CLK1
Of the four CDC-like kinases, CLK1 is the best-characterized splicing regulator and one of the most abundant, with particularly high expression in brain and heart. A dual-specificity enzyme, it phosphorylates its own activation-loop tyrosine and then transfers phosphate to serine residues in the RS domains of SR proteins such as SRSF1, controlling their localization to nuclear speckles and the choice of alternative exons. Through these substrates CLK1 influences circadian period, viral replication, and cell proliferation. Small molecules including TG003-type inhibitors have made CLK1 a probe target for splicing modulation in oncology. Recombinant CLK1 supports enzymatic assays, substrate studies, and inhibitor selectivity work.
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CLK1 Recombinant Proteins (1)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
