THAP1 - THAP domain containing 1 Gene

Also Known as DYT6

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 55145

About THAP1

Cytogenetic location: 8p11.21 Genomic coordinates (GRCh38): 8:42,836,674-42,843,325 (from NCBI)

This gene has 4 transcripts (splice variants), 198 orthologues, 7 paralogues and is associated with 3 phenotypes. Ubiquitous expression in testis (RPKM 7.0), thyroid (RPKM 5.5) and 25 other tissues.

Summary

The protein encoded by this gene contains a THAP domain, a conserved DNA-binding domain. This protein colocalizes with the Apoptosis response protein PAWR/PAR-4 in promyelocytic leukemia (PML) nuclear bodies, and functions as a proapoptotic factor that links PAWR to PML nuclear bodies. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

THAP1 Products (2)

mRNA	Protein	Name
NM_018105.3	NP_060575.1	THAP domain-containing protein 1 isoform 1
NM_199003.2	NP_945354.1	THAP domain-containing protein 1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	20976771	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	17003378	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	28299530	GOA
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	15863623	GOA
enables sequence-specific DNA binding	IMP IMP: Inferred from mutant phenotype	19182804	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	15863623	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	17003378	GOA
involved in endothelial cell proliferation	IMP IMP: Inferred from mutant phenotype	17003378	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	20976771	GOA
involved in regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	17003378	GOA
involved in regulation of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	17003378	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	17003378	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

THAP1 Protein Structure

THAP

0
100
200
213 a.a.

Protein Preferred Names	Protein Names
THAP domain-containing protein 1	4833431A01Rik

