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BAG5 - BAG cochaperone 5 Gene

Also Known as BAG-5; CMD2F

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9529

About BAG5

Cytogenetic location: 14q32.33 Genomic coordinates (GRCh38): 14:103,556,551-103,562,657 (from NCBI)

This gene has 3 transcripts (splice variants), 204 orthologues, 2 paralogues and is associated with 1 phenotype. Broad expression in testis (RPKM 41.2), thyroid (RPKM 15.2) and 24 other tissues.

Summary

The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell Apoptosis and growth related proteins including Bcl-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/HSP70. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

BAG5 Products (3)

mRNA	Protein	Name
NM_001015048.3	NP_001015048.1	BAG family molecular chaperone regulator 5
NM_001015049.5	NP_001015049.2	BAG family molecular chaperone regulator 5
NM_004873.4	NP_004864.1	BAG family molecular chaperone regulator 5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	24510904	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	24475098	GOA
enables protein-folding chaperone binding	IPI IPI: Inferred from physical interaction	15603737	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	24270810	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in Golgi organization	IMP IMP: Inferred from mutant phenotype	24510904	GOA
involved in negative regulation of neuron projection development	IDA IDA: Inferred from direct assay	24510904	GOA
involved in negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	IDA IDA: Inferred from direct assay	24475098	GOA
involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	24475098	GOA
involved in negative regulation of protein ubiquitination	IDA IDA: Inferred from direct assay	25006867	GOA
involved in negative regulation of protein ubiquitination	IMP IMP: Inferred from mutant phenotype	24475098	GOA
involved in protein stabilization	IDA IDA: Inferred from direct assay	25006867	GOA
involved in regulation of inclusion body assembly	IMP IMP: Inferred from mutant phenotype	15603737	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytosol	IDA IDA: Inferred from direct assay	24510904	GOA
located in inclusion body	IDA IDA: Inferred from direct assay	15603737	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	24475098	GOA
located in nucleus	IDA IDA: Inferred from direct assay	24510904	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	15603737	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BAG5 Protein Structure

BAG

0
100
200
300
400
447 a.a.

Protein Preferred Names	Protein Names
BAG family molecular chaperone regulator 5	BCL2 associated athanogene 5

BAG5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	BAG5	Q9UL15	LRRK1	Homo sapiens	Q38SD2	Protein Array	24947832
Intra	BAG5	Q9UL15	DES	Homo sapiens	P17661	Y2H Array	32296183
Intra	BAG5	Q9UL15	DES	Homo sapiens	P17661	Y2H Prey Pooling	32296183
Intra	BAG5	Q9UL15	GOLGA6A	Homo sapiens	Q9NYA3	Y2H Array	32296183
Intra	BAG5	Q9UL15	GOLGA6A	Homo sapiens	Q9NYA3	Y2H Prey Pooling	32296183
Intra	BAG5	Q9UL15	LCE2C	Homo sapiens	Q5TA81	Y2H Prey Pooling	32296183
Intra	BAG5	Q9UL15	LCE2C	Homo sapiens	Q5TA81	Y2H Array	32296183
Intra	BAG5	Q9UL15	TOM1	Homo sapiens	O60784-2	Y2H Array	32296183
Intra	BAG5	Q9UL15	TOM1	Homo sapiens	O60784-2	Y2H Prey Pooling	32296183
Intra	BAG5	Q9UL15	LRRK2	Homo sapiens	Q5S007	Pull Down	24510904
Intra	BAG5	Q9UL15	LRRK2	Homo sapiens	Q5S007	Anti Tag CoIP	24510904
Intra	BAG5	Q9UL15	HSPA1A	Homo sapiens	P08107	Anti Tag CoIP	24510904
Intra	BAG5	Q9UL15	TRIM27	Homo sapiens	P14373	Y2H Prey Pooling	32296183
Intra	BAG5	Q9UL15	TRIM27	Homo sapiens	P14373	Validated Y2H	25416956
Intra	BAG5	Q9UL15	TRIM27	Homo sapiens	P14373	Y2H Array	25416956
Intra	BAG5	Q9UL15	TRIM27	Homo sapiens	P14373	Y2H Array	32296183
Intra	BAG5	Q9UL15	FAM118B	Homo sapiens	Q9BPY3	Y2H Array	25416956
Intra	BAG5	Q9UL15	THAP1	Homo sapiens	Q9NVV9	Y2H Prey Pooling	32296183
Intra	BAG5	Q9UL15	THAP1	Homo sapiens	Q9NVV9	Y2H Array	25416956
Intra	BAG5	Q9UL15	THAP1	Homo sapiens	Q9NVV9	Y2H Array	32296183
Intra	BAG5	Q9UL15	THAP1	Homo sapiens	Q9NVV9	Y2H Prey Pooling	25416956
Intra	BAG5	Q9UL15	MAD1L1	Homo sapiens	Q9Y6D9	Anti Tag CoIP	25036637
Intra	BAG5	Q9UL15	MAD1L1	Homo sapiens	Q9Y6D9	Validated Y2H	32296183
Intra	BAG5	Q9UL15	MAD1L1	Homo sapiens	Q9Y6D9	Anti Tag CoIP	33961781
Intra	BAG5	Q9UL15	MAD1L1	Homo sapiens	Q9Y6D9	Validated Y2H	25416956
Intra	BAG5	Q9UL15	MAD1L1	Homo sapiens	Q9Y6D9	Y2H Array	25416956
Intra	BAG5	Q9UL15	MAD1L1	Homo sapiens	Q9Y6D9	Y2H Prey Pooling	32296183
Intra	BAG5	Q9UL15	MAD1L1	Homo sapiens	Q9Y6D9	Y2H Array	32296183
Intra	BAG5	Q9UL15	BANP	Homo sapiens	Q8N9N5	Y2H Array	25416956
Intra	BAG5	Q9UL15	KASH5	Homo sapiens	Q8N6L0	Y2H Prey Pooling	32296183
Intra	BAG5	Q9UL15	KASH5	Homo sapiens	Q8N6L0	Y2H Array	25416956
Intra	BAG5	Q9UL15	KASH5	Homo sapiens	Q8N6L0	Y2H Array	32296183
Intra	BAG5	Q9UL15	q53fc7_human	Homo sapiens	Q53FC7	Lumier	25036637

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Cardiomyopathy, Dilated, 2f	CMD2F Dilated Cardiomyopathy 2f Cardiomyopathy, Dilated 2f
Familial Isolated Dilated Cardiomyopathy	Familial Or Idiopathic Dilated Cardiomyopathy
Spinocerebellar Ataxia, Autosomal Recessive 16	Autosomal Recessive Spinocerebellar Ataxia 16 SCAR16 Autosomal Recessive Cerebellar Ataxia Due To Stub1 Deficiency Spinocerebellar Ataxia Autosomal Recessive Type 16 Spinocerebellar Ataxia, Autosomal Recessive, 16 Ataxia, Spinocerebellar, Autosomal Recessive, Type 16

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01346	BAG5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22109	Bag5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28631	Bag5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	BAG5	VGNC	VGNC:26409
Canis familiaris	BAG5	VGNC	VGNC:38367
Rattus norvegicus	BAG5	RGD	RGD:1310847
Macaca mulatta	BAG5	VGNC	VGNC:70221
Felis catus	BAG5	VGNC	VGNC:81031
Mus musculus	BAG5	MGD	MGI:1917619
Others	BAG5	NCBI