MAP2K3 - mitogen-activated protein kinase kinase 3 Gene

Also Known as MEK3; MKK3; MAPKK3; PRKMK3; SAPKK2; SAPKK-2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5606

About MAP2K3

Cytogenetic location: 17p11.2 Genomic coordinates (GRCh38): 17:21,284,711-21,315,240 (from NCBI)

This gene has 15 transcripts (splice variants), 133 orthologues and 35 paralogues. Ubiquitous expression in bone marrow (RPKM 62.9), gall bladder (RPKM 18.4) and 23 other tissues.

Summary

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by Insulin, and is necessary for the expression of glucose transporter. Expression of Ras oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008]

MAP2K3 Products (3)

mRNA Protein Name
NM_001316332.2 NP_001303261.1 dual specificity mitogen-activated protein kinase kinase 3 isoform A
NM_002756.4 NP_002747.2 dual specificity mitogen-activated protein kinase kinase 3 isoform A
NM_145109.3 NP_659731.1 dual specificity mitogen-activated protein kinase kinase 3 isoform B

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables MAP kinase kinase activity IDA
IDA: Inferred from direct assay
8622669 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11980910 GOA
enables protein kinase binding IPI
IPI: Inferred from physical interaction
11279118 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to vascular endothelial growth factor stimulus IMP
IMP: Inferred from mutant phenotype
22696064 GOA
involved in negative regulation of hippo signaling IMP
IMP: Inferred from mutant phenotype
27402810 GOA
involved in p38MAPK cascade IMP
IMP: Inferred from mutant phenotype
22696064 GOA
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
11980910 GOA
involved in positive regulation of blood vessel endothelial cell migration IMP
IMP: Inferred from mutant phenotype
22696064 GOA
involved in positive regulation of protein kinase activity IDA
IDA: Inferred from direct assay
11980910 GOA
involved in stress-activated protein kinase signaling cascade IDA
IDA: Inferred from direct assay
8622669 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAP2K3 Protein Structure

Pkinase

Pkinase: Protein kinase domain (66 - 325)

  • 0
  • 100
  • 200
  • 300
  • 347 a.a.
Protein Preferred Names Protein Names

dual specificity mitogen-activated protein kinase kinase 3

  • MAP kinase kinase 3

MAP2K3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MAP2K3 P46734 MAP3K5 Homo sapiens Q99683
Anti Bait CoIP
19805025
Intra
MAP2K3 P46734 MAP3K5 Homo sapiens Q99683
Anti Tag CoIP
31980649
Intra
MAP2K3 P46734 LRRK2 Homo sapiens Q5S007
Anti Tag CoIP
20067578
Intra
MAP2K3 P46734 DYRK1B Homo sapiens Q9Y463
Protein Kinase Assay
11980910
Intra
MAP2K3 P46734 TINF2 Homo sapiens Q9BSI4
BiFC
21044950
Intra
MAP2K3 P46734 TINF2 Homo sapiens Q9BSI4
Pull Down
21044950
Intra
MAP2K3 P46734 MAPK14 Homo sapiens Q16539
Anti Tag CoIP
31980649
Cross: Cross-species interaction Intra: Intraspecies interaction

MAP2K3 Antibodies

Cat. No. Product Name Application Reactivity
HY-P810590 Phospho-MEK3 (Ser189)+MEK6 (Ser207) Antibody (YA9854) WB Human, Mouse
HY-P83469 MEK3 Antibody (YA3214) WB, ICC/IF, IP Human, Mouse, Rat
HY-P83469A MEK3 Antibody (YA3214)(PBS only) WB, ICC/IF, IP Human, Mouse, Rat
HY-P83578 MEK3+MEK6 Antibody (YA3323) WB, IHC-P, ICC/IF, IP, FC Human, Mouse, Rat
HY-P83578A MEK3+MEK6 Antibody (YA3323)(PBS only) WB, IHC-P, ICC/IF, IP, FC Human, Mouse, Rat
HY-P84341 MEK3 Antibody (YA4038) IHC-P, ICC/IF, FC, ELISA Human
HY-P84341A MEK3 Antibody (YA4038)(PBS only) IHC-P, ICC/IF, FC, ELISA Human
HY-P86356 MEK3 Antibody (YA6048) WB, IHC-P, ICC/IF, IP, ELISA Human, Mouse, Rat

Related Diseases

Diseases Alias
Inhalation Anthrax

  • Pulmonary Anthrax

  • Respiratory Anthrax

  • Inhalational Anthrax

  • Wool-Sorters' Disease

  • Woolsorters' Disease

  • Inhalation Anthrax Disease

  • Respiratory Anthrax Disease
Cutaneous Anthrax

  • Anthrax, Skin Type

  • Skin Anthrax
Pulmonary Systemic Sclerosis

  • Lung Disease With Systemic Sclerosis

  • Lung Involvement In Systemic Sclerosis
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Cardiomyopathy, Familial Hypertrophic, 25

  • Hypertrophic Cardiomyopathy 25

  • CMH25

  • Cardiomyopathy, Hypertrophic, 25

  • Cardiomyopathy Familial Hypertrophic 25

  • Cardiomyopathy, Familial Hypertrophic 25

  • Cardiomyopathy, Hypertrophic, Type 25
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08039 MAP2K3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus MAP2K3 VGNC VGNC:97491
Macaca mulatta MAP2K3 VGNC VGNC:81454
Mus musculus MAP2K3 MGD MGI:1346868
Canis familiaris MAP2K3 VGNC VGNC:42961
Rattus norvegicus MAP2K3 RGD RGD:1306620
Bos taurus MAP2K3 VGNC VGNC:31184
Others MAP2K3 NCBI