THAP1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	THAP1	Q9NVV9	KRTAP10-7	Homo sapiens	P60409	Validated Y2H	25416956
Intra	THAP1	Q9NVV9	KRTAP10-7	Homo sapiens	P60409	Y2H Prey Pooling	25416956
Intra	THAP1	Q9NVV9	KRTAP10-7	Homo sapiens	P60409	Y2H Array	25416956
Intra	THAP1	Q9NVV9	PRR20C	Homo sapiens	P86479	Y2H Prey Pooling	25416956
Intra	THAP1	Q9NVV9	PRR20C	Homo sapiens	P86479	Validated Y2H	25416956
Intra	THAP1	Q9NVV9	PRR20C	Homo sapiens	P86479	Y2H Array	25416956
Intra	THAP1	Q9NVV9	NKAPD1	Homo sapiens	Q6ZUT1-2	Y2H Array	25416956
Intra	THAP1	Q9NVV9	NKAPD1	Homo sapiens	Q6ZUT1-2	Validated Y2H	25416956
Intra	THAP1	Q9NVV9	UBE2I	Homo sapiens	Q7KZS0	Y2H Prey Pooling	32296183
Intra	THAP1	Q9NVV9	UBE2I	Homo sapiens	Q7KZS0	Y2H Array	32296183
Intra	THAP1	Q9NVV9	BEND7	Homo sapiens	Q8N7W2-2	Y2H Prey Pooling	32296183
Intra	THAP1	Q9NVV9	BEND7	Homo sapiens	Q8N7W2-2	Y2H Array	32296183
Intra	THAP1	Q9NVV9	TPM3	Homo sapiens	Q5VU62	Y2H Prey Pooling	25416956
Intra	THAP1	Q9NVV9	TPM3	Homo sapiens	Q5VU62	Validated Y2H	25416956
Intra	THAP1	Q9NVV9	AKAP17A	Homo sapiens	Q02040-3	Y2H Prey Pooling	25416956
Intra	THAP1	Q9NVV9	AKAP17A	Homo sapiens	Q02040-3	Validated Y2H	25416956
Intra	THAP1	Q9NVV9	AKAP17A	Homo sapiens	Q02040-3	Y2H Array	25416956
Intra	THAP1	Q9NVV9	RIPPLY1	Homo sapiens	Q0D2K3	Validated Y2H	25416956
Intra	THAP1	Q9NVV9	ARL6IP4	Homo sapiens	Q66PJ3-3	Y2H Prey Pooling	25416956
Intra	THAP1	Q9NVV9	ARL6IP4	Homo sapiens	Q66PJ3-3	Y2H Array	25416956
Intra	THAP1	Q9NVV9	PID1	Homo sapiens	Q7Z2X4	Validated Y2H	25416956
Intra	THAP1	Q9NVV9	FAM133A	Homo sapiens	Q8N9E0	Validated Y2H	25416956
Intra	THAP1	Q9NVV9	FAM133A	Homo sapiens	Q8N9E0	Y2H Array	25416956
Intra	THAP1	Q9NVV9	GAPDHS	Homo sapiens	O14556	Anti Tag CoIP	33961781
Intra	THAP1	Q9NVV9	GAPDHS	Homo sapiens	O14556	Anti Tag CoIP	28514442
Intra	THAP1	Q9NVV9	ZNF526	Homo sapiens	Q8TF50	Y2H Prey Pooling	32296183
Intra	THAP1	Q9NVV9	ZNF526	Homo sapiens	Q8TF50	Y2H Array	32296183
Intra	THAP1	Q9NVV9	MIS18A	Homo sapiens	Q9NYP9	Validated Y2H	32296183
Intra	THAP1	Q9NVV9	MIS18A	Homo sapiens	Q9NYP9	Y2H Array	32296183
Intra	THAP1	Q9NVV9	MIS18A	Homo sapiens	Q9NYP9	Y2H Prey Pooling	32296183
Intra	THAP1	Q9NVV9	RALYL	Homo sapiens	Q86SE5-3	Y2H Array	32296183
Intra	THAP1	Q9NVV9	RALYL	Homo sapiens	Q86SE5-3	Y2H Prey Pooling	32296183
Intra	THAP1	Q9NVV9	RALYL	Homo sapiens	Q86SE5-3	Validated Y2H	25910212
Intra	THAP1	Q9NVV9	RALYL	Homo sapiens	Q86SE5-3	Y2H Bait-Prey Pool	25910212
Intra	THAP1	Q9NVV9	RALYL	Homo sapiens	Q86SE5-3	Y2H Array	25910212
Intra	THAP1	Q9NVV9	PRKAA1	Homo sapiens	Q13131	Validated Y2H	25416956
Intra	THAP1	Q9NVV9	PRKAA1	Homo sapiens	Q13131	Y2H Prey Pooling	25416956
