Sodium iodoacetate
Based on 2 publication(s) in Google Scholar
Sodium iodoacetate is a specific inhibitor of GAPDH and has glycolysis inhibitory activity. In addition, sodium iodoacetate can induce osteoarthritis and related pain models in experimental animals.
For research use only. We do not sell to patients.
- Purity: 99.91%
- CAS No.: 305-53-3
- Formula: C2H2INaO2
- Molecular Weight:207.93
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Sodium iodoacetate
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Biological Activity
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 305-53-3
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Appearance Solid
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Molecular Weight 207.93
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Formula C2H2INaO2
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Color White to off-white
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SMILES
O=C(O[Na])CI
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Synonyms
Iodoacetic acid sodium salt
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (2)
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Journal Impact Factor
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Most Recent
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J Drug Target
Platelet-rich plasma ameliorates knee osteoarthritis in rats by modulating the abundance of gut Lactobacillus murinus. [Abstract]2026 Mar 27:1-10. PMID: 41860290 -
Sci Rep
Cycloastragenol attenuates osteoarthritis by restoring chondrocyte senescence via the NRF2/NF-κB signaling axis. [Abstract]2026 Mar 12;16(1):13203. PMID: 41813816
Solvent & Solubility
DMSO : 100 mg/mL (480.93 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : ≥ 100 mg/mL (480.93 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: Saline
Solubility: ≥ 100 mg/mL (480.93 mM); Clear solution
Purity & Documentation
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Data Sheet (272 KB)
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SDS (642 KB)
- English - EN (642 KB)
- Français - FR (642 KB)
- Deutsch - DE (642 KB)
- Norwegian - NO (642 KB)
- Español - ES (642 KB)
- Swedish - SV (642 KB)
- Italian - IT (642 KB)
- Korean - KR (642 KB)
- Portuguese - PT (642 KB)
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Handling Instructions (2659 KB)
References
[1]. Xu, Y. et al. Glycolysis in Innate Immune Cells Contributes to Autoimmunity. Frontiers in Immunology, 13. [Content Brief]
[2]. Na, H. et al. Soluble CCR2 gene therapy controls joint inflammation, cartilage damage, and the progression of osteoarthritis by targeting MCP-1 in a monosodium iodoacetate (MIA)-induced OA rat model. Journal of Translational Medicine, 20(1) [Content Brief]
[3]. Kobayashi K, et al. Sodium iodoacetate-induced experimental osteoarthritis and associated pain model in rats[J]. Journal of Veterinary Medical Science, 2003, 65(11): 1195-1199. [Content Brief]
[4]. Güler N, et al. Sodium iodoacetate induced osteoarthrosis model in rabbit temporomandibular joint: CT and histological study (part I)[J]. International journal of oral and maxillofacial surgery, 2011, 40(11): 1289-1295. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 4.8093 mL | 24.0466 mL | 48.0931 mL | 120.2328 mL |
| 5 mM | 0.9619 mL | 4.8093 mL | 9.6186 mL | 24.0466 mL | |
| 10 mM | 0.4809 mL | 2.4047 mL | 4.8093 mL | 12.0233 mL | |
| 15 mM | 0.3206 mL | 1.6031 mL | 3.2062 mL | 8.0155 mL | |
| 20 mM | 0.2405 mL | 1.2023 mL | 2.4047 mL | 6.0116 mL | |
| 25 mM | 0.1924 mL | 0.9619 mL | 1.9237 mL | 4.8093 mL | |
| 30 mM | 0.1603 mL | 0.8016 mL | 1.6031 mL | 4.0078 mL | |
| 40 mM | 0.1202 mL | 0.6012 mL | 1.2023 mL | 3.0058 mL | |
| 50 mM | 0.0962 mL | 0.4809 mL | 0.9619 mL | 2.4047 mL | |
| 60 mM | 0.0802 mL | 0.4008 mL | 0.8016 mL | 2.0039 mL | |
| 80 mM | 0.0601 mL | 0.3006 mL | 0.6012 mL | 1.5029 mL | |
| 100 mM | 0.0481 mL | 0.2405 mL | 0.4809 mL | 1.2023 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Sodium iodoacetate Related Classifications
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