1. Cell Cycle/DNA Damage
    Cytoskeleton
    Autophagy
  2. Microtubule/Tubulin
    Autophagy

Vinblastine sulfate (Synonyms: Vincaleukoblastine sulfate salt)

Cat. No.: HY-13780 Purity: 99.87%
Handling Instructions

Vinblastine sulfate is a cytotoxic alkaloid used against various cancer types. Vinblastine sulfate inhibits the formation of microtubule and suppresses nAChR with an IC50 of 8.9 μM.

For research use only. We do not sell to patients.
Vinblastine sulfate Chemical Structure

Vinblastine sulfate Chemical Structure

CAS No. : 143-67-9

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10 mM * 1 mL in DMSO $77 In-stock
5 mg $50 In-stock
10 mg $77 In-stock
50 mg $264 In-stock
100 mg $365 In-stock
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Other Forms of Vinblastine sulfate:

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Description

Vinblastine sulfate is a cytotoxic alkaloid used against various cancer types. Vinblastine sulfate inhibits the formation of microtubule and suppresses nAChR with an IC50 of 8.9 μM.

IC50 & Target

IC50: 8.9 μM(nAChR)[1]

In Vitro

Vinblastine does not depolymerize spindle microtubules, yet it powerfully blocks mitosis (for example, IC50 0.8 nM in HeLa cells) and cells die by apoptosis[2]. In NB4 cells, vinblastine produces alteration of p53 and DNA fragmentation. Vinblastine treatment has an antiproliferative effect via the induction of apoptosis producing Bax/Bcl-2 imbalance. Vinblastine treatment suppresses NFκB expression and depresses NFκB-DNA binding activity while maintaining JNK activation that subsequently results in apoptotic response through caspase-dependent pathway[3]. Vinblastine is found to trigger apoptosis as evidenced by the loss of mitochondrial membrane potential, the release of both cytochrome c and apoptosis inducing factor, activation of caspase-9 and 3, and cleavage of Poly (ADP-ribose)-Polymerase[4].

In Vivo

Vinblastine is a widely used anticancer drug with undesired side effects. Its conjugation with carrier molecules could be an efficient strategy to reduce these side effects[5].

Clinical Trial
Sponsor Condition Start Date Phase
Childrens Hospital of Philadelphia Neurofibromatosis type I 2001-02-28 Phase 2
St Jude Children's Research Hospital Acute lymphoblastic leukemia 2012-10-31 Phase 2
St Jude Children's Research Hospital Hodgkins disease 2009-02-28 Phase 2
Eastern Cooperative Oncology Group Hodgkins disease 2012-04-30 Phase 2
Cancer and Leukemia Group B Hodgkins disease 2010-09-30 Phase 2
References
M.Wt

909.05

Formula

C₄₆H₆₀N₄O₁₃S

CAS No.

143-67-9

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 44 mg/mL

Purity: 99.87%

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Product Name:
Vinblastine sulfate
Cat. No.:
HY-13780
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