1. Cell Cycle/DNA Damage
  2. Microtubule/Tubulin

Vinorelbine (Synonyms: KW-2307 base)

Cat. No.: HY-12053
Handling Instructions

Vinorelbine is an anti-mitotic agent which inhibits the proliferation of Hela cells with IC50 of 1.25 nM.

For research use only. We do not sell to patients.
Vinorelbine Chemical Structure

Vinorelbine Chemical Structure

CAS No. : 71486-22-1

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10 mg USD 72 Get quote
50 mg USD 216 Get quote

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Other In-stock Forms of Vinorelbine:

Other Forms of Vinorelbine:

  • Biological Activity

  • Protocol

  • Technical Information

  • References


Vinorelbine is an anti-mitotic agent which inhibits the proliferation of Hela cells with IC50 of 1.25 nM.

In Vitro

Vinorelbine (0.5-5 nM) inhibits cell proliferation by 50% (IC50) at concentrations of 1.25 nM. At concentration of 8 nM vinorelbine, no cells are in anaphase[1]. Vinorelbine time-dependently induces the p53 and p21WAFI/CIP1 expression in androgen-dependent (AD) and- independent (AI) prostate cancer cell lines. Vinorelbine stimulates reporter genes in a concentration-dependent manner[2].

In Vivo

After vinorelbine treatment, the first neutropenicepisode occurred after the first (4 dogs), second (1), or sixth(1) vinorelbine treatment in the dogs[3]. Vinorelbine is tolerated at a weekly interval in tumor-bearing cats, with an MTD of 11.5 mg/m2[4].

Clinical Trial
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 1.2838 mL 6.4191 mL 12.8381 mL
5 mM 0.2568 mL 1.2838 mL 2.5676 mL
10 mM 0.1284 mL 0.6419 mL 1.2838 mL
Please refer to the solubility information to select the appropriate solvent.
Animal Administration

Vinorelbine is diluted in 0.9% NaCl to a concentration of 1.5 mg/mL.

As defined by the study, VRL1 is diluted in 0.9% NaCl to a concentration of 1.5 mg/mL, and given IV over 5 minutes. The intended treatment interval is 7 days for up to 4 treatments. After receiving 4 weekly doses, cats are eligible to continue VRL treatment every 2 weeks at the owner's expense. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight







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Please store the product under the recommended conditions in the Certificate of Analysis.


Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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