1. Cell Cycle/DNA Damage
    Cytoskeleton
  2. Microtubule/Tubulin

Vinorelbine (Synonyms: KW-2307 base)

Cat. No.: HY-12053
Handling Instructions

Vinorelbine(KW-2307 base) is an anti-mitotic agent which inhibits the proliferation of Hela cells with IC50 of 1.25 nM.

For research use only. We do not sell to patients.
Vinorelbine Chemical Structure

Vinorelbine Chemical Structure

CAS No. : 71486-22-1

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10 mg $60 Backordered
50 mg $180 Backordered

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Other Forms of Vinorelbine:

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Description

Vinorelbine(KW-2307 base) is an anti-mitotic agent which inhibits the proliferation of Hela cells with IC50 of 1.25 nM. IC50 value: Target: Anti-mitotic Vinorelbine (Navelbine) is the first 5′NOR semi-synthetic vinca alkaloid and exerts its activity through the MAPK (p38) pathway with median IC90 and IC50 of 15.5 and 2.3 μM. Vinorelbine induces concentration- and time-dependent increases in the protein levels of both p53 and p21 in hormone-dependent (AD) LNCaP cells, and can restore p21 expression in androgen-independent (AI) prostate cancer cells through both p53-dependent and-independent pathways.

Clinical Trial
Sponsor Condition Start Date Phase
Eisai Inc Metastatic non small cell lung cancer 2011-09-30 Phase 3
Chinese Academy of Medical Sciences Breast tumor 2010-07-31 Phase 3
Shanghai Jiao Tong University Non-small-cell lung cancer 2007-07-31 Phase 3
Boehringer Ingelheim Corp Metastatic breast cancer 2010-06-30 Phase 3
MolMed SpA Mesothelioma 2010-03-31 Phase 3
References
M.Wt

778.93

Formula

C₄₅H₅₄N₄O₈

CAS No.

71486-22-1

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

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Vinorelbine
Cat. No.:
HY-12053
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