GAPDHS - glyceraldehyde-3-phosphate dehydrogenase, spermatogenic Gene

Also Known as GAPD2; GAPDS; HSD-35; GAPDH-2; HEL-S-278

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 26330

About GAPDHS

Cytogenetic location: 19q13.12 Genomic coordinates (GRCh38): 19:35,533,456-35,545,319 (from NCBI)

This gene has 3 transcripts (splice variants), 189 orthologues and 1 paralogue. Biased expression in testis (RPKM 87.7) and thyroid (RPKM 2.9).

Summary

This gene encodes a protein belonging to the glyceraldehyde-3-phosphate dehydrogenase family of Enzymes that play an important role in carbohydrate metabolism. Like its somatic cell counterpart, this sperm-specific enzyme functions in a nicotinamide adenine dinucleotide-dependent manner to remove hydrogen and add phosphate to glyceraldehyde 3-phosphate to form 1,3-diphosphoglycerate. During spermiogenesis, this enzyme may play an important role in regulating the switch between different energy-producing pathways, and it is required for sperm motility and male fertility. [provided by RefSeq, Jul 2008]

GAPDHS Products (1)

mRNA Protein Name
NM_014364.5 NP_055179.1 glyceraldehyde-3-phosphate dehydrogenase, testis-specific

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16820410 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GAPDHS Protein Structure

Gp_dh_N

Gp_dh_N: Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain (77 - 224)

Gp_dh_C

Gp_dh_C: Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain (229 - 386)

  • 0
  • 100
  • 200
  • 300
  • 408 a.a.
Protein Preferred Names Protein Names

glyceraldehyde-3-phosphate dehydrogenase, testis-specific

  • epididymis secretory protein Li 278

GAPDHS Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GAPDHS O14556 ZMYND19 Homo sapiens Q96E35
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Ovarian Dysgenesis 2

  • Premature Ovarian Failure 4

  • ODG2

  • Ovarian Dysgenesis, Hypergonadotropic, X-Linked

  • Ovarian Failure, Hypergonadotropic, Due To Ovarian Dysgenesis

  • Ovarian Failure Hypergonadotropic Due To Ovarian Dysgenesis

  • X-Linked Hypergonadotropic Ovarian Dysgenesis

  • POF4

  • Dysgenesis, Ovarian, Type 2
Retinitis Pigmentosa 38

  • RP38

  • Rod-Cone Dystrophy, Childhood-Onset

  • Retinitis Pigmentosa, Type 38
Corneal Dystrophy And Perceptive Deafness

  • Corneal Dystrophy-Perceptive Deafness Syndrome

  • CDPD

  • Harboyan Syndrome

  • Cdpd1

  • Corneal Dystrophy And Sensorineural Deafness

  • Corneal Endothelial Dystrophy And Perceptive Deafness

  • Corneal Dystrophy With Progressive Deafness

  • Congenital Corneal Dystrophy, Progressive Sensorineural Deafness

  • Corneal Dystrophy With Progressive Hearing Loss

  • Corneal Dystrophy-Perceptive Hearing Loss Syndrome

  • Dystrophy, Corneal, Endothelial, And Perceptive Deafness
Spermatogenic Failure

  • Azoospermia

  • Spgf

  • Spermatogenic Failure, Susceptibility To

  • Absent Sperm

  • Aspermatogenesis

  • Infertility Due To Azoospermia

  • Hypospermatogenesis

  • Azoospermatism
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B1087 Prednisolone hemisuccinate 99.89% Unkown

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-16361A Omigapil maleate Inhibitor 99.84% Phase 2
HY-16361 Omigapil Inducer / Phase 2
HY-147280 Misetionamide Inducer 99.49% Phase 1

