MU1787 

MU1787 is a highly selective homeodomain-interacting protein kinase (HIPK) inhibitor with a furopyridine core, and shows improved selectivity against CLKs, with inactivity against DYRK1B, DYRK2, and MLK2/3 in in vitro cellular assays. MU1787 can be used for the research of malignancies^[1].

MU1787 potently inhibits purified human HIPK1 (IC₅₀=187 nM), HIPK2 (IC₅₀=29 nM), HIPK3 (IC₅₀=159 nM), DYRK1A (IC₅₀=213 nM), DYRK1B (IC₅₀=956 nM), DYRK2 (IC₅₀=1309 nM), CLK1 (IC₅₀=8 nM), CLK2 (IC₅₀=20 nM), and CLK4 (IC₅₀=12 nM), but shows no significant inhibitory activity against CLK3^[1].
MU1787 (10 μM) exhibits high selectivity for human HIPK1, HIPK2 and HIPK3 in a screening panel containing 373 purified kinases, only partially inhibits HIPK4 (51%), and shows extremely low off-target activity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

318.37

C₁₉H₁₈N₄O

2624098-97-9

CC(C)(C)C1=CC=C(C=C1)C2=COC(C=C3)=C2N=C3C4=CN=NN4

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Němec V, et al. Highly selective inhibitors of protein kinases CLK and HIPK with the furo [3, 2-b] pyridine core[J]. European Journal of Medicinal Chemistry, 2021, 215: 113299.