Sodium iodoacetate
Based on 2 publication(s) in Google Scholar
Sodium iodoacetate is a specific inhibitor of GAPDH and has glycolysis inhibitory activity. In addition, sodium iodoacetate can induce osteoarthritis and related pain models in experimental animals.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.95%
- CAS 番号: 305-53-3
- 分子式: C2H2INaO2
- 分子量:207.93
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保管条件:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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MedChemExpress（MCE）の使用を引用している文献 Sodium iodoacetate
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生物活性
製品説明
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 305-53-3
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性状 Solid
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分子量 207.93
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分子式 C2H2INaO2
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Color White to off-white
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SMILES
O=C(O[Na])CI
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別名
Iodoacetic acid sodium salt
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (2)
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Journal Impact Factor
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Most Recent
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Sci Rep
Cycloastragenol attenuates osteoarthritis by restoring chondrocyte senescence via the NRF2/NF-κB signaling axis. [Abstract]2026 Mar 12;16(1):13203. PMID: 41813816 -
J Drug Target
Platelet-rich plasma ameliorates knee osteoarthritis in rats by modulating the abundance of gut Lactobacillus murinus. [Abstract]2026 Mar 27:1-10. PMID: 41860290
溶剤 & 溶解度
体外:
DMSO : 100 mg/mL (480.93 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : ≥ 100 mg/mL (480.93 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
体内:
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: Saline
Solubility: ≥ 100 mg/mL (480.93 mM); Clear solution
純度とドキュメンテーション
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データシート (272 KB)
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SDS (642 KB)
- English - EN (642 KB)
- Français - FR (642 KB)
- Deutsch - DE (642 KB)
- Norwegian - NO (642 KB)
- Español - ES (642 KB)
- Swedish - SV (642 KB)
- Italian - IT (642 KB)
- Korean - KR (642 KB)
- Portuguese - PT (642 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Xu, Y. et al. Glycolysis in Innate Immune Cells Contributes to Autoimmunity. Frontiers in Immunology, 13. [Content Brief]
[2]. Na, H. et al. Soluble CCR2 gene therapy controls joint inflammation, cartilage damage, and the progression of osteoarthritis by targeting MCP-1 in a monosodium iodoacetate (MIA)-induced OA rat model. Journal of Translational Medicine, 20(1) [Content Brief]
[3]. Kobayashi K, et al. Sodium iodoacetate-induced experimental osteoarthritis and associated pain model in rats[J]. Journal of Veterinary Medical Science, 2003, 65(11): 1195-1199. [Content Brief]
[4]. Güler N, et al. Sodium iodoacetate induced osteoarthrosis model in rabbit temporomandibular joint: CT and histological study (part I)[J]. International journal of oral and maxillofacial surgery, 2011, 40(11): 1289-1295. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 4.8093 mL | 24.0466 mL | 48.0931 mL | 120.2328 mL |
| 5 mM | 0.9619 mL | 4.8093 mL | 9.6186 mL | 24.0466 mL | |
| 10 mM | 0.4809 mL | 2.4047 mL | 4.8093 mL | 12.0233 mL | |
| 15 mM | 0.3206 mL | 1.6031 mL | 3.2062 mL | 8.0155 mL | |
| 20 mM | 0.2405 mL | 1.2023 mL | 2.4047 mL | 6.0116 mL | |
| 25 mM | 0.1924 mL | 0.9619 mL | 1.9237 mL | 4.8093 mL | |
| 30 mM | 0.1603 mL | 0.8016 mL | 1.6031 mL | 4.0078 mL | |
| 40 mM | 0.1202 mL | 0.6012 mL | 1.2023 mL | 3.0058 mL | |
| 50 mM | 0.0962 mL | 0.4809 mL | 0.9619 mL | 2.4047 mL | |
| 60 mM | 0.0802 mL | 0.4008 mL | 0.8016 mL | 2.0039 mL | |
| 80 mM | 0.0601 mL | 0.3006 mL | 0.6012 mL | 1.5029 mL | |
| 100 mM | 0.0481 mL | 0.2405 mL | 0.4809 mL | 1.2023 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Sodium iodoacetate 関連分類
HY-D0849 関連分類
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