1. Cell Cycle/DNA Damage
    Cytoskeleton
    Autophagy
  2. Microtubule/Tubulin
    Autophagy
  3. Vinblastine sulfate

Vinblastine sulfate (Synonyms: Vincaleukoblastine sulfate salt)

Cat. No.: HY-13780 Purity: 99.85%
Handling Instructions

Vinblastine sulfate is a cytotoxic alkaloid used against various cancer types. Vinblastine sulfate inhibits the formation of microtubule and suppresses nAChR with an IC50 of 8.9 μM.

For research use only. We do not sell to patients.

Vinblastine sulfate Chemical Structure

Vinblastine sulfate Chemical Structure

CAS No. : 143-67-9

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 78 In-stock
Estimated Time of Arrival: December 31
5 mg USD 60 In-stock
Estimated Time of Arrival: December 31
10 mg USD 78 In-stock
Estimated Time of Arrival: December 31
50 mg USD 102 In-stock
Estimated Time of Arrival: December 31
100 mg USD 132 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 2 publication(s) in Google Scholar

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Description

Vinblastine sulfate is a cytotoxic alkaloid used against various cancer types. Vinblastine sulfate inhibits the formation of microtubule and suppresses nAChR with an IC50 of 8.9 μM.

IC50 & Target

IC50: 8.9 μM(nAChR)[1]

In Vitro

Vinblastine does not depolymerize spindle microtubules, yet it powerfully blocks mitosis (for example, IC50 0.8 nM in HeLa cells) and cells die by apoptosis[2]. In NB4 cells, vinblastine produces alteration of p53 and DNA fragmentation. Vinblastine treatment has an antiproliferative effect via the induction of apoptosis producing Bax/Bcl-2 imbalance. Vinblastine treatment suppresses NFκB expression and depresses NFκB-DNA binding activity while maintaining JNK activation that subsequently results in apoptotic response through caspase-dependent pathway[3]. Vinblastine is found to trigger apoptosis as evidenced by the loss of mitochondrial membrane potential, the release of both cytochrome c and apoptosis inducing factor, activation of caspase-9 and 3, and cleavage of Poly (ADP-ribose)-Polymerase[4].

In Vivo

Vinblastine is a widely used anticancer drug with undesired side effects. Its conjugation with carrier molecules could be an efficient strategy to reduce these side effects[5].

Clinical Trial
Molecular Weight

909.05

Formula

C₄₆H₆₀N₄O₁₃S

CAS No.

143-67-9

SMILES

[H][[email protected]@]12C[[email protected]@](C3=C(OC)C=C(N([[email protected]]4([H])[[email protected]@]56[[email protected]]7([H])[[email protected]](C=CCN7CC6)(CC)[[email protected]@H](OC(C)=O)[[email protected]@]4(C(OC)=O)O)C)C5=C3)(C(OC)=O)C(NC8=C9C=CC=C8)=C9CC[[email protected]](C2)C[[email protected]](O)(CC)C1.OS(=O)(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 44 mg/mL (48.40 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1000 mL 5.5002 mL 11.0005 mL
5 mM 0.2200 mL 1.1000 mL 2.2001 mL
10 mM 0.1100 mL 0.5500 mL 1.1000 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (2.75 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (2.75 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (2.75 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.85%

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Keywords:

VinblastineVincaleukoblastineMicrotubule/TubulinAutophagyInhibitorinhibitorinhibit

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Product name:
Vinblastine sulfate
Cat. No.:
HY-13780
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