Ru-Poma
Ru-Poma is a Ru(II)-based photosensitizer, which attenuates Cisplatin (HY-17394)-resistant tumor through photodynamic therapy (PDT). Ru-Poma photodegrades CRBN through a Pomalidomide (HY-10984) moiety. Ru-Poma induces ferroptosis, through an increase in lipid peroxide, downregulation of GPX4 and GAPDH expression. Ru-Poma exhibits cytotoxicity in A549, with IC50 of 18.46 μM and 0.37 μM in dark and upon irradiation, respectively.
For research use only. We do not sell to patients.
- Formula: C89H75Cl2N11O11Ru.7H2O
- Molecular Weight:1664.61
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cereblon |
Chemical Information
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Molecular Weight 1664.61
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Formula C89H75Cl2N11O11Ru.7H2O
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SMILES
O=C1N(C(C2=C1C(NCCCOC3=CC=C(C4=NC5=C(C6=CC=C[N]7=C6C8=C5C=CC=[N]8[Ru+2]79([N]%10=CC=C(C(C=C%11)=C%10%12)C%13=CC=CC=C%13)([N]%14=CC=C(C%15=C%14C%16=[N]9C=CC(C%17=CC=CC=C%17)=C%16C=C%15)C%18=CC=CC=C%18)[N]%19=C%12C%11=C(C=C%19)C%20=CC=CC=C%20)N4C%21=CC=CC=C%21)C=C3)=CC=C2)=O)C%22CCC(NC%22=O)=O.O.O.O.O.O.O.[Cl-].[Cl-].O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (271 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Ru-Poma Related Classifications
HY-161668 Related Classifications
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