Intra	THAP1	Q9NVV9	PRKAA1	Homo sapiens	Q13131	Y2H Array	25416956
Intra	THAP1	Q9NVV9	GPATCH2L	Homo sapiens	Q9NWQ4-1	Validated Y2H	32296183
Intra	THAP1	Q9NVV9	POU6F2	Homo sapiens	P78424	Y2H Prey Pooling	32296183
Intra	THAP1	Q9NVV9	POU6F2	Homo sapiens	P78424	Y2H Array	32296183
Intra	THAP1	Q9NVV9	CHD2	Homo sapiens	O14647	Y2H Array	25416956
Intra	THAP1	Q9NVV9	CHD2	Homo sapiens	O14647	Y2H Prey Pooling	25416956
Intra	THAP1	Q9NVV9	NDUFAB1	Homo sapiens	O14561	Y2H Prey Pooling	32296183
Intra	THAP1	Q9NVV9	NDUFAB1	Homo sapiens	O14561	Y2H Array	32296183
Intra	THAP1	Q9NVV9	RNF4	Homo sapiens	P78317	Y2H Array	32296183
Intra	THAP1	Q9NVV9	RNF4	Homo sapiens	P78317	Y2H Prey Pooling	32296183
Intra	THAP1	Q9NVV9	ZNF408	Homo sapiens	Q9H9D4	Y2H Prey Pooling	32296183
Intra	THAP1	Q9NVV9	ZNF408	Homo sapiens	Q9H9D4	Y2H Array	32296183
Intra	THAP1	Q9NVV9	ZNF408	Homo sapiens	Q9H9D4	Y2H Pooling	16189514
Intra	THAP1	Q9NVV9	CSNK2A1	Homo sapiens	P68400	Y2H Prey Pooling	25416956
Intra	THAP1	Q9NVV9	CSNK2A1	Homo sapiens	P68400	Y2H Array	29892012
Intra	THAP1	Q9NVV9	NUP62	Homo sapiens	P37198	Y2H Bait-Prey Pool	25910212
Intra	THAP1	Q9NVV9	NUP62	Homo sapiens	P37198	MAPPIT	25416956
Intra	THAP1	Q9NVV9	NUP62	Homo sapiens	P37198	Y2H Array	25910212
Intra	THAP1	Q9NVV9	NUP62	Homo sapiens	P37198	Validated Y2H	25416956
Intra	THAP1	Q9NVV9	NUP62	Homo sapiens	P37198	Y2H Array	25416956
Intra	THAP1	Q9NVV9	NUP62	Homo sapiens	P37198	Y2H Array	32296183
Intra	THAP1	Q9NVV9	NUP62	Homo sapiens	P37198	Y2H Prey Pooling	25416956
Intra	THAP1	Q9NVV9	NUP62	Homo sapiens	P37198	Y2H Prey Pooling	32296183
Intra	THAP1	Q9NVV9	NUP62	Homo sapiens	P37198	Validated Y2H	25910212
Intra	THAP1	Q9NVV9	RPS25	Homo sapiens	P62851	Y2H Prey Pooling	25416956
Intra	THAP1	Q9NVV9	TPM3	Homo sapiens	P06753	Y2H Array	32296183
Intra	THAP1	Q9NVV9	TPM3	Homo sapiens	P06753	Y2H Prey Pooling	32296183
Intra	THAP1	Q9NVV9	BAG5	Homo sapiens	Q9UL15	Y2H Array	31515488
Intra	THAP1	Q9NVV9	BAG5	Homo sapiens	Q9UL15	Validated Y2H	25416956
Intra	THAP1	Q9NVV9	BAG5	Homo sapiens	Q9UL15	Validated Y2H	32296183
Intra	THAP1	Q9NVV9	BYSL	Homo sapiens	Q13895	Y2H Array	25416956
Intra	THAP1	Q9NVV9	BYSL	Homo sapiens	Q13895	Y2H Prey Pooling	25416956
Intra	THAP1	Q9NVV9	POLR2L	Homo sapiens	P62875	Validated Y2H	25416956
Intra	THAP1	Q9NVV9	POLR2L	Homo sapiens	P62875	Y2H Array	25416956
Intra	THAP1	Q9NVV9	POLR2L	Homo sapiens	P62875	Y2H Prey Pooling	25416956
Intra	THAP1	Q9NVV9	NKAPD1	Homo sapiens	Q6ZUT1	Y2H Array	25416956
Intra	THAP1	Q9NVV9	NKAPD1	Homo sapiens	Q6ZUT1	Y2H Prey Pooling	25416956
Intra	THAP1	Q9NVV9	RBM39	Homo sapiens	Q14498	Y2H Array	25416956
Intra	THAP1	Q9NVV9	PPIG	Homo sapiens	Q13427	Y2H Prey Pooling	25416956
