Multi-kinase-IN-14
Multi-kinase-IN-14 is an orally active and blood-brain barrier-permeable multi-kinase inhibitor. Multi-kinase-IN-14 reduces the excessive phosphorylation of α-synuclein by inhibiting four kinases (ABL1, DYRK1A, GSK3β, and LRRK2) and stabilizing microtubules. Multi-kinase-IN-14 is applicable for research on neurodegenerative diseases such as Parkinson’s disease and Alzheimer’s disease.
For research use only. We do not sell to patients.
- CAS No.: 2201083-51-2
- Formula: C17H14ClN5
- Molecular Weight:323.78
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
All α-synuclein Isoforms
More
Biological Activity
|
GSK-3β |
Abl1 |
DYRK1A |
Multi-kinase-IN-14 (10 μM) exhibits mild inhibition of ABL1, DYRK1A, GSK3β, and LRRK2 kinase activities in an in vitro kinase assay, with average inhibition rates of 56.5%, 48%, 61%, and 59%, respectively[1].
Multi-kinase-IN-14 (100 μM) inhibits the binding of colchicine (HY-16569) to tubulin with a 34% inhibition rate[1].
Multi-kinase-IN-14 (50 μM) inhibits the binding of vinblastine (HY-13780) to tubulin with a 15% inhibition rate[1].
Multi-kinase-IN-14 (4-8 μM; 10 days) reduces α-synuclein fibril-induced excessive phosphorylation at Ser129, nuclear fragmentation and condensation, and moderately increases acetylated α-tubulin levels in primary rat hippocampal cell cultures[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:Primary rat hippocampal cultures treated preformed fibrils
-
Concentration:8 μM
-
Incubation Time:10 days
-
Result:Reduced fragmented and condensed Hoechst+ nuclei in the fibril-treated group.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 2201083-51-2
-
Molecular Weight 323.78
-
Formula C17H14ClN5
-
SMILES
NC1=NC2=C(C(N(C3=CC=CC=C3)C)=N1)C4=C(C=CC=C4Cl)N2
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Multi-kinase-IN-14 Related Classifications
HY-181046 Related Classifications
Powered by Bioz