC=C(O)C=C2N\1CC)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

INDYDYRKDual specificity tyrosine phosphorylation regulated kinaseDual specificity tyrosine regulated kinaseATP-competitiveDyrk1ADyrk1Bself-renewalcapacitytumorigenicGlioblastomaGBMneuralprogenitorInhibitorinhibitorinhibit

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