Intra	THAP1	Q9NVV9	HCFC1	Homo sapiens	P51610	Anti Bait CoIP	28486698
Intra	THAP1	Q9NVV9	HCFC1	Homo sapiens	P51610	Y2H	28486698
Intra	THAP1	Q9NVV9	MORF4L1	Homo sapiens	Q9UBU8	Y2H Prey Pooling	25416956
Intra	THAP1	Q9NVV9	MORF4L1	Homo sapiens	Q9UBU8	Y2H Array	25416956
Intra	THAP1	Q9NVV9	MORF4L2	Homo sapiens	Q15014	Y2H Prey Pooling	25416956
Intra	THAP1	Q9NVV9	MORF4L2	Homo sapiens	Q15014	Y2H Array	25416956
Intra	THAP1	Q9NVV9	AP2B1	Homo sapiens	P63010	Validated Y2H	25416956
Intra	THAP1	Q9NVV9	PMP22	Homo sapiens	A0A6Q8PF08	Validated Y2H	32814053
Intra	THAP1	Q9NVV9	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Pooling	32814053
Intra	THAP1	Q9NVV9	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Array	32814053
Intra	THAP1	Q9NVV9	YES1	Homo sapiens	P07947	Validated Y2H	25416956
Intra	THAP1	Q9NVV9	YES1	Homo sapiens	P07947	Y2H Prey Pooling	32296183
Intra	THAP1	Q9NVV9	TRAF5	Homo sapiens	O00463	Y2H Prey Pooling	25416956
Intra	THAP1	Q9NVV9	TRAF5	Homo sapiens	O00463	Validated Y2H	25416956
Intra	THAP1	Q9NVV9	TRAF5	Homo sapiens	O00463	Y2H Array	25416956
Intra	THAP1	Q9NVV9	MRPL11	Homo sapiens	Q9Y3B7	Y2H Array	31515488
Intra	THAP1	Q9NVV9	MRPL11	Homo sapiens	Q9Y3B7	Validated Y2H	25416956
Intra	THAP1	Q9NVV9	MRPL11	Homo sapiens	Q9Y3B7	Y2H Array	25416956
Intra	THAP1	Q9NVV9	GPATCH2L	Homo sapiens	Q9NWQ4	Validated Y2H	25416956
Intra	THAP1	Q9NVV9	GPATCH2L	Homo sapiens	Q9NWQ4	Y2H Array	25416956
Intra	THAP1	Q9NVV9	GPATCH2L	Homo sapiens	Q9NWQ4	Y2H Prey Pooling	25416956
Intra	THAP1	Q9NVV9	ZCCHC10	Homo sapiens	Q8TBK6	Y2H Prey Pooling	25416956
Intra	THAP1	Q9NVV9	TCEA2	Homo sapiens	Q15560	Validated Y2H	25416956
Intra	THAP1	Q9NVV9	TCEA2	Homo sapiens	Q15560	Y2H Array	25416956
Intra	THAP1	Q9NVV9	TCEA2	Homo sapiens	Q15560	Y2H Prey Pooling	25416956
Intra	THAP1	Q9NVV9	NDUFV2	Homo sapiens	P19404	Y2H Array	32814053
Intra	THAP1	Q9NVV9	NDUFV2	Homo sapiens	P19404	Y2H Pooling	32814053
Intra	THAP1	Q9NVV9	NDUFV2	Homo sapiens	P19404	Validated Y2H	32814053
Intra	THAP1	Q9NVV9	STRBP	Homo sapiens	Q96SI9	Y2H Prey Pooling	25416956
Intra	THAP1	Q9NVV9	STRBP	Homo sapiens	Q96SI9	Validated Y2H	25416956
Intra	THAP1	Q9NVV9	STRBP	Homo sapiens	Q96SI9	Y2H Pooling	16189514
Intra	THAP1	Q9NVV9	NTAQ1	Homo sapiens	Q96HA8	Y2H	21516116
Intra	THAP1	Q9NVV9	NTAQ1	Homo sapiens	Q96HA8	Y2H Array	31515488
Intra	THAP1	Q9NVV9	NTAQ1	Homo sapiens	Q96HA8	Validated Y2H	25416956
Intra	THAP1	Q9NVV9	NTAQ1	Homo sapiens	Q96HA8	Y2H Array	25416956
Intra	THAP1	Q9NVV9	THAP1	Homo sapiens	Q9NVV9	Y2H	21516116
Intra	THAP1	Q9NVV9	THAP1	Homo sapiens	Q9NVV9	Validated Y2H	32296183
Intra	THAP1	Q9NVV9	THAP1	Homo sapiens	Q9NVV9	Y2H Array	25416956
Intra	THAP1	Q9NVV9	THAP1	Homo sapiens	Q9NVV9	Y2H Array	32296183
