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(KW-2307; Nor-5'-anhydrovinblastine ditartrate)
Vinorelbine ditartrate Chemical Structure
|Product name: Vinorelbine ditartrate|
|Cat. No.: HY-12053A|
Vinorelbine(KW-2307 base) is an anti-mitotic agent which inhibits the proliferation of Hela cells with IC50 of 1.25 nM.
Vinorelbine (Navelbine) is the first 5′NOR semi-synthetic vinca alkaloid and exerts its activity through the MAPK (p38) pathway with median IC90 and IC50 of 15.5 and 2.3 μM. Vinorelbine induces concentration- and time-dependent increases in the protein levels of both p53 and p21 in hormone-dependent (AD) LNCaP cells, and can restore p21 expression in androgen-independent (AI) prostate cancer cells through both p53-dependent and-independent pathways.
|M.Wt||1079.11||Storage||Please store the product under the recommended conditions in the Certificate of Analysis.|
|Solvent & Solubility||
DMSO: ≥ 46 mg/mL
|1 mg||5 mg||10 mg|
|1 mM||0.9267 mL||4.6334 mL||9.2669 mL|
|5 mM||0.1853 mL||0.9267 mL||1.8534 mL|
|10 mM||0.0927 mL||0.4633 mL||0.9267 mL|
|Product Name||Sponsor Only||Condition||Start Date||End Date||Phase||Last Change Date|
|Vinorelbine ditartrate||Sun Yat-Sen University||Esophagus tumor||30-JUN-07||31-AUG-14||Phase 3||10-SEP-13|
|Heinrich Heine Universitat Dusseldorf||Metastatic breast cancer||29-FEB-12||31-MAR-18||Phase 3||20-JUN-12|
|National Hospital Organization Kinki-chuo Chest Medical Center||Metastatic non small cell lung cancer||30-APR-04||Phase 3||11-NOV-13|
|Merck & Co Inc||Ovary tumor||30-APR-11||31-MAY-15||Phase 3||21-NOV-13|
|Eisai Inc||Metastatic non small cell lung cancer||30-SEP-11||Phase 3||14-NOV-13|
. Ngan VK, et al. Mechanism of mitotic block and inhibition of cell proliferation by the semisynthetic Vinca alkaloids vinorelbine and its newer derivative vinflunine. Mol Pharmacol. 2001 Jul;60(1):225-32.
CAS No.: 71486-22-1 Get quote
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