2201083-51-2
2201083-51-2
Chemical Structure
Multi-kinase-IN-14
- CAS. Nr.: 2201083-51-2
- Formula:C17H14ClN5
- Molecular Weight:323.78
InChIKey: JVSTZWCAMAMKEK-UHFFFAOYSA-N
SMILES: NC1=NC2=C(C(N(C3=CC=CC=C3)C)=N1)C4=C(C=CC=C4Cl)N2
Biological Activity: Multi-kinase-IN-14 is an orally active and blood-brain barrier-permeable multi-kinase inhibitor. Multi-kinase-IN-14 reduces the excessive phosphorylation of α-synuclein by inhibiting four kinases (ABL1, DYRK1A, GSK3β, and LRRK2) and stabilizing microtubules. Multi-kinase-IN-14 is applicable for research on neurodegenerative diseases such as Parkinson’s disease and Alzheimer’s disease[1].
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Multi-kinase-IN-14 | Multi-kinase-IN-14 is an orally active and blood-brain barrier-permeable multi-kinase inhibitor. Multi-kinase-IN-14 reduces the excessive phosphorylation of α-synuclein by inhibiting four kinases (ABL1, DYRK1A, GSK3β, and LRRK2) and stabilizing microtubules. Multi-kinase-IN-14 is applicable for research on neurodegenerative diseases such as Parkinson’s disease and Alzheimer’s disease. | |||||||||||||||||||||
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References
Keywords