Intra	THAP1	Q9NVV9	THAP1	Homo sapiens	Q9NVV9	Y2H Prey Pooling	32296183
Intra	THAP1	Q9NVV9	THAP1	Homo sapiens	Q9NVV9	Validated Y2H	25910212
Intra	THAP1	Q9NVV9	THAP1	Homo sapiens	Q9NVV9	Y2H Pooling	16189514
Intra	THAP1	Q9NVV9	THAP1	Homo sapiens	Q9NVV9	Y2H Bait-Prey Pool	25910212
Intra	THAP1	Q9NVV9	THAP1	Homo sapiens	Q9NVV9	Y2H Array	25910212
Intra	THAP1	Q9NVV9	RALYL	Homo sapiens	Q86SE5	Validated Y2H	25416956
Intra	THAP1	Q9NVV9	RALYL	Homo sapiens	Q86SE5	Y2H Pooling	16189514
Intra	THAP1	Q9NVV9	U2AF2	Homo sapiens	P26368	Y2H Prey Pooling	25416956
Intra	THAP1	Q9NVV9	U2AF2	Homo sapiens	P26368	Validated Y2H	25416956
Intra	THAP1	Q9NVV9	MMTAG2	Homo sapiens	Q9BU76	Y2H Array	25416956
Intra	THAP1	Q9NVV9	MMTAG2	Homo sapiens	Q9BU76	Y2H Pooling	16189514
Intra	THAP1	Q9NVV9	LASP1	Homo sapiens	Q14847	Validated Y2H	25416956
Intra	THAP1	Q9NVV9	LASP1	Homo sapiens	Q14847	Y2H Prey Pooling	25416956
Intra	THAP1	Q9NVV9	GFAP	Homo sapiens	P14136	Validated Y2H	32814053
Intra	THAP1	Q9NVV9	GFAP	Homo sapiens	P14136	Y2H Array	32814053
Intra	THAP1	Q9NVV9	GFAP	Homo sapiens	P14136	Y2H Pooling	32814053
Intra	THAP1	Q9NVV9	FAM124A	Homo sapiens	Q86V42	Y2H Prey Pooling	25416956
Intra	THAP1	Q9NVV9	FAM124A	Homo sapiens	Q86V42	Y2H Array	25416956
Intra	THAP1	Q9NVV9	ZBTB48	Homo sapiens	P10074	Y2H Prey Pooling	32296183
Intra	THAP1	Q9NVV9	C1orf216	Homo sapiens	Q8TAB5	Y2H Array	32296183
Intra	THAP1	Q9NVV9	SLU7	Homo sapiens	O95391	Y2H Prey Pooling	25416956
Intra	THAP1	Q9NVV9	SLU7	Homo sapiens	O95391	Validated Y2H	25416956
Intra	THAP1	Q9NVV9	KLF12	Homo sapiens	Q9Y4X4	Y2H Array	25416956
Intra	THAP1	Q9NVV9	KLF12	Homo sapiens	Q9Y4X4	Validated Y2H	25416956
Intra	THAP1	Q9NVV9	C7orf50	Homo sapiens	Q9BRJ6	Validated Y2H	25416956
Intra	THAP1	Q9NVV9	SAP30BP	Homo sapiens	Q9UHR5	Y2H Array	25416956
Intra	THAP1	Q9NVV9	TTLL10	Homo sapiens	Q6ZVT0	Validated Y2H	25416956
Intra	THAP1	Q9NVV9	FAM9A	Homo sapiens	Q8IZU1	Y2H Prey Pooling	32296183
Intra	THAP1	Q9NVV9	FAM9A	Homo sapiens	Q8IZU1	Y2H Array	32296183
Intra	THAP1	Q9NVV9	ZNF385C	Homo sapiens	Q66K41	Y2H Prey Pooling	25416956
Intra	THAP1	Q9NVV9	ZNF385C	Homo sapiens	Q66K41	Y2H Array	25416956
Intra	THAP1	Q9NVV9	ZNF385C	Homo sapiens	Q66K41	Validated Y2H	25416956
Intra	THAP1	Q9NVV9	RAD54L2	Homo sapiens	Q9Y4B4	Y2H Array	32296183
Intra	THAP1	Q9NVV9	RAD54L2	Homo sapiens	Q9Y4B4	Y2H Prey Pooling	32296183
Intra	THAP1	Q9NVV9	RAD54L2	Homo sapiens	Q9Y4B4	Validated Y2H	32296183
Intra	THAP1	Q9NVV9	ACOT7	Homo sapiens	O00154	Validated Y2H	25416956
Intra	THAP1	Q9NVV9	RALY	Homo sapiens	Q53GL6	Y2H Array	32296183
Intra	THAP1	Q9NVV9	RALY	Homo sapiens	Q53GL6	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

