1. Cell Cycle/DNA Damage
    Cytoskeleton
    Autophagy
  2. Microtubule/Tubulin
    Autophagy

Vinorelbine ditartrate (Synonyms: KW-2307; Nor-5'-anhydrovinblastine ditartrate)

Cat. No.: HY-12053A Purity: 99.62%
Handling Instructions

Vinorelbine (ditartrate) is an anti-mitotic agent which inhibits the proliferation of Hela cells with IC50 of 1.25 nM.

For research use only. We do not sell to patients.

Vinorelbine ditartrate Chemical Structure

Vinorelbine ditartrate Chemical Structure

CAS No. : 125317-39-7

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 85 In-stock
Estimated Time of Arrival: December 31
10 mg USD 72 In-stock
Estimated Time of Arrival: December 31
50 mg USD 216 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Other Forms of Vinorelbine ditartrate:

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Vinorelbine (ditartrate) is an anti-mitotic agent which inhibits the proliferation of Hela cells with IC50 of 1.25 nM.

In Vitro

Vinorelbine (0.5-5 nM) inhibits cell proliferation by 50% (IC50) at concentrations of 1.25 nM. At concentration of 8 nM vinorelbine, no cells are in anaphase[1]. Vinorelbine time-dependently induces the p53 and p21WAFI/CIP1 expression in androgen-dependent (AD) and- independent (AI) prostate cancer cell lines. Vinorelbine stimulates reporter genes in a concentration-dependent manner[2].

In Vivo

After vinorelbine treatment, the first neutropenicepisode occurred after the first (4 dogs), second (1), or sixth(1) vinorelbine treatment in the dogs[3]. Vinorelbine is tolerated at a weekly interval in tumor-bearing cats, with an MTD of 11.5 mg/m2[4].

Clinical Trial
Solvent & Solubility
In Vitro: 

DMSO : ≥ 46 mg/mL (42.63 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9267 mL 4.6334 mL 9.2669 mL
5 mM 0.1853 mL 0.9267 mL 1.8534 mL
10 mM 0.0927 mL 0.4633 mL 0.9267 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

1079.11

Formula

C₅₃H₆₆N₄O₂₀

CAS No.

125317-39-7

SMILES

CC[[email protected]@]1(C=CCN2CC3)[[email protected]@]2([H])[[email protected]@]3(C(C=C([[email protected]@](C4=C5C(C=CC=C6)=C6N4)(CC(C=C(CC)C7)([H])CN7C5)C(OC)=O)C(OC)=C8)=C8N9C)[[email protected]]9([H])[[email protected]](C(OC)=O)(O)[[email protected]@H]1OC(C)=O.O=C(O)[[email protected]](O)[[email protected]@H](O)C(O)=O.O=C(O)[[email protected]](O)[[email protected]@H](O)C(O)=O

Storage

4°C, protect from light

Shipping

Room temperature in continental US; may vary elsewhere

Purity: 99.62%

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Product Name:
Vinorelbine ditartrate
Cat. No.:
HY-12053A
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Vinorelbine ditartrate

Cat. No.: HY-12053A