RAB38 - RAB38, member RAS oncogene family Gene

Also Known as rrGTPbp; NY-MEL-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23682

About RAB38

Cytogenetic location: 11q14.2 Genomic coordinates (GRCh38): 11:87,803,715-88,175,443 (from NCBI)

This gene has 3 transcripts (splice variants), 267 orthologues and 68 paralogues. Biased expression in skin (RPKM 6.0), esophagus (RPKM 5.8) and 13 other tissues.

Summary

Enables several functions, including AP-1 adaptor complex binding activity; AP-3 adaptor complex binding activity; and BLOC-2 complex binding activity. Involved in several processes, including endosome to melanosome transport; melanosome assembly; and phagosome acidification. Located in several cellular components, including cytoplasmic vesicle; lysosome; and mitochondria-associated endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]

RAB38 Products (1)

mRNA	Protein	Name
NM_022337.3	NP_071732.1	ras-related protein Rab-38

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables AP-1 adaptor complex binding	IPI IPI: Inferred from physical interaction	22511774	GOA
NOT enables AP-2 adaptor complex binding	IDA IDA: Inferred from direct assay	22511774	GOA
enables AP-3 adaptor complex binding	IPI IPI: Inferred from physical interaction	22511774	GOA
enables BLOC-2 complex binding	IPI IPI: Inferred from physical interaction	22511774	GOA
enables GTP-dependent protein binding	IPI IPI: Inferred from physical interaction	22511774	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	22511774	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in endosome to melanosome transport	IMP IMP: Inferred from mutant phenotype	22511774	GOA
involved in melanosome assembly	IDA IDA: Inferred from direct assay	23084991	GOA
involved in melanosome assembly	IMP IMP: Inferred from mutant phenotype	22511774	GOA
involved in mitochondrion organization	IMP IMP: Inferred from mutant phenotype	25767741	GOA
involved in phagosome acidification	IMP IMP: Inferred from mutant phenotype	21255211	GOA
involved in protein localization to membrane	IMP IMP: Inferred from mutant phenotype	22511774	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in early endosome	IDA IDA: Inferred from direct assay	22511774	GOA
NOT located in early endosome lumen	IDA IDA: Inferred from direct assay	22511774	GOA
located in lysosome	IDA IDA: Inferred from direct assay	25767741	GOA
located in melanosome	IDA IDA: Inferred from direct assay	22511774	GOA
located in melanosome membrane	IDA IDA: Inferred from direct assay	23084991	GOA
located in membrane	IDA IDA: Inferred from direct assay	22511774	GOA
located in mitochondria-associated endoplasmic reticulum membrane contact site	IDA IDA: Inferred from direct assay	25767741	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	25767741	GOA
located in phagocytic vesicle	IDA IDA: Inferred from direct assay	21255211	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAB38 Protein Structure

Ras

0
100
200
211 a.a.

Protein Preferred Names	Protein Names
ras-related protein Rab-38	Rab-related GTP-binding protein

RAB38 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RAB38	P57729	JPH3	Homo sapiens	Q8WXH2	Validated Y2H	32814053
Intra	RAB38	P57729	JPH3	Homo sapiens	Q8WXH2	Y2H Array	32814053
Intra	RAB38	P57729	JPH3	Homo sapiens	Q8WXH2	Y2H Pooling	32814053
Intra	RAB38	P57729	DNM2	Homo sapiens	P50570-2	Y2H Array	32814053
Intra	RAB38	P57729	DNM2	Homo sapiens	P50570-2	Y2H Pooling	32814053
Intra	RAB38	P57729	DNM2	Homo sapiens	P50570-2	Validated Y2H	32814053
Intra	RAB38	P57729	MECP2	Homo sapiens	P51608	Y2H Array	32814053
Intra	RAB38	P57729	MECP2	Homo sapiens	P51608	Validated Y2H	32814053
Intra	RAB38	P57729	MECP2	Homo sapiens	P51608	Y2H Pooling	32814053
Intra	RAB38	P57729	TOR1A	Homo sapiens	O14656-2	Validated Y2H	32814053
Intra	RAB38	P57729	TOR1A	Homo sapiens	O14656-2	Y2H Array	32814053
Intra	RAB38	P57729	TOR1A	Homo sapiens	O14656-2	Y2H Pooling	32814053
Intra	RAB38	P57729	SMN1	Homo sapiens	Q16637	Y2H Array	32814053
Intra	RAB38	P57729	SMN1	Homo sapiens	Q16637	Y2H Pooling	32814053
Intra	RAB38	P57729	SMN1	Homo sapiens	Q16637	Validated Y2H	32814053
Intra	RAB38	P57729	LRRK2	Homo sapiens	Q5S007	FPS	31552791
Intra	RAB38	P57729	LRRK2	Homo sapiens	Q5S007	Pull Down	31552791
Intra	RAB38	P57729	A2M	Homo sapiens	P01023	Validated Y2H	32814053
Intra	RAB38	P57729	A2M	Homo sapiens	P01023	Y2H Pooling	32814053
Intra	RAB38	P57729	A2M	Homo sapiens	P01023	Y2H Array	32814053
Intra	RAB38	P57729	NDUFV2	Homo sapiens	P19404	Validated Y2H	32814053
Intra	RAB38	P57729	NDUFV2	Homo sapiens	P19404	Y2H Array	32814053
Intra	RAB38	P57729	NDUFV2	Homo sapiens	P19404	Y2H Pooling	32814053
Intra	RAB38	P57729	GFAP	Homo sapiens	P14136	Y2H Array	32814053
Intra	RAB38	P57729	GFAP	Homo sapiens	P14136	Y2H Pooling	32814053
Intra	RAB38	P57729	GFAP	Homo sapiens	P14136	Validated Y2H	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

