RAB38 Antibody
(Synonyms: Ras-related protein Rab-38, Melanoma antigen NY-MEL-1, RAB38)RAB38 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to RAB38.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, ICC/IF
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
WB
WB: Western Blot
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:50-200 |
Product Details
RAB38 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to RAB38.
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Host Rabbit
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Clonality Polyclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 24 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 23 kDa
Synthetic peptide corresponding to the center region of human RAB38.
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
RAB38 is a The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB38 may be involved in melanosomal transport and docking. Involved in the proper sorting of TYRP1. Involved in peripheral melanosomal distribution of TYRP1 in melanocytes; the function, which probably is implicating vesicle-trafficking, includes cooperation with ANKRD27 and VAMP7 (By similarity). Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays an important role in the control of melanin production and melanosome biogenesis. In concert with RAB32, regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (By similarity)[1][2].
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Subcellular Localization
Cell membrane; Melanosome; Cytoplasmic vesicle, phagosome; Cytoplasmic vesicle, phagosome membrane; Melanosome membrane
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Expression
Tissue_Specificity: Expressed in melanocytes. -
Isoforms & Post-Translational Modification
RAB38 has an amino acid length of 211, molecular weight is 23712 Da.尽管至少有一种体外系统可以对异戊二烯化的 C 端进行加工和甲基化，但在正常表达 Rab-38 的体外系统以及体内环境中，异戊二烯化的 C 端不会被蛋白水解加工，也不会被甲基化RAB38 的氨基酸个数为 211 个，分子量为 23712 Da。Although at least one in vitro system can process and methylate the prenylated C-terminal, in an in vitro system that normally express Rab-38 and in vivo the prenylated C-terminal is not proteolytically processed and not methylated
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Subunit
Interacts with ANKRD27
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SwissProt ID
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Synonyms
Ras-related protein Rab-38, Melanoma antigen NY-MEL-1, RAB38
Documentation
[1]. Seto S, et al. Rab GTPases regulating phagosome maturation are differentially recruited to mycobacterial phagosomes. Traffic. 2011 Apr;12(4):407-20. [Content Brief]
[2]. Gerondopoulos A, et al. BLOC-3 mutated in Hermansky-Pudlak syndrome is a Rab32/38 guanine nucleotide exchange factor. Curr Biol. 2012 Nov 20;22(22):2135-9. [Content Brief]
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