RAD54L2 - RAD54 like 2 Gene

Also Known as ARIP4; HSPC325; SRISNF2L

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23132

About RAD54L2

Cytogenetic location: 3p21.2 Genomic coordinates (GRCh38): 3:51,538,719-51,668,660 (from NCBI)

This gene has 7 transcripts (splice variants), 260 orthologues and 30 paralogues. Ubiquitous expression in testis (RPKM 3.3), spleen (RPKM 2.8) and 25 other tissues.

Summary

Predicted to enable ATP hydrolysis activity; protein kinase binding activity; and transcription coregulator activity. Predicted to be involved in DNA duplex unwinding. Predicted to act upstream of or within positive regulation of transcription by RNA polymerase II. Predicted to be located in nuclear speck. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

RAD54L2 Products (6)

mRNA Protein Name
NM_001322253.2 NP_001309182.1 helicase ARIP4 isoform a
NM_001322256.2 NP_001309185.1 helicase ARIP4 isoform a
NM_001387866.1 NP_001374795.1 helicase ARIP4 isoform c
NM_001387867.1 NP_001374796.1 helicase ARIP4 isoform d
NM_001387869.1 NP_001374798.1 helicase ARIP4 isoform e
NM_015106.4 NP_055921.2 helicase ARIP4 isoform a

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAD54L2 Protein Structure

SNF2_N

SNF2_N: SNF2 family N-terminal domain (274 - 597)

Helicase_C

Helicase_C: Helicase conserved C-terminal domain (778 - 854)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1467 a.a.
Protein Preferred Names Protein Names

helicase ARIP4

  • AR interacting protein 4

RAD54L2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RAD54L2 Q9Y4B4 PSMA3 Homo sapiens P25788
Y2H Array
25416956
Intra
RAD54L2 Q9Y4B4 PSMA3 Homo sapiens P25788
Y2H Prey Pooling
25416956
Intra
RAD54L2 Q9Y4B4 SIAH1 Homo sapiens Q8IUQ4
Y2H Prey Pooling
25416956
Intra
RAD54L2 Q9Y4B4 SUMO1 Homo sapiens P63165
Validated Y2H
25416956
Intra
RAD54L2 Q9Y4B4 SUMO1 Homo sapiens P63165
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Intellectual Developmental Disorder, Autosomal Dominant 7

  • MRD7

  • Mental Retardation, Autosomal Dominant 7

  • Autosomal Dominant Non-Syndromic Intellectual Disability 7

  • Dyrk1a Syndrome

  • Autosomal Dominant Intellectual Developmental Disorder 7

  • Autosomal Dominant Mental Retardation 7

  • Mental Retardation, Autosomal Dominant, Type 7
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11613 RAD54L2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus RAD54L2 VGNC VGNC:49152
Canis familiaris RAD54L2 VGNC VGNC:49612
Macaca mulatta RAD54L2 VGNC VGNC:108150
Mus musculus RAD54L2 MGD MGI:1933196
Felis catus RAD54L2 VGNC VGNC:64479
Rattus norvegicus RAD54L2 RGD RGD:1561889
Others RAD54L2 NCBI