Pre-clinical Phase

Bioactive Molecules (101)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-D0849 Sodium iodoacetate Inhibitor 99.91% Unkown
HY-123962 G6PD activator AG1 99.54% Unkown
HY-112758 DLin-KC2-DMA 99.88% Unkown
HY-120838 Heptelidic acid Inhibitor 97.5% Unkown
HY-157395 malonyl-NAC Inhibitor 98.74% Unkown
HY-156823 GAPDH Positive Control siRNA (Human) Pre-designed Set 98.72% Unkown
HY-43643 DC-5163 Inducer 99.30% Unkown
HY-N15156 Thiotaurine 99.27% Unkown
HY-156824 GAPDH siRNA Positive Control (Mouse/Rat) Pre-designed Set 98.09% Unkown
HY-171036 GAPDH-IN-1 Inhibitor 98.10% Unkown
HY-RS29497 GAL3ST2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-132126 SPHINX Inhibitor 99.87% Unkown
HY-RS29457 TMEM175 Monkey Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00759 ANXA11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00845 APOC2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05274 GAPDHS Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-128788A ddhCTP trisodium solution (100 mM) Inhibitor / Unkown
HY-RS00844 APOC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16258 Lipt1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16283 FAM-labeled P3H3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29445 Ndufaf6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29463 GCNT4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29469 GPR146 Domestic cattle Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29474 Dpm3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29475 CEPT1 Human/Cat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29476 Akap1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29477 Mmachc Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29478 Vps13b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29483 GM2A Cattle Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29484 Tnxb Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29490 Zpbp Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29491 Taco1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29492 Itpr1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29496 Prkaa1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29498 LOC771 Monkey Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29499 SP1 Monkey Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29507 Hnrnpdl Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29509 Rab7a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29510 Ociad2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29512 AP1AR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29515 Slc30a8 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29516 BLOC1S3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29518 Rab7 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29519 C1ra Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-119062 A-800141 Inhibitor / Unkown
HY-123668 KM05382 Inhibitor / Unkown
HY-128788 ddhCTP Inhibitor / Unkown
HY-131921 DL-Glyceraldehyde 3-phosphate diethyl acetal barium / Unkown
HY-161668 Ru-Poma / Unkown
HY-184150 EN10 Ligand / Unkown
HY-186183 Normethyl-ZCAN262 Modulator / Unkown
HY-N3247 Monomethyl kolavate Inhibitor / Unkown
HY-RS01637 BRSK1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01840 CALM1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01842 CALM3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS02352 CDK11A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03616 DDIT4L Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04221 EHD1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05787 GRHL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05789 GRHL3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06491 HUNK Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10438 PHKA2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15382 UBP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29504 Acot4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-170714 siRNA positive control (Rat GAPDH) (2-OMe) Pre-designed Set / Unkown
HY-RS16268 Islr Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16274 Human CDC27P10 Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16289 St6galnac4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16311 Herc6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17563 Anxa10 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18382 Cdk10 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19408 Apoa4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19983 Apoa2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22883 Trrap Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23297 Hipk2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23792 Brsk2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24288 Trio Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24540 Fosl2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24560 Anxa13 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24635 Anxa6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25291 Anxa4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25348 Cnksr3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25659 Anxa8 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26152 Calm2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26883 Cdk15 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27368 Anxa9 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27463 Grhl2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29448 ILF2 Pig Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29449 ANKRD31 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29456 Ncr3lg1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29458 Tmem19 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29459 Tmem19 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29468 Spaca1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29486 SLC25A15 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29489 Eqtn Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29493 Efr3b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29495 Glis3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29505 Dnajc15 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29506 ZNF22 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29508 Myo19 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29511 Serpina1a Mouse Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus GAPDHS VGNC VGNC:29248
Macaca mulatta GAPDHS VGNC VGNC:72778
Mus musculus GAPDHS MGD MGI:95653
Rattus norvegicus GAPDHS RGD RGD:620150
Felis catus GAPDHS VGNC VGNC:62460
Canis familiaris GAPDHS VGNC VGNC:41109
Others GAPDHS NCBI