country

Change Language

Country or Region:

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-P84341A

MEK3 Antibody (YA4038)(PBS only)

Name: MEK3 Antibody (YA4038)(PBS only)
Brand: MedChemExpress
SKU: HY-P84341A
Availability: PreOrder

(Synonyms: MEK3; MKK3; MAPKK3; PRKMK3; SAPKK2; SAPKK-2)

MEK3 Antibody (YA4038) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to MEK3.

For research use only. We do not sell to patients.

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Applications

Application	IHC-P IHC-P: Immunohistochemistry-Paraffin	ICC/IF ICC/IF: Immunocytochemistry/ Immunofluorescence	FC FC: Flow Cytometry	ELISA ELISA: Enzyme Linked Immunosorbent Assay
Dilution Ratio	1:200-1:1000	1:200-1:1000	1:200-1:400	1:10000

Description

MEK3 Antibody (YA4038) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to MEK3.

Host Mouse
Species Reactivity
Human
Observed Molecular Weight

Observed band size: 38-40 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Calculated Molecular Weight Predicted band size: 39 kDa

Immunogen

Purified recombinant fragment of human MAP2K3 (AA: 1-138) expressed in E. Coli.

Purification

affinity purified.

Conjugation

Non-conjugated

Isotype

IgG1

Appearance

Liquid
Formulation

Supplied in PBS, pH 7.4.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.

Function

MEK3 dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14
Expression

Tissue_specificity:This gene is highly expressed in skeletal muscle and is also widely expressed in other tissues.
Isoforms & Post-Translational Modification

P46734 has 3 isomers: P46734-1: 39318 Da (predicted); P46734-2: 36173 Da (predicted); P46734-3: 39940 Da (predicted).
Autophosphorylated. Phosphorylation on Ser-218 and Thr-222 by MAP kinase kinase kinases positively regulates the kinase activity (PubMed:8622669). Phosphorylated by TAOK2 (PubMed:11279118);(Microbial infection) Yersinia YopJ may acetylate Ser/Thr residues, preventing phosphorylation and activation, thus blocking the MAPK signaling pathway
Subunit

Component of a signaling complex containing at least AKAP13, PKN1, MAPK14, ZAK and MAP2K3. Within this complex, AKAP13 interacts directly with PKN1, which in turn recruits MAPK14, MAP2K3 and ZAK (PubMed:21224381). Binds to DYRK1B/MIRK and increases its kinase activity (PubMed:11980910). Part of a complex with MAP3K3, RAC1 and CCM2 (By similarity). Interacts with ARRB1 (PubMed:16709866)
SwissProt ID

P46734
Gene ID

5606 [NCBI]
Synonyms

MEK3; MKK3; MAPKK3; PRKMK3; SAPKK2; SAPKK-2