2. Apoptosis
  3. Apoptosis
  4. Omigapil

Omigapil (CGP3466B free base), an orally active GAPDH nitrosylation inhibitor, abrogates Aβ1-42-induced tau acetylation, memory impairment, and locomotor dysfunction in mice. Omigapil has the potential for the research of Alzheimer's disease. Omigapil is a apoptosis inhibitor. Omigapil can be used for the research of congenital muscular dystrophy (CMD). Omigapil is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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CAS No. : 181296-84-4

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Description

Omigapil (CGP3466B free base), an orally active GAPDH nitrosylation inhibitor, abrogates Aβ1-42-induced tau acetylation, memory impairment, and locomotor dysfunction in mice. Omigapil has the potential for the research of Alzheimer's disease. Omigapil is a apoptosis inhibitor. Omigapil can be used for the research of congenital muscular dystrophy (CMD). Omigapil is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups[1][2].

Clinical Trial
Molecular Weight

275.34

Formula

C19H17NO
CAS No.
SMILES

C#CCN(CC1=CC2=C(OC3=C1C=CC=C3)C=CC=C2)C
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In Vivo:

The following protocol is derived from the literature and is for reference only. It is recommended to first try a small sample.

  • Protocol 1

    Omigapil (CGP3466B) is dissolved in phosphate-buffered saline (PBS, 0.1 mol/L, pH 7.4)[1].

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Omigapil181296-84-4CGP3466B TCH346TCH346TCH 346TCH-346Apoptosisanti-apoptosiscongenitalmusculardystrophyCMDGAPDHnitrosylationAβtauacetylationmemoryimpairmentlocomotordysfunctionAlzheimerdiseaseInhibitorinhibitorinhibit

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