HIPK1
HIPK1, also referred to as DYRK6, is a nuclear kinase of the HIPK branch of the DYRK family. Its domain organization explains both its name and its function: the catalytic domain is followed by a homeodomain-interacting region that tethers it to homeodomain transcription factors, plus a CtBP-binding domain that recruits the transcriptional corepressor CtBP. Through these interactions HIPK1 modulates transcription-factor activity, Wnt-type signaling, and apoptosis. Expression is highest in testis and detectable across a range of somatic tissues. HIPK1 is less well characterized than HIPK2 but shares its activation-loop tyrosine autophosphorylation mechanism. The recombinant kinase supports studies of transcriptional repression and kinase-partner interactions.
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HIPK1 Recombinant Proteins (2)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