THAP1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P84833	THAP1 Antibody (YA4530)	ICC/IF, FC, ELISA	Human
HY-P84833A	THAP1 Antibody (YA4530)(PBS only)	ICC/IF, FC, ELISA	Human

Related Diseases

Diseases	Alias
Dystonia 6, Torsion	DYT6 Torsion Dystonia 6 Dystonia 6 Idiopathic Torsion Dystonia Of Mixed Type Primary Dystonia, Dyt6 Type Torsion Dystonia, Adult-Onset, Mixed Type Dyt-Thap1 Adolescent-Onset Dystonia Of Mixed Type Torsion Dystonia Adult Onset Mixed Type Dyt6 Dystonia Thap1 Dystonia Generalized Cervical And Upper-Limb-Onset Dystonia Adult-Onset Torsion Dystonia Mixed Type Autosomal Dominant Torsion Dystonia 6 Dystonia-6 Torsion Dystonia Type 6 Dystonia, Type 6, Torsion
Dystonia	Dystonic Disease Dystonic Disorder Dystonia Disorders Neuroleptic Dyskinesia
Blepharospasm
Segmental Dystonia
Spasmodic Dystonia	Laryngeal Dystonia
Focal Hand Dystonia	Organic Writer'S Cramp Dystonia, Focal, Task-Specific
Multifocal Dystonia
Hemidystonia
Hereditary Lymphedema Ii	Meige Syndrome Meige Disease Meige Lymphedema Hereditary Lymphedema Type Ii Lymphedema Hereditary Type 2 Lymphedema Praecox Lymphedema, Hereditary, Ii Blepharospasm-Oromandibular Dystonia Syndrome Meige Dystonia Meige'S Syndrome Late-Onset Lymphedema Lmph2 Lymphedema Preacox Lymphedema, Late-Onset Blepharospasm - Oromandibular Dystonia Blepharospasm-Oromandibular Dystonia Brueghel Syndrome Idiopathic Blepharospasm-Oromandibular Dystonia Syndrome Oral Facial Dystonia Segmental Cranial Dystonia Meigs Syndrome
Cervical Dystonia	Spasmodic Torticollis
Dystonia 12	DYT12 Rdp Generalized Dystonia Dystonia-12 Rapid-Onset Dystonia-Parkinsonism Familial Dystonia Dystonia Musculorum Deformans Dystonic Disorders Idiopathic Familial Dystonia Dystonia-Parkinsonism, Rapid-Onset Fragments Of Torsion Dystonia Dyt-Atp1a3 Rapid-Onset Dystonia Parkinsonism Rodp Dystonia, Type 12 Dystonia 3, Torsion, X-Linked Idiopathic Non-Familial Dystonia Symptomatic Torsion Dystonia Dystonia Disorders
Oromandibular Dystonia
Dystonia 1, Torsion, Autosomal Dominant	Dystonia Musculorum Deformans 1 Dystonia Musculorum Deformans DYT1 Early-Onset Torsion Dystonia Eotd Dystonia-1, Torsion Torsion Dystonia 1 Autosomal Dominant Torsion Dystonia 1 Dystonia-1 Oppenheim'S Dystonia Oppenheim-Ziehen Disease Early Onset Torsion Dystonia Dystonia 3, Torsion, X-Linked
Dystonia 3, Torsion, X-Linked	X-Linked Dystonia-Parkinsonism DYT3 Xdp Lubag Dystonia-Parkinsonism, X-Linked Torsion Dystonia-Parkinsonism, Filipino Type Dyt-Taf1 X-Linked Dystonia-Parkinsonism Syndrome X-Linked Torsion Dystonia-Parkinsonism Syndrome Dystonia Musculorum Deformans X-Linked Dystonia-Parkinsonism/Lubag Lubag Syndrome Dystonia-3 Torsion Dystonia-Parkinsonism Filipino Type X-Linked Torsion Dystonia 3 Dystonia, Torsion, X-Linked, Type 3
Cranio-Facial Dystonia	Craniofacial Dystonia
Lymphatic Malformation 5	Meige Syndrome Meige Disease Meige Lymphedema Lymphedema Praecox Lymphedema, Late-Onset Late-Onset Lymphedema LMPH2 Meigs Syndrome LMPHM5 Lymphedema, Hereditary, Ii, Formerly Lmph2, Formerly Hereditary Lymphedema Ii Demons-Meigs Syndrome Hereditary Lymphedema Type Ii Lymphedema, Hereditary, 2 Lymphedema, Hereditary, Ii Meige'S Disease