RAB38 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P810259	Rab 38 Antibody (YA9603)	WB, ICC/IF, IF-Tissue, IP, ELISA	human, mouse, rat
HY-P810980	RAB38 Antibody	WB, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Oculocutaneous Albinism	Albinism, Oculocutaneous Oca Albinism Oculocutaneous Oca - [Oculocutaneous Albinism]
Hermansky-Pudlak Syndrome	Hps Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells Hermanski-Pudlak Syndrome Hermansky Pudlak Syndrome Platelet Storage Pool Deficiency
Griscelli Syndrome	Chediak-Higashi-Like Syndrome Griscelli-Prunieras Syndrome Partial Albinism-Immunodeficiency Syndrome Griscelli Disease Gs Hypopigmentation Immunodeficiency Disease Partial Albinism With Immunodeficiency Immunodeficiency Syndrome With Hypopigmentation Hypopigmentation-Immunodeficiency Disease
Frontotemporal Dementia	Pallidopontonigral Degeneration Frontotemporal Lobar Degeneration Semantic Dementia FTD Frontotemporal Lobe Dementia Multiple System Tauopathy With Presenile Dementia Dementia, Frontotemporal Frontotemporal Dementia With Parkinsonism Mstd Frontotemporal Lobar Degeneration With Tau Inclusions Ftld With Tau Inclusions Dementia, Frontotemporal, With Parkinsonism Fldem Ftdp17 Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex Ddpac Wilhelmsen-Lynch Disease Wld Ppnd Dementia, Frontotemporal, With Or Without Parkinsonism Semantic Primary Progressive Aphasia Semantic Variant Ppa Wilhemsen-Lynch Disease Frontotemporal Dementia-Amyotrophic Lateral Sclerosis Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17 Ftd-Als Ftld Pick Complex Pick Disease Of The Brain Frontotemporal Dementia With Parkinsonism-17 Grn-Related Frontotemporal Dementia Frontotemporal Dementia With Motor Neuron Disease Dementia In Fronto-Temporal Lobar Degeneration Ftd - [Frontotemporal Dementia] Temple Dementia Frontal Lobe Dementia
Piebald Trait	Piebaldism PBT Partial Albinism Albinoidism, Oculocutaneous, Autosomal Dominant
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Carpenter Syndrome 1	Carpenter Syndrome Acrocephalopolysyndactyly Type Ii Acps Ii CRPT1 Acrocephalopolysyndactyly Type 2 Acrocephalosyndactyly, Type Ii Acrocephalopolysyndactyly 2 Acps2 Acps 2 Type Ii Acrocephalosyndactyly Carpenter Syndrome, Type 1 Apert-Crouzon Disease
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 1	FTDALS1 Frontotemporal Dementia And/Or Motor Neuron Disease Ftdmnd Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia Alsftd Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis-1 Frontotemporal Dementia With Motor Neuron Disease Ftdals Ftd-Als Ftd-Mnd Frontotemporal Dementia With Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis With Frontotemporal Dementia 1 Amyotrophic Lateral Sclerosis/Frontotemporal Dementia Dementia, Frontotemporal, And/Or Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia 1 Frontotemporal Lobar Degeneration Grn-Related Frontotemporal Dementia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11552	RAB38 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	RAB38	VGNC	VGNC:81536
Felis catus	RAB38	VGNC	VGNC:81950
Rattus norvegicus	RAB38	RGD	RGD:628752
Mus musculus	RAB38	MGD	MGI:1919683
Bos taurus	RAB38	VGNC	VGNC:33646
Canis familiaris	RAB38	VGNC	VGNC:45280