Successful, we will reply to you quickly.

OK

Please select the quantity.

OK

Your message is being sent, please wait.

Close

test

Close

Send mail failed, please send again!

Close

Products are for research use only. Not for human use. We do not sell to patients.

Signaling Pathway

Vinorelbine ditartrate

HY-12053A

(KW-2307; Nor-5'-anhydrovinblastine ditartrate)

Vinorelbine ditartrate

Vinorelbine ditartrate Chemical Structure

Vinorelbine(KW-2307 base) is an anti-mitotic agent which inhibits the proliferation of Hela cells with IC50 of 1.25 nM.

Size Price Stock Quantity
10 mM * 1 mL in DMSO $71 In-stock
10 mg $60 In-stock
50 mg $180 In-stock
100 mg Get quote
200 mg Get quote
Size Price Stock Quantity
10 mM * 1 mL in DMSO €70 In-stock
10 mg €59 In-stock
50 mg €176 In-stock
100 mg Get quote
200 mg Get quote

* Please select Quantity before adding items.

Bulk Inquiry

Inquiry Information
Product name: Vinorelbine ditartrate
Cat. No.: HY-12053A

Vinorelbine ditartrate Data Sheet

  • View current batch:

    Purity: 99.83%

  • Network Version

    DataSheet

    Pdf Version Network Version

    MSDS

    Pdf Version

    COA

    Pdf Version

    NMR

    Pdf Version

    LCMS

Related Compound Libraries

Biological Activity of Vinorelbine ditartrate

Vinorelbine(KW-2307 base) is an anti-mitotic agent which inhibits the proliferation of Hela cells with IC50 of 1.25 nM.
IC50 value:
Target: Anti-mitotic
Vinorelbine (Navelbine) is the first 5′NOR semi-synthetic vinca alkaloid and exerts its activity through the MAPK (p38) pathway with median IC90 and IC50 of 15.5 and 2.3 μM. Vinorelbine induces concentration- and time-dependent increases in the protein levels of both p53 and p21 in hormone-dependent (AD) LNCaP cells, and can restore p21 expression in androgen-independent (AI) prostate cancer cells through both p53-dependent and-independent pathways.

Chemical Information

M.Wt 1079.11 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C₅₃H₆₆N₄O₂₀
CAS No 125317-39-7
Solvent & Solubility

DMSO: ≥ 46 mg/mL

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 0.9267 mL 4.6334 mL 9.2669 mL
5 mM 0.1853 mL 0.9267 mL 1.8534 mL
10 mM 0.0927 mL 0.4633 mL 0.9267 mL

Clinical Information of Vinorelbine ditartrate

Product Name Sponsor Only Condition Start Date End Date Phase Last Change Date
Vinorelbine ditartrate Sun Yat-Sen University Esophagus tumor 30-JUN-07 31-AUG-14 Phase 3 10-SEP-13
Heinrich Heine Universitat Dusseldorf Metastatic breast cancer 29-FEB-12 31-MAR-18 Phase 3 20-JUN-12
National Hospital Organization Kinki-chuo Chest Medical Center Metastatic non small cell lung cancer 30-APR-04 Phase 3 11-NOV-13
Merck & Co Inc Ovary tumor 30-APR-11 31-MAY-15 Phase 3 21-NOV-13
Eisai Inc Metastatic non small cell lung cancer 30-SEP-11 Phase 3 14-NOV-13

References on Vinorelbine ditartrate

Other Forms

Inhibitor Kit
  • 10-Deacetyl-7-xylosyl paclitaxel

    10-Deacetyl-7-xylosyl paclitaxel is a Paclitaxel derivative with improved pharmacological features and higher water solubility.

  • 10-Oxo Docetaxel

    10-Oxo Docetaxel(Docetaxel Impurity) is a novel taxoid having remarkable anti-tumor properties and a Docetaxel intermediate.

  • 2-Methoxyestradiol

    2-methoxyestradiol (2ME2; NSC-659853) is a natural metabolite of estrogen that is known to inhibit HIF-1 alpha with an IC50 of 0.71 (plusmn) 0.11 (mu)M for the inhibition of BPAEC migration.

  • 4'-Demethylepipodophyllotoxin

    4(acute)-Demethylepipodophyllotoxin(4(acute)-DMEP) is a key intermediate compound for the preparation of podophyllotoxin-type anti-cancer drugs; a potent inhibitor of microtubule assembly.

  • 7-Epi-10-oxo-docetaxel

    7-Epi-10-oxo-docetaxel (Docetaxel Impurity D) is a impurity of docetaxel detected by high performance liquid chromatography (HPLC).

  • 7-Epi-docetaxel

    7-Epi-10-oxo-docetaxel (Docetaxel Impurity C; 7-Epitaxotere) is a impurity of docetaxel.

  • 7-xylosyltaxol

    7-xylosyltaxol(Taxol-7-xyloside) is a taxol (Paclitaxel) derivative; Paclitaxel binds to tubulin and inhibits the disassembly of microtubules.

  • ABT-751

    ABT-751(E 7010) is a novel bioavailable tubulin-binding and antimitotic sulfonamide agent with IC50 of about 1.5 and 3.4 (mu)M in neuroblastoma and non-neuroblastoma cell lines, respectively.

  • Auristatin E

    Auristatin E is a cytotoxic tubulin modifier with potent and selective antitumor activity; MMAE analog and cytotoxin in Antibody-drug conjugates.

  • Auristatin F

    Auristatin F is a cytotoxic tubulin modifier with potent and selective antitumor activity; MMAF analog and cytotoxin in Antibody-drug conjugates.

MORE