1. Cell Cycle/DNA Damage
  2. Microtubule/Tubulin

Vinorelbine ditartrate (Synonyms: KW-2307; Nor-5'-anhydrovinblastine ditartrate)

Cat. No.: HY-12053A Purity: 99.62%
Handling Instructions

Vinorelbine (ditartrate) is an anti-mitotic agent which inhibits the proliferation of Hela cells with IC50 of 1.25 nM.

For research use only. We do not sell to patients.
Vinorelbine ditartrate Chemical Structure

Vinorelbine ditartrate Chemical Structure

CAS No. : 125317-39-7

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 85 In-stock
10 mg USD 72 In-stock
50 mg USD 216 In-stock
100 mg   Get quote  
200 mg   Get quote  

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Other Forms of Vinorelbine ditartrate:

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References


Vinorelbine (ditartrate) is an anti-mitotic agent which inhibits the proliferation of Hela cells with IC50 of 1.25 nM.

In Vitro

Vinorelbine (0.5-5 nM) inhibits cell proliferation by 50% (IC50) at concentrations of 1.25 nM. At concentration of 8 nM vinorelbine, no cells are in anaphase[1]. Vinorelbine time-dependently induces the p53 and p21WAFI/CIP1 expression in androgen-dependent (AD) and- independent (AI) prostate cancer cell lines. Vinorelbine stimulates reporter genes in a concentration-dependent manner[2].

In Vivo

After vinorelbine treatment, the first neutropenicepisode occurred after the first (4 dogs), second (1), or sixth(1) vinorelbine treatment in the dogs[3]. Vinorelbine is tolerated at a weekly interval in tumor-bearing cats, with an MTD of 11.5 mg/m2[4].

Clinical Trial
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 0.9267 mL 4.6334 mL 9.2669 mL
5 mM 0.1853 mL 0.9267 mL 1.8534 mL
10 mM 0.0927 mL 0.4633 mL 0.9267 mL
Please refer to the solubility information to select the appropriate solvent.
Animal Administration

Vinorelbine is diluted in 0.9% NaCl to a concentration of 1.5 mg/mL.

As defined by the study, VRL1 is diluted in 0.9% NaCl to a concentration of 1.5 mg/mL, and given IV over 5 minutes. The intended treatment interval is 7 days for up to 4 treatments. After receiving 4 weekly doses, cats are eligible to continue VRL treatment every 2 weeks. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight







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4°C, protect from light


Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 46 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

Purity: 99.62%

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