Focal Dystonia	Dystonia, Focal, Task-Specific
Dystonia 24	DYT24 Cranio-Cervical Dystonia With Laryngeal And Upper-Limb Involvement Dystonia-24 Dystonia, Type 24
Dystonia 25	DYT25 Dystonia-25 Dystonia, Type 25
Torsion Dystonia 2	Dystonia 2, Torsion, Autosomal Recessive
Dystonia, Dopa-Responsive	Dystonia 5 Dopa-Responsive Dystonia DRD Dyt5 Dystonia-Parkinsonism With Diurnal Fluctuation Dyt-Th Hpd With Diurnal Fluctuation Hereditary Progressive Dystonia With Diurnal Fluctuation Dystonia, Progressive, With Diurnal Variation Segawa Syndrome, Autosomal Dominant Dystonia, Dopa-Responsive, Autosomal Dominant Dopa-Responsive Dystonia, Autosomal Dominant Dystonia, Dopa-Responsive, With Or Without Hyperphenylalaninemia Dyt-Gch1 Dyt-Spr Dystonia 5, Dopa-Responsive Type Hereditary Progressive Dystonia With Marked Diurnal Fluctuation Autosomal Dominant Dopa-Responsive Dystonia Autosomal Dominant Segawa Syndrome Dystonia-5 Progressive Dystonia With Diurnal Fluctuation Dystonia, Type 5, Dopa-Responsive Type
Dystonia 11, Myoclonic	Myoclonic Dystonia Myoclonus-Dystonia Syndrome DYT11 Myoclonic Dystonia 11 Alcohol-Responsive Dystonia Myoclonus, Hereditary Essential Dystonia-11, Myoclonic Myoclonus-Dystonia Dystonia 11 Hereditary Essential Myoclonus Dystonia, Alcohol-Responsive Dyt-Sgce Dystonia, Alcohol Responsive Dystonia-11 Dystonia, Myoclonic Dystonia, Myoclonic, Type 11
Ophthalmia Nodosa
Conversion Disorder	Conversion Hysteria Or Reaction Conversion Hysterical Neurosis Hysterical Neurosis, Conversion Type Fnd Functional Movement Disorder Functional Neurological Disorder Dissociative Disorder
Leber Optic Atrophy And Dystonia	LDYT Marsden Syndrome Leber Hereditary Optic Neuropathy With Dystonia Leber Hereditary Optic Neuropathy And Dystonia Familial Dystonia With Visual Failure And Striatal Lucencies Dystonia, Familial, With Visual Failure And Striatal Lucencies Leber Optic Atrophy With Dystonia Dystonia Familial, With Visual Failure And Striatal Lucencies Lhon And Dystonia Leber'S Hereditary Optic Neuropathy With Dystonia
Movement Disease	Movement Disorders Movement Disorder
Basal Ganglia Disease	Basal Ganglia Diseases Basal Ganglia Disorders Abnormality Of The Basal Ganglia
Neurodegeneration With Brain Iron Accumulation 1	Pantothenate Kinase-Associated Neurodegeneration Pkan NBIA1 Hallervorden-Spatz Disease Hallervorden-Spatz Syndrome Pigmentary Pallidal Degeneration Neuroaxonal Dystrophy, Late Infantile Neurodegeneration With Brain Iron Accumulation Type 1 Classic Pantothenate Kinase-Associated Neurodegeneration Pkan Neuroaxonal Dystrophy, Juvenile-Onset Brain Iron Accumulation Type I Syndrome Nbia Neurodegeneration With Brain Iron Accumulation Nbia1, Classic Form Neurodegeneration With Brain Iron Accumulation Type 1, Classic Form Pkan, Classic Form Atypical Pantothenate Kinase-Associated Neurodegeneration Nbia1, Atypical Form Neurodegeneration With Brain Iron Accumulation Type 1, Atypical Form Pkan, Atypical Form Hss Pkan Neuroaxonal Dystrophy Juvenile-Onset Neurodegeneration, With Brain Iron Accumulation, Type 1
