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RPS16 - ribosomal protein S16 Gene

Also Known as S16

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6217

About RPS16

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:39,433,137-39,435,949 (from NCBI)

This gene has 8 transcripts (splice variants), 240 orthologues and 1 paralogue. Ubiquitous expression in ovary (RPKM 933.9), lymph node (RPKM 484.0) and 25 other tissues.

Summary

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S9P family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

RPS16 Products (3)

mRNA	Protein	Name
NM_001020.6	NP_001011.1	40S ribosomal protein S16 isoform 1
NM_001321111.2	NP_001308040.1	40S ribosomal protein S16 isoform 2
NM_001363860.2	NP_001350789.1	40S ribosomal protein S16 isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables RNA binding	IDA IDA: Inferred from direct assay	17881366	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	24725412	GOA
enables structural constituent of ribosome	IDA IDA: Inferred from direct assay	23636399	GOA
enables structural constituent of ribosome	IMP IMP: Inferred from mutant phenotype	18697920	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in rRNA processing	IMP IMP: Inferred from mutant phenotype	18697920	GOA
involved in ribosomal small subunit biogenesis	IDA IDA: Inferred from direct assay	34516797	GOA
involved in ribosomal small subunit biogenesis	IMP IMP: Inferred from mutant phenotype	18697920	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytosolic ribosome	IDA IDA: Inferred from direct assay	23636399	GOA
part of cytosolic small ribosomal subunit	IDA IDA: Inferred from direct assay	8706699	GOA
part of small-subunit processome	IDA IDA: Inferred from direct assay	34516797	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPS16 Protein Structure

Ribosomal_S9

0
100
146 a.a.

Protein Preferred Names	Protein Names
40S ribosomal protein S16	small ribosomal subunit protein uS9

RPS16 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RPS16	P62249	RPS19	Homo sapiens	P39019	Anti Tag CoIP	35271311
Intra	RPS16	P62249	RPS19	Homo sapiens	P39019	Anti Tag CoIP	33961781
Intra	RPS16	P62249	LRRK2	Homo sapiens	Q5S007	Protein Kinase Assay	24725412

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Influenza	Flu Influenza With Non-Respiratory Manifestation Influenza With Other Manifestations Influenza, Human Influenza, Susceptibility To Seasonal Influenza, Virus Identified
Diamond-Blackfan Anemia	Congenital Pure Red Cell Aplasia Aase Syndrome Erythrogenesis Imperfecta Anemia, Diamond-Blackfan Congenital Hypoplastic Anemia Aase-Smith Ii Syndrome Bds Blackfan-Diamond Anemia Congenital Prca Congenital Hypoplastic Anemia, Blackfan-Diamond Type Dba Blackfan - Diamond Syndrome Chronic Constitutional Pure Red Cell Anaemia Anemia Diamond Blackfan Type Anemia Congenital Erythroid Hypoplastic Aregenerative Anemia Chronic Congenital Blackfan Diamond Syndrome Red Cell Aplasia, Pure Hereditary Aase-Smith Syndrome Ii Bda Blackfan Diamond Anemia Blackfan-Diamond Disease Blackfan-Diamond Syndrome Chronic Congenital Agenerative Anemia Congenital Erythroid Hypoplastic Anemia Congenital Hypoplastic Anemia Of Blackfan And Diamond Congenital Pure Red Cell Anemia Hypoplastic Congenital Anemia Inherited Erythroblastopenia Pure Hereditary Red Cell Aplasia Anemia, Hypoplastic, Congenital Anemia Hypoplastic Congenital Fanconi Anemia Constitutional Aplastic Anemia Diamond-Blackfan Anemia 1 Aase Smith Syndrome 2 Congenital Red Cell Aplasia Red Cell Aplasia Of Infants Pure Red Cell Aplasia Of Infants Congenital Red Cell Aplastic Anaemia Congenital Pure Red Cell Anaemia Congenital Erythroid Hypoplasia Pearson Marrow-Pancreas Syndrome
Spherocytosis, Type 4	Hereditary Spherocytosis Type 4 SPH4 Hs4 Spherocytosis, Hereditary, 4 Hereditary Spherocytosis 4 Spherocytosis 4
Carbuncle	Carbuncle And Furuncle Of Any Part Of Face Except Eye Carbuncle And Furuncle Of Buttock Carbuncle And Furuncle Of Face Carbuncle And Furuncle Of Foot Carbuncle And Furuncle Of Gluteal Region Carbuncle And Furuncle Of Hand Carbuncle And Furuncle Of Leg Except Foot Carbuncle And Furuncle Of Neck Carbuncle And Furuncle Of Trunk Carbuncle And Furuncle Of Upper Arm And Forearm
Autoimmune Lymphoproliferative Syndrome	ALPS Canale-Smith Syndrome Autoimmune Lymphoproliferative Syndrome, Type Ia Autoimmune Lymphoproliferative Syndrome, Type Ib Autoimmune Lymphoproliferative Syndrome Type 1, Autosomal Dominant Css Autoimmune Lymphoproliferative Syndrome, Type 1b Autoimmune Lymphoproliferative Syndrome, Type 1a Autoimmune Lymphoproliferative Syndrome, Type I, Autosomal Dominant Fas Deficiency Autoimmune Lymphoproliferative Syndrome 1a ALPS1A Autoimmune Lymphoproliferative Syndrome Type Ia Autoimmune Lymphoproliferative Syndrome 1b ALPS1B Autoimmune Lymphoproliferative Syndrome Type Ib
Peroxisome Biogenesis Disorder 1b	Peroxisome Biogenesis Disorder Infantile Refsum Disease Infantile Phytanic Acid Storage Disease PBD1B Refsum Disease, Infantile Adrenoleukodystrophy, Autosomal Neonatal Ird Mild Pbd-Zsd Mild Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder Pbd-Zsd Peroxisome Biogenesis Disorder Spectrum Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder Autosomal Neonatal Adrenoleukodystrophy Refsum Disease Infantile Peroxisome Biogenesis Disorders Peroxisome Biogenesis Disorder, Type 1b

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12227	RPS16 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	RPS16	VGNC	VGNC:103748
Mus musculus	RPS16	MGD	MGI:98118
Rattus norvegicus	RPS16	RGD	RGD:621031
Canis familiaris	RPS16	VGNC	VGNC:45732
Others	RPS16	NCBI