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NFATC2 - nuclear factor of activated T cells 2 Gene

Also Known as NFAT1; NFATP

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4773

About NFATC2

Cytogenetic location: 20q13.2 Genomic coordinates (GRCh38): 20:51,386,963-51,562,839 (from NCBI)

This gene has 7 transcripts (splice variants), 274 orthologues, 4 paralogues and is associated with 83 phenotypes. Broad expression in gall bladder (RPKM 9.1), lymph node (RPKM 6.9) and 25 other tissues.

Summary

This gene is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Apr 2012]

NFATC2 Products (8)

mRNA	Protein	Name
NM_001136021.3	NP_001129493.1	nuclear factor of activated T-cells, cytoplasmic 2 isoform D
NM_001258292.2	NP_001245221.1	nuclear factor of activated T-cells, cytoplasmic 2 isoform E
NM_001258294.2	NP_001245223.1	nuclear factor of activated T-cells, cytoplasmic 2 isoform F
NM_001258295.2	NP_001245224.1	nuclear factor of activated T-cells, cytoplasmic 2 isoform G
NM_001258296.2	NP_001245225.1	nuclear factor of activated T-cells, cytoplasmic 2 isoform F
NM_001258297.2	NP_001245226.1	nuclear factor of activated T-cells, cytoplasmic 2 isoform G
NM_012340.5	NP_036472.2	nuclear factor of activated T-cells, cytoplasmic 2 isoform B
NM_173091.4	NP_775114.1	nuclear factor of activated T-cells, cytoplasmic 2 isoform C

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables 14-3-3 protein binding	EXP EXP: Inferred from Experiment	29432148	GOA
enables molecular adaptor activity	EXP EXP: Inferred from Experiment	29432148	GOA
enables phosphatase binding	IPI IPI: Inferred from physical interaction	26248042	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16873067	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in B cell receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	17875758	GOA
involved in DNA damage response	IMP IMP: Inferred from mutant phenotype	17875758	GOA
involved in cartilage development	IMP IMP: Inferred from mutant phenotype	35789258	GOA
involved in cell migration	IDA IDA: Inferred from direct assay	21871017	GOA
involved in negative regulation of vascular associated smooth muscle cell differentiation	IDA IDA: Inferred from direct assay	23853098	GOA
involved in positive regulation of B cell proliferation	IMP IMP: Inferred from mutant phenotype	17875758	GOA
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15790681	GOA
involved in response to xenobiotic stimulus	IMP IMP: Inferred from mutant phenotype	17875758	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	12656674	GOA
located in nucleus	IDA IDA: Inferred from direct assay	12370307	GOA
part of transcription factor AP-1 complex	IPI IPI: Inferred from physical interaction	9510247	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NFATC2 Protein Structure

RHD_DNA_bind

TIG

0
200
400
600
800
925 a.a.

Protein Preferred Names	Protein Names
nuclear factor of activated T-cells, cytoplasmic 2	NF-ATc2

NFATC2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	NFATC2	Q13469	VRK2	Homo sapiens	Q86Y07-1	Anti Tag CoIP	23105117
Intra	NFATC2	Q13469	LRRK2	Homo sapiens	Q5S007	Anti Tag CoIP	21983832
Intra	NFATC2	Q13469	CREB1	Homo sapiens	P16220	TAP	25609649
Intra	NFATC2	Q13469	USP22	Homo sapiens	Q9UPT9	Anti Tag CoIP	24561192

Cross: Cross-species interaction Intra: Intraspecies interaction

NFATC2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80242	NFAT1 Antibody (YA271)	WB, ICC/IF, IHC-P, FC	Human

Related Diseases

Diseases	Alias
Cardiomyopathy, Dilated, 1a	Dilated Cardiomyopathy 1a Cdcd1 CMD1A Cardiomyopathy, Familial Idiopathic Familial Dilated Cardiomyopathy With Conduction Defect Due To Lmna Mutation Cardiomyopathy, Dilated, With Conduction Defect 1 Cardiomyopathy, Idiopathic Dilated Cardiomyopathy, Congestive Dilated Cardiomyopathy With Conduction Defect 1 Cardiomyopathy Dilated With Conduction Defect Type 1 Cardiomyopathy, Dilated 1a Cardiomyopathy Dilated With Conduction Defect 1 Cardiomyopathy, Dilated, Type 1a
Cardiomyopathy, Dilated, 1h	Dilated Cardiomyopathy 1h Dilated Cardiomyopathy With Conduction Defect CMD1H Cardiomyopathy, Dilated, With Conduction Defect
Bone Epithelioid Hemangioma	Bone Hemangioma Hemangioma Of Bone Osseous Epithelioid Hemangioma Osseous Hemangioma
Dilated Cardiomyopathy	Familial Dilated Cardiomyopathy Primary Dilated Cardiomyopathy Idiopathic Dilated Cardiomyopathy Congestive Cardiomyopathy Idiopathic Dilation Cardiomyopathy Primary Familial Dilated Cardiomyopathy Cardiomyopathy, Dilated DCM Cardiomyopathy, Familial Dilated Dilated Cardiomyopathy, Familial Hypokinetic Dilated Cardiomyopathy, Familial Familial Idiopathic Cardiomyopathy Fdc Cardiomyopathy, Familial Idiopathic Idiopathic Cardiomegaly Dilated Congestive Cardiomyopathy Chronic Dilated Cardiomyopathy Ccm - [Congestive Cardiomyopathy] Cocm - [Congestive Cardiomyopathy] Dcm - [Dilated Cardiomyopathy] Dilated-Hypokinetic Cardiomyopathy Congestive Idiopathic Cardiomyopathy Primary Idiopathic Dilated Cardiomyopathy
Leukostasis
Small Cell Osteogenic Sarcoma	Small Cell Osteosarcoma Round Cell Osteosarcoma Osteosarcoma Small Cell
Chondrosarcoma, Extraskeletal Myxoid	Extraskeletal Myxoid Chondrosarcoma Emc Myxoid Extraosseous Chondrosarcoma
Extraosseous Chondrosarcoma	Extraskeletal Myxoid Chondrosarcoma
Conventional Osteosarcoma	Intracortical Osteosarcoma Conventional Central Osteosarcoma Intracortical Osteogenic Sarcoma Medullary Osteosarcoma
Narcolepsy	Paroxysmal Sleep Gelineau Syndrome Narcoleptic Syndrome Narcolepsy-Cataplexy Syndrome Cataplexy And Narcolepsy Narcolepsy, Without Cataplexy Gelineau'S Syndrome Narcolepsy With Or Without Cataplexy Narcolepsy Nos
Desmoplastic Small Round Cell Tumor	Dsrct Desmoplastic Small Round-Cell Tumor Desmoplastic Small Round-Cell Neoplasm
Bone Osteosarcoma	Osteosarcoma Of Bone Primary Osteosarcoma Of Bone
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09239	NFATC2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-162280	PROTAC BTK Degrader-9		/	Unkown
HY-RS09240	NFATC2IP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19067	Nfatc2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25557	Nfatc2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	NFATC2	MGD	MGI:102463
Canis familiaris	NFATC2	VGNC	VGNC:43767
Rattus norvegicus	NFATC2	RGD	RGD:1307690
Bos taurus	NFATC2	VGNC	VGNC:32031
Felis catus	NFATC2	VGNC	VGNC:68470
Macaca mulatta	NFATC2	VGNC	VGNC:75327
Others	NFATC2	NCBI