Lesch-Nyhan Syndrome	Hypoxanthine-Guanine Phosphoribosyltransferase Deficiency LNS Hprt Deficiency Complete Hypoxanthine-Guanine Phosphoribosyltransferase Deficiency Hypoxanthine Guanine Phosphoribosyltransferase Deficiency X-Linked Hyperuricemia Choreoathetosis Self-Mutilation Syndrome Hprt1 Deficiency Hprt Deficiency, Complete Deficiency Of Imp Pyrophosphorylase Hgprt Deficiency Lesch-Nyhan Disease Hypoxanthine Guanine Phosphoribosyltransferase 1 Deficiency Hg-Prt Deficiency Hypoxanthine-Guanine-Phosphoribosyltransferase Deficiency Lesch - Nyhan Syndrome Hprt1 Disorders Lesch Nyhan Syndrome Complete Hprt Deficiency Complete Lesch Nyhan Disease Complete Hprt Deficiency Deficiency Of Guanine Phosphoribosyltransferase Deficiency Of Hypoxanthine Phosphoribosyltransferase Hypoxanthine Phosphoribosyltransferase Deficiency Juvenile Gout, Choreoathetosis, Mental Retardation Syndrome Juvenile Hyperuricemia Syndrome Lnd Primary Hyperuricemia Syndrome Total Hprt Deficiency Total Hypoxanthine-Guanine Phosphoribosyl Transferase Deficiency X-Linked Primary Hyperuricemia X-Linked Uric Aciduria Enzyme Defect Hprt Complete Deficiency Hprt Deficiency Grade Iv Hypoxanthine Guanine Phosphoribosyltransferase Complete Deficiency Hypoxanthine Guanine Phosphoribosyltransferase Deficiency, Grade Iv Hypoxanthine-Guanine Phosphoribosyltransferase 1 Deficiency Hprt - [ Hypoxanthine-Guanine Phosphoribosyltransferase] Complete Deficiency Total Hgprt - [Hypoxanthine-Guanine Phosphoribosyltransferase] Deficiency
Alternating Hemiplegia Of Childhood	Alternating Hemiplegia Ahc Alternating Hemiplegia Syndrome Hemiplegia, Alternating, Of Childhood Hemiplegia, Crossed
Basal Ganglia Calcification	Fahr'S Syndrome Fahr'S Disease Fahr Disease
Choreatic Disease	Chorea Hereditary Chorea
Neurodegeneration With Brain Iron Accumulation	Nbia Neurodegeneration With Brain Iron Accumulation Disorders Neurodegeneration, With Brain Iron Accumulation
Leber Plus Disease	Leber Congenital Amaurosis Lca Leber'S Amaurosis Leber'S Disease Amaurosis Congenita Of Leber Amaurosis Congenita Of Leber, Type 1 Lhon Plus Disease Congenital Absence Of The Rods And Cones Congenital Retinal Blindness Crb Congenital Amaurosis Of Retinal Origin Leber'S Congenital Amaurosis Leber Congenital Amaurosis 1 Leber'S Congenital Tapetoretinal Degeneration Leber'S Congenital Tapetoretinal Dysplasia Lca1 Leber Congenital Amaurosis Type 1 Retinal Blindness, Congenital Amaurosis, Leber Congenital Dysgenesis Neuroepithelialis Retinae Hereditary Epithelial Dysplasia Of Retina Hereditary Retinal Aplasia Heredoretinopathia Congenitalis Leber Abiotrophy Leber Congenital Tapetoretinal Degeneration Lebers Congenital Amaurosis Optic Atrophy, Hereditary, Leber

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14469	THAP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	THAP1	VGNC	VGNC:104499
Canis familiaris	THAP1	VGNC	VGNC:47324
Mus musculus	THAP1	MGD	MGI:1921004
Bos taurus	THAP1	VGNC	VGNC:35818
Rattus norvegicus	THAP1	RGD	RGD:1307589
Others	THAP1	NCBI