1. Cell Cycle/DNA Damage
    Stem Cell/Wnt
    MAPK/ERK Pathway
    JAK/STAT Signaling
    Protein Tyrosine Kinase/RTK
    Apoptosis
  2. Casein Kinase
    ERK
    Pim
    DYRK
    Apoptosis
  3. CK2/ERK8-IN-1

CK2/ERK8-IN-1 

Cat. No.: HY-135906 Purity: >99.0%
Handling Instructions

CK2/ERK8-IN-1 is a dual casein kinase 2 (CK2) (Ki of 0.25 µM) and ERK8 inhibitor with IC50s of 0.50 μM. CK2/ERK8-IN-1 also binds to PIM1, HIPK2 (homeodomain-interacting protein kinase 2), and DYRK1A with Kis of 8.65 µM, 15.25 µM, and 11.9 µM, respectively. CK2/ERK8-IN-1 has pro-apoptotic efficacy.

For research use only. We do not sell to patients.

CK2/ERK8-IN-1 Chemical Structure

CK2/ERK8-IN-1 Chemical Structure

CAS No. : 1085822-09-8

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Description

CK2/ERK8-IN-1 is a dual casein kinase 2 (CK2) (Ki of 0.25 µM) and ERK8 inhibitor with IC50s of 0.50 μM. CK2/ERK8-IN-1 also binds to PIM1, HIPK2 (homeodomain-interacting protein kinase 2), and DYRK1A with Kis of 8.65 µM, 15.25 µM, and 11.9 µM, respectively. CK2/ERK8-IN-1 has pro-apoptotic efficacy[1].

IC50 & Target[1]

CK2

0.5 μM (IC50)

CK2

0.25 μM (Ki)

ERK8

0.5 μM (IC50)

PIM1

8.65 μM (Ki)

HIPK2

15.25 μM (Ki)

DYRK1A

11.9 μM (Ki)

Apoptosis

 

In Vitro

CK2/ERK8-IN-1 (Compound K66; 0-50 µM; 24 hours; Jurkat cells) treatment displays cytotoxic activity in Jurkat cells[1].

Cell Viability Assay[1]

Cell Line: Jurkat cells
Concentration: 0-50 µM
Incubation Time: 24 hours
Result: Inhibited cell growth in a dose-dependent manner.
Molecular Weight

534.82

Formula

C₁₁H₉Br₄N₃O₂

CAS No.

1085822-09-8

SMILES

O=C(O)CN1C2=C(Br)C(Br)=C(Br)C(Br)=C2N=C1N(C)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >99.0%

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Keywords:

CK2/ERK8-IN-1Casein KinaseERKPimDYRKApoptosisExtracellular signal regulated kinasesPim kinasesDual specificity tyrosine phosphorylation regulated kinaseDual specificity tyrosine regulated kinaseCK2ERK8PIM1HIPK2DYRK1Acytotoxicbenzimidazolepro-apoptoticInhibitorinhibitorinhibit

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CK2/ERK8-